Evidence map›Paper›PMID 34616495›Full record

ReviewTherapeutic advances in musculoskeletal disease2021

Diagnosis and management of lung involvement in systemic lupus erythematosus and Sjögren's syndrome: a literature review.

Roberto Depascale, Giulia Del Frate, Michela Gasparotto, Valeria Manfrè, Mariele Gatto, Luca Iaccarino, Luca Quartuccio, Salvatore De Vita, Andrea Doria

Open access · goldAbstract readReview
In one paragraph

Review in Therapeutic advances in musculoskeletal disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 33 citations in OpenAlex.

  1. Review
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  13. Hypoxia and a Concerning Chest Radiograph After 40 Years of Lupus.Journal of the American College of Emergency Physicians open · 2025
    Review
  14. Article
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  18. Review
  19. Article
  20. Thoracic manifestations of rheumatic disease: a radiologist's view.Therapeutic advances in musculoskeletal disease · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Roberto DepascaleRheumatology Unit, Department of Medicine, University of Padua, Padua, Italy.
Giulia Del FrateRheumatology Unit, Department of Medicine, University of Udine, Udine, Italy.
Michela GasparottoRheumatology Unit, Department of Medicine, University of Padua, Padua, Italy.
Valeria ManfrèRheumatology Unit, Department of Medicine, University of Udine, Udine, Italy.
Mariele GattoRheumatology Unit, Department of Medicine, University of Padua, Padua, Italy.
Luca IaccarinoRheumatology Unit, Department of Medicine, University of Padua, Padua, Italy.
Luca QuartuccioRheumatology Unit, Department of Medicine, University of Udine, Udine, Italy.
Salvatore De VitaRheumatology Unit, Department of Medicine, University of Udine, Udine, Italy.
Andrea DoriaDivision of Rheumatology, Department of Medicine, University of Padua, Via Giustiniani, 2, 35128 Padua, Italy.ORCID https://orcid.org/0000-0003-0548-4983
University of Padua · ITUniversity of Udine · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lung involvement in systemic lupus erythematosus (SLE) and primary Sjögren's syndrome (pSS) has extensively been outlined with a multiplicity of different manifestations. In SLE, the most frequent finding is pleural effusion, while in pSS, airway disease and parenchymal disorders prevail. In both cases, there is an increased risk of pre-capillary and post-capillary pulmonary arterial hypertension (PAH) and pulmonary venous thromboembolism (VTE). The risk of VTE is in part due to an increased thrombophilic status secondary to systemic inflammation or to the well-established association with antiphospholipid antibody syndrome (APS). The lung can also be the site of an organ-specific complication due to the aberrant pathologic immune-hyperactivation as occurs in the development of lymphoma or amyloidosis in pSS. Respiratory infections are a major issue to be addressed when approaching the differential diagnosis, and their exclusion is required to safely start an immunosuppressive therapy. Treatment strategy is mainly based on glucocorticoids (GCs) and immunosuppressants, with a variable response according to the primary pathologic process. Anticoagulation is recommended in case of VTE and multi-targeted treatment regimens including different drugs are the mainstay for PAH management. Antibiotics and respiratory physiotherapy can be considered relevant complement therapeutic measures. In this article, we reviewed lung manifestations in SLE and pSS with the aim to provide a comprehensive overview of their diagnosis and management to physicians taking care of patients with connective tissue diseases.

Indexed as

primary Sjogren’s syndromepulmonary involvementsystemic inflammationsystemic lupus erythematosustherapeutic strategies

Identifiers

PMID34616495
PMCPMC8488521
OpenAlexW3204625736

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.