Evidence map›Paper›PMID 34616072›Full record

ArticleNature2021

Morphological diversity of single neurons in molecularly defined cell types.

Hanchuan Peng, Peng Xie, Lijuan Liu, Xiuli Kuang, Yimin Wang, Lei Qu, Hui Gong, Shengdian Jiang, Anan Li, Zongcai Ruan and 68 more

Abstract read
In one paragraph

Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 250 papers.

0numbers the graph read from it
0cells of the map it votes in
250citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

250 citing papers in PubMed.

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  11. Cell-Type-Specific Synaptic Scaling Mechanisms Differentially Contribute to Associative Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
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  18. Article
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  20. Article

190 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

78 authors.

Hanchuan Peng *Allen Institute for Brain Science, Seattle, WA, USA. h@braintell.org.ORCID http://orcid.org/0000-0002-3478-3942
Peng Xie *SEU-ALLEN Joint Center, Institute for Brain and Intelligence, Southeast University, Nanjing, China.
Lijuan Liu *SEU-ALLEN Joint Center, Institute for Brain and Intelligence, Southeast University, Nanjing, China.
Xiuli KuangSchool of Optometry and Ophthalmology, Wenzhou Medical University, Wenzhou, China.
Yimin WangSEU-ALLEN Joint Center, Institute for Brain and Intelligence, Southeast University, Nanjing, China.ORCID http://orcid.org/0000-0003-2515-6602
Lei QuSEU-ALLEN Joint Center, Institute for Brain and Intelligence, Southeast University, Nanjing, China.ORCID http://orcid.org/0000-0002-2129-5253
Hui GongBritton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, MoE Key Laboratory for Biomedical Photonics, Huazhong University of Science and Technology, Wuhan, China.ORCID http://orcid.org/0000-0001-5519-6248
Shengdian JiangSEU-ALLEN Joint Center, Institute for Brain and Intelligence, Southeast University, Nanjing, China.ORCID http://orcid.org/0000-0002-2277-263X
Anan LiBritton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, MoE Key Laboratory for Biomedical Photonics, Huazhong University of Science and Technology, Wuhan, China.ORCID http://orcid.org/0000-0002-5877-4813
Zongcai RuanSEU-ALLEN Joint Center, Institute for Brain and Intelligence, Southeast University, Nanjing, China.
Liya DingSEU-ALLEN Joint Center, Institute for Brain and Intelligence, Southeast University, Nanjing, China.
Zizhen YaoAllen Institute for Brain Science, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-9361-5607
Chao ChenSchool of Optometry and Ophthalmology, Wenzhou Medical University, Wenzhou, China.
Mengya ChenSchool of Computer Engineering and Science, Shanghai University, Shanghai, China.
Tanya L DaigleAllen Institute for Brain Science, Seattle, WA, USA.
Rachel DalleyAllen Institute for Brain Science, Seattle, WA, USA.
Zhangcan DingSEU-ALLEN Joint Center, Institute for Brain and Intelligence, Southeast University, Nanjing, China.
Yanjun DuanSEU-ALLEN Joint Center, Institute for Brain and Intelligence, Southeast University, Nanjing, China.
Aaron FeinerAllen Institute for Brain Science, Seattle, WA, USA.
Ping HeSchool of Computer Engineering and Science, Shanghai University, Shanghai, China.
Chris HillAllen Institute for Brain Science, Seattle, WA, USA.
Karla E HirokawaAllen Institute for Brain Science, Seattle, WA, USA.
Guodong HongSEU-ALLEN Joint Center, Institute for Brain and Intelligence, Southeast University, Nanjing, China.
Lei HuangSEU-ALLEN Joint Center, Institute for Brain and Intelligence, Southeast University, Nanjing, China.
Sara KebedeAllen Institute for Brain Science, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-3775-1583
Hsien-Chi KuoAllen Institute for Brain Science, Seattle, WA, USA.
Rachael LarsenAllen Institute for Brain Science, Seattle, WA, USA.
Phil LesnarAllen Institute for Brain Science, Seattle, WA, USA.
Longfei LiKey Laboratory of Intelligent Computation and Signal Processing, Ministry of Education, Anhui University, Hefei, China.
Qi LiSchool of Computer Engineering and Science, Shanghai University, Shanghai, China.
Xiangning LiBritton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, MoE Key Laboratory for Biomedical Photonics, Huazhong University of Science and Technology, Wuhan, China.
Yaoyao LiSchool of Optometry and Ophthalmology, Wenzhou Medical University, Wenzhou, China.
Yuanyuan LiKey Laboratory of Intelligent Computation and Signal Processing, Ministry of Education, Anhui University, Hefei, China.
An LiuSEU-ALLEN Joint Center, Institute for Brain and Intelligence, Southeast University, Nanjing, China.ORCID http://orcid.org/0000-0003-0421-8050
Donghuan LuTencent Jarvis Lab, Shenzhen, China.
Stephanie MokAllen Institute for Brain Science, Seattle, WA, USA.
Lydia NgAllen Institute for Brain Science, Seattle, WA, USA.
Thuc Nghi NguyenAllen Institute for Brain Science, Seattle, WA, USA.
Qiang OuyangSEU-ALLEN Joint Center, Institute for Brain and Intelligence, Southeast University, Nanjing, China.
Jintao PanSEU-ALLEN Joint Center, Institute for Brain and Intelligence, Southeast University, Nanjing, China.
Elise ShenAllen Institute for Brain Science, Seattle, WA, USA.
Yuanyuan SongSEU-ALLEN Joint Center, Institute for Brain and Intelligence, Southeast University, Nanjing, China.
Susan M SunkinAllen Institute for Brain Science, Seattle, WA, USA.
Bosiljka TasicAllen Institute for Brain Science, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-6861-4506
Matthew B VeldmanCenter for Neurobehavioral Genetics, Jane and Terry Semel Institute for Neuroscience and Human Behavior, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Wayne WakemanAllen Institute for Brain Science, Seattle, WA, USA.
Wan WanKey Laboratory of Intelligent Computation and Signal Processing, Ministry of Education, Anhui University, Hefei, China.
Peng WangSchool of Computer Engineering and Science, Shanghai University, Shanghai, China.
Quanxin WangAllen Institute for Brain Science, Seattle, WA, USA.
Tao WangKey Laboratory of Intelligent Computation and Signal Processing, Ministry of Education, Anhui University, Hefei, China.
Yaping WangSEU-ALLEN Joint Center, Institute for Brain and Intelligence, Southeast University, Nanjing, China.
Feng XiongSEU-ALLEN Joint Center, Institute for Brain and Intelligence, Southeast University, Nanjing, China.
Wei XiongSchool of Optometry and Ophthalmology, Wenzhou Medical University, Wenzhou, China.
Wenjie XuAllen Institute for Brain Science, Seattle, WA, USA.
Min YeSchool of Optometry and Ophthalmology, Wenzhou Medical University, Wenzhou, China.
Lulu YinSEU-ALLEN Joint Center, Institute for Brain and Intelligence, Southeast University, Nanjing, China.
Yang YuAllen Institute for Brain Science, Seattle, WA, USA.
Jia YuanSEU-ALLEN Joint Center, Institute for Brain and Intelligence, Southeast University, Nanjing, China.
Jing YuanBritton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, MoE Key Laboratory for Biomedical Photonics, Huazhong University of Science and Technology, Wuhan, China.ORCID http://orcid.org/0000-0001-9050-4496
Zhixi YunSEU-ALLEN Joint Center, Institute for Brain and Intelligence, Southeast University, Nanjing, China.
Shaoqun ZengBritton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, MoE Key Laboratory for Biomedical Photonics, Huazhong University of Science and Technology, Wuhan, China.
Shichen ZhangSEU-ALLEN Joint Center, Institute for Brain and Intelligence, Southeast University, Nanjing, China.
Sujun ZhaoSEU-ALLEN Joint Center, Institute for Brain and Intelligence, Southeast University, Nanjing, China.
Zijun ZhaoSEU-ALLEN Joint Center, Institute for Brain and Intelligence, Southeast University, Nanjing, China.
Zhi ZhouAllen Institute for Brain Science, Seattle, WA, USA.
Z Josh HuangCold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.ORCID http://orcid.org/0000-0003-0592-028X
Luke EspositoAllen Institute for Brain Science, Seattle, WA, USA.
Michael J HawrylyczAllen Institute for Brain Science, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-5741-8024
Staci A SorensenAllen Institute for Brain Science, Seattle, WA, USA.
X William YangCenter for Neurobehavioral Genetics, Jane and Terry Semel Institute for Neuroscience and Human Behavior, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0003-3705-7935
Yefeng ZhengTencent Jarvis Lab, Shenzhen, China.
Zhongze GuSEU-ALLEN Joint Center, Institute for Brain and Intelligence, Southeast University, Nanjing, China.ORCID http://orcid.org/0000-0001-8926-7710
Wei XieSEU-ALLEN Joint Center, Institute for Brain and Intelligence, Southeast University, Nanjing, China.ORCID http://orcid.org/0000-0002-9179-4787
Christof KochAllen Institute for Brain Science, Seattle, WA, USA.ORCID http://orcid.org/0000-0001-6482-8067
Qingming LuoBritton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, MoE Key Laboratory for Biomedical Photonics, Huazhong University of Science and Technology, Wuhan, China.
Julie A HarrisAllen Institute for Brain Science, Seattle, WA, USA.
Yun WangAllen Institute for Brain Science, Seattle, WA, USA.
Hongkui ZengAllen Institute for Brain Science, Seattle, WA, USA. hongkuiz@alleninstitute.org.ORCID http://orcid.org/0000-0002-0326-5878

