Evidence map›Paper›PMID 34616405›Full record

ReviewFrontiers in immunology2021

Approaches to Establishing Tolerance in Immune Mediated Diseases.

Michelle F Huffaker, Srinath Sanda, Sindhu Chandran, Sharon A Chung, E William St Clair, Gerald T Nepom, Dawn E Smilek

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Review
  3. Remote loading of an autoantigen in PLGA nanoparticles for the treatment of multiple sclerosis.Journal of controlled release : official journal of the Controlled Release Society · 2025
    Article
  4. Receptor-Mediated SPION Labeling of CD4Nanomaterials (Basel, Switzerland) · 2025
    Article
  5. Review
  6. Article
  7. Induction of immune tolerance in NMOSD and MOGAD.Therapeutic advances in neurological disorders · 2025
    Review
  8. Review
  9. Article
  10. Article
  11. Breakdown and Repair of Peripheral Immune Tolerance in Type 1 Diabetes.Cold Spring Harbor perspectives in medicine · 2024
    Review
  12. Review
  13. Review
  14. Role of Citrullinated Collagen in Autoimmune Arthritis.International journal of molecular sciences · 2022
    Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Michelle F HuffakerImmune Tolerance Network, University of California San Francisco, San Francisco, CA, United States.
Srinath SandaImmune Tolerance Network, University of California San Francisco, San Francisco, CA, United States.
Sindhu ChandranImmune Tolerance Network, University of California San Francisco, San Francisco, CA, United States.
Sharon A ChungImmune Tolerance Network, University of California San Francisco, San Francisco, CA, United States.
E William St ClairImmune Tolerance Network, Duke University, Durham, NC, United States.
Gerald T NepomImmune Tolerance Network, Benaroya Research Institute, Seattle, WA, United States.
Dawn E SmilekImmune Tolerance Network, University of California San Francisco, San Francisco, CA, United States.
University of California, San Francisco · USImmune Tolerance Network · USBenaroya Research InstituteDuke University · US

Funding

Immune Tolerance Network UM1 2023 SupplementUM1AI109565 · NIAID · BENAROYA RESEARCH INST AT VIRGINIA MASON · PI Mark S Anderson, Jane Hoyt Buckner · 2014 to 2026
$451.6M
NIAID NIH HHS UM1 AI109565
6 · The paper itself

Abstract

The development of rational approaches to restore immune tolerance requires an iterative approach that builds on past success and utilizes new mechanistic insights into immune-mediated pathologies. This article will review concepts that have evolved from the clinical trial experience of the Immune Tolerance Network, with an emphasis on lessons learned from the innovative mechanistic studies conducted for these trials and new strategies under development for induction of tolerance.

Indexed as

HumansImmune System DiseasesImmune Toleranceallergyautoimmunityclinical trialimmune toleranceimmunomodulationimmunosuppressiontransplantation

Identifiers

PMID34616405
PMCPMC8488342
OpenAlexW3200227807

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.