ArticleNature2021
Human neocortical expansion involves glutamatergic neuron diversification.
Erratum issuedOpen access · hybridAbstract read
In one paragraph
Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 193 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
193citing papers in PubMed, 1 pooled it
18.9field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
193 citing papers in PubMed, 1 synthesis or guideline pooled it, 307 citations in OpenAlex.
- Building on a Solid Foundation: Adding Relevance and Reproducibility to Neurological Modeling Using Human Pluripotent Stem Cells.Frontiers in cellular neuroscience · 2021Pooled it
- Adaptive Network Stabilization Despite Profound Structural Reorganization in Human Organotypic Cultures.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Distinct single-nucleus RNA-seq changes among non-neuronal cells in ADNC, LATE-NC, and mixed pathologies.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- A framework for comparative analysis of human and mouse cortical neuron dendrites in corresponding brain regions.Nature neuroscience · 2026Article
- Regional specialization of upper-layer inhibitory interneuron organization in the human prefrontal cortex.Journal of anatomy · 2026Article
- Early fate diversification of radial glial progenitors during corticogenesis.Science advances · 2026Article
- Interspecific diversity in the neuronal composition of the mammalian cortex arises from heterochrony in neurogenesis.The EMBO journal · 2026Article
- An atlas of primate insular cortex reveals a signal-processing strategy in von Economo neurons.Nature cell biology · 2026Article
- Modeling Epilepsies with Human Brain Organoids: Recent Advances and Ongoing Challenges.Epilepsy currents · 2026Review
- Multimodal atlas of single neuron metabolic electrophysiological coupling uncovers circadian rewiring.iScience · 2026Article
- Single-cell transcriptomic atlas of frontoinsular cortex reveals molecular correlates of selective neuronal vulnerability in FTD.bioRxiv : the preprint server for biology · 2026Article
- Dendritic morphology and synaptic nonlinearities enhance functional complexity in human cortical neurons.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- DuBois-Reymond prize lecture 2024: Multi-neuron patch-clamp to uncover the neuronal and synaptic physiology in the human neocortex.Pflugers Archiv : European journal of physiology · 2026Article
- Article
- The primate claustrum as a hub for precision weighting of prediction errors across the cortical hierarchy.PLoS biology · 2026Article
- Genomic sequence evolution underlying human neocortical interareal diversification.Genome biology · 2026Article
- Molecular and cellular correlates of human cortical lateralization.Communications biology · 2026Article
- Intrinsic neuronal diversity as a substrate for cortical area specialization in primate vision.Nature communications · 2026Article
- Combined patch-clamp electrophysiology and single-cell genomic analysis reveal spiking tumor cells at the neocortical glioblastoma interface in humans.Neuro-oncology · 2026Article
- Multi-omics profiling reveals MAGEL2-driven defects in human corticogenesis shared across Prader-Willi and Schaaf-Yang syndromes.bioRxiv : the preprint server for biology · 2026Article
133 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
147 authors at 8 institutions in 4 countries.
Jim Berg *Allen Institute for Brain Science, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-3300-5399
Staci A Sorensen *Allen Institute for Brain Science, Seattle, WA, USA.
Jonathan T Ting *Allen Institute for Brain Science, Seattle, WA, USA.
Jeremy A Miller *Allen Institute for Brain Science, Seattle, WA, USA.ORCID http://orcid.org/0000-0003-4549-588X
Thomas ChartrandAllen Institute for Brain Science, Seattle, WA, USA.
Anatoly BuchinAllen Institute for Brain Science, Seattle, WA, USA.
Trygve E BakkenAllen Institute for Brain Science, Seattle, WA, USA.ORCID http://orcid.org/0000-0003-3373-7386
Agata BudzilloAllen Institute for Brain Science, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-2723-3272
Nick DeeAllen Institute for Brain Science, Seattle, WA, USA.
Song-Lin DingAllen Institute for Brain Science, Seattle, WA, USA.
Nathan W GouwensAllen Institute for Brain Science, Seattle, WA, USA.ORCID http://orcid.org/0000-0001-8429-4090
Rebecca D HodgeAllen Institute for Brain Science, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-5784-9668
Brian KalmbachAllen Institute for Brain Science, Seattle, WA, USA.ORCID http://orcid.org/0000-0003-3136-8097
Changkyu LeeAllen Institute for Brain Science, Seattle, WA, USA.
Brian R LeeAllen Institute for Brain Science, Seattle, WA, USA.
Lauren AlfilerAllen Institute for Brain Science, Seattle, WA, USA.
Katherine BakerAllen Institute for Brain Science, Seattle, WA, USA.
Eliza BarkanAllen Institute for Brain Science, Seattle, WA, USA.
Allison BellerDepartment of Pathology, University of Washington, Seattle, WA, USA.
Kyla BerryAllen Institute for Brain Science, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-0632-6322
Darren BertagnolliAllen Institute for Brain Science, Seattle, WA, USA.