Funding

Generation of novel cell type specific mouse genetic toolsU19MH114830 · NIMH · ALLEN INSTITUTE · PI ZENG, HONGKUI · 2017 to 2021
$64.7M
Establishing a Comprehensive and Standardized Cell Type Characterization PlatformU01MH105982 · NIMH · ALLEN INSTITUTE · PI ANDERSON, DAVID J, ZENG, HONGKUI · 2014 to 2016
$5.1M
Dendritome mapping of genetically-defined and sparsely-labeled cortical and striatal projection neuronsU01MH117079 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DONG, HONG-WEI, YANG, XIANGDONG WILLIAM · 2018 to 2022
$4.3M
High-throughput robotic analysis of integrated neuronal phenotypesR01EY023173 · NEI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BOYDEN, EDWARD S., FOREST, CRAIG · 2012 to 2016
$4.3M
Novel Genetic Strategy for Sparse Labeling and Manipulation of Mammalian NeuronsU01MH106008 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI YANG, XIANGDONG WILLIAM · 2014 to 2016
$2.0M
NEI NIH HHS R01 EY023173NIMH NIH HHS U01 MH105982NIMH NIH HHS U01 MH106008NIMH NIH HHS U01 MH117079NIMH NIH HHS U19 MH114830
6 · The paper itself

Abstract

Dendritic and axonal morphology reflects the input and output of neurons and is a defining feature of neuronal types

Indexed as

Cell ShapeSingle-Cell AnalysisAtlases as TopicBiomarkersBrainGene Expression Regulation, DevelopmentalHumansNeocortexNeurogenesisNeurogliaNeuronsReproducibility of ResultsRNA-SeqBiomarkers

Identifiers

PMID34616072
PMCPMC8494643

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.