Evidence map›Paper›PMID 34616075›Full record

ArticleNature2021

A multimodal cell census and atlas of the mammalian primary motor cortex.

BRAIN Initiative Cell Census Network (BICCN)

Abstract readComparative Study
In one paragraph

Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 326 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
326citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

326 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  6. Distinct single-nucleus RNA-seq changes among non-neuronal cells in ADNC, LATE-NC, and mixed pathologies.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
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266 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author.

BRAIN Initiative Cell Census Network (BICCN)

Funding

Washington National Primate Research CenterP51OD010425 · OD · UNIVERSITY OF WASHINGTON · PI Mari Ostendorf · 2012 to 2026
$201.8M
Viral Vector Core (VVC)P30CA014195 · NCI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI Reuben Shaw · 1985 to 2026
$82.8M
Generation of novel cell type specific mouse genetic toolsU19MH114830 · NIMH · ALLEN INSTITUTE · PI ANDERSON, DAVID J, PACHTER, LIOR S · 2017 to 2021
$64.7M
Tool and Technology Development CoreU19MH114821 · NIMH · COLD SPRING HARBOR LABORATORY · PI ARLOTTA, PAOLA, HUANG, Z JOSH · 2017 to 2021
$64.5M
Institute of Translational Health SciencesUL1TR000423 · NCATS · UNIVERSITY OF WASHINGTON · PI DISIS, MARY L. · 2012 to 2016
$49.4M
University of Washington Alzheimer's Disease Research CenterP30AG066509 · NIA · UNIVERSITY OF WASHINGTON · PI Thomas J. Grabowski · 2020 to 2026
$29.0M
Molecular SignaturesU19MH114831 · NIMH · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI CALLAWAY, EDWARD M · 2017 to 2021
$24.6M
A multimodal atlas of human brain cell typesU01MH114812 · NIMH · ALLEN INSTITUTE · PI LEIN, ED · 2017 to 2021
$19.2M
A BRAIN Initiative Resource: The Neuroscience Multi-omic Data ArchiveR24MH114788 · NIMH · UNIVERSITY OF MARYLAND BALTIMORE · PI Anup Mahurkar, Owen R White · 2017 to 2026
$17.2M
A Community Resource for Single Cell Data in the BrainU24MH114827 · NIMH · ALLEN INSTITUTE · PI HAWRYLYCZ, MICHAEL, MARTONE, MARYANN E · 2017 to 2021
$14.4M
Anatomical characterization of neuronal cell types of the mouse brainU01MH114829 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ASCOLI, GIORGIO A, DONG, HONG-WEI · 2017 to 2021
$13.9M
Cell atlas of mouse brain-spinal cord connectomeU01MH116990 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI DONG, HONG-WEI, TAO, HUIZHONG WHIT · 2018 to 2022
$12.0M
Howard Hughes Medical InstituteNCATS NIH HHS UL1 TR000423NCI NIH HHS P30 CA014195NEI NIH HHS R01 EY023173NIA NIH HHS P30 AG066509NIA NIH HHS R24 AG073205NIDCD NIH HHS R01 DC019370NIH HHS OD010425NIH HHS P51 OD010425NIH HHS S10 OD023689NIMH NIH HHS R01 MH094360NIMH NIH HHS R01 MH120404NIMH NIH HHS R01 MH122169NIMH NIH HHS R24 MH114788NIMH NIH HHS R24 MH114793NIMH NIH HHS R24 MH114815NIMH NIH HHS R24 MH117295NIMH NIH HHS RF1 MH114126NIMH NIH HHS RF1 MH123199NIMH NIH HHS U01 MH105982NIMH NIH HHS U01 MH114812NIMH NIH HHS U01 MH114819NIMH NIH HHS U01 MH114824NIMH NIH HHS U01 MH114825NIMH NIH HHS U01 MH114828NIMH NIH HHS U01 MH114829NIMH NIH HHS U01 MH116990NIMH NIH HHS U01 MH117023NIMH NIH HHS U01 MH117072NIMH NIH HHS U01 MH117079NIMH NIH HHS U01 MH121260NIMH NIH HHS U01 MH121282NIMH NIH HHS U19 MH114821NIMH NIH HHS U19 MH114830NIMH NIH HHS U19 MH114831NIMH NIH HHS U24 MH114827NINDS NIH HHS R01 NS039600NINDS NIH HHS R01 NS086082NINDS NIH HHS R01 NS110767NINDS NIH HHS R33 NS115183NINDS NIH HHS R61 NS115183
6 · The paper itself

Abstract

Here we report the generation of a multimodal cell census and atlas of the mammalian primary motor cortex as the initial product of the BRAIN Initiative Cell Census Network (BICCN). This was achieved by coordinated large-scale analyses of single-cell transcriptomes, chromatin accessibility, DNA methylomes, spatially resolved single-cell transcriptomes, morphological and electrophysiological properties and cellular resolution input-output mapping, integrated through cross-modal computational analysis. Our results advance the collective knowledge and understanding of brain cell-type organization

Indexed as

Single-Cell AnalysisAnimalsAtlases as TopicCallithrixEpigenomicsFemaleGene Expression ProfilingGlutamatesHumansIn Situ Hybridization, FluorescenceMaleMiceMotor CortexNeuronsOrgan SpecificityPhylogenyGlutamates

Identifiers

PMID34616075
PMCPMC8494634

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.