Kris BickleyAllen Institute for Brain Science, Seattle, WA, USA.
Jasmine BombenAllen Institute for Brain Science, Seattle, WA, USA.
Thomas Braunbyte physics, Berlin, Germany.
Krissy BrounerAllen Institute for Brain Science, Seattle, WA, USA.
Tamara CasperAllen Institute for Brain Science, Seattle, WA, USA.
Peter ChongAllen Institute for Brain Science, Seattle, WA, USA.
Kirsten CrichtonAllen Institute for Brain Science, Seattle, WA, USA.
Rachel DalleyAllen Institute for Brain Science, Seattle, WA, USA.
Rebecca de FratesAllen Institute for Brain Science, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-7820-093X
Tsega DestaAllen Institute for Brain Science, Seattle, WA, USA.
Samuel Dingman LeeAllen Institute for Brain Science, Seattle, WA, USA.
Florence D'OraziAllen Institute for Brain Science, Seattle, WA, USA.
Nadezhda DotsonAllen Institute for Brain Science, Seattle, WA, USA.
Tom EgdorfAllen Institute for Brain Science, Seattle, WA, USA.
Rachel EnstromAllen Institute for Brain Science, Seattle, WA, USA.
Colin FarrellAllen Institute for Brain Science, Seattle, WA, USA.
David FengAllen Institute for Brain Science, Seattle, WA, USA.
Olivia FongAllen Institute for Brain Science, Seattle, WA, USA.
Szabina FurdanMTA-SZTE Research Group for Cortical Microcircuits, Department of Physiology, Anatomy, and Neuroscience, University of Szeged, Szeged, Hungary.
Anna A GalakhovaDepartment of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research (CNCR), Vrije Universiteit, Amsterdam, The Netherlands.
Clare GamlinAllen Institute for Brain Science, Seattle, WA, USA.
Amanda GaryAllen Institute for Brain Science, Seattle, WA, USA.
Alexandra GlandonAllen Institute for Brain Science, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-1539-3332
Jeff GoldyAllen Institute for Brain Science, Seattle, WA, USA.
Melissa GorhamAllen Institute for Brain Science, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-6770-9474
Natalia A GoriounovaDepartment of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research (CNCR), Vrije Universiteit, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0002-5917-983X
Sergey GratiyAllen Institute for Brain Science, Seattle, WA, USA.
Lucas GraybuckAllen Institute for Brain Science, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-8814-6818
Hong GuAllen Institute for Brain Science, Seattle, WA, USA.
Kristen HadleyAllen Institute for Brain Science, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-4504-8724
Nathan HansenSwedish Neuroscience Institute, Seattle, WA, USA.
Tim S HeistekDepartment of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research (CNCR), Vrije Universiteit, Amsterdam, The Netherlands.
Alex M HenryAllen Institute for Brain Science, Seattle, WA, USA.
Djai B HeyerDepartment of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research (CNCR), Vrije Universiteit, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0002-8118-1450
DiJon HillAllen Institute for Brain Science, Seattle, WA, USA.
Chris HillAllen Institute for Brain Science, Seattle, WA, USA.
Madie HuppAllen Institute for Brain Science, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-7444-5286
Tim JarskyAllen Institute for Brain Science, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-4399-539X
Sara KebedeAllen Institute for Brain Science, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-3775-1583
Lisa KeeneDepartment of Pathology, University of Washington, Seattle, WA, USA.
Lisa KimAllen Institute for Brain Science, Seattle, WA, USA.
Mean-Hwan KimAllen Institute for Brain Science, Seattle, WA, USA.
Matthew KrollAllen Institute for Brain Science, Seattle, WA, USA.
Caitlin LatimerDepartment of Pathology, University of Washington, Seattle, WA, USA.
Boaz P LeviAllen Institute for Brain Science, Seattle, WA, USA.
Katherine E LinkAllen Institute for Brain Science, Seattle, WA, USA.
Matthew MalloryAllen Institute for Brain Science, Seattle, WA, USA.
Rusty MannAllen Institute for Brain Science, Seattle, WA, USA.
Desiree MarshallDepartment of Pathology, University of Washington, Seattle, WA, USA.
Michelle MaxwellAllen Institute for Brain Science, Seattle, WA, USA.
Medea McGrawAllen Institute for Brain Science, Seattle, WA, USA.
Delissa McMillenAllen Institute for Brain Science, Seattle, WA, USA.
Erica MeliefDepartment of Pathology, University of Washington, Seattle, WA, USA.
Eline J MertensDepartment of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research (CNCR), Vrije Universiteit, Amsterdam, The Netherlands.
Leona MezeiMTA-SZTE Research Group for Cortical Microcircuits, Department of Physiology, Anatomy, and Neuroscience, University of Szeged, Szeged, Hungary.
Norbert MihutMTA-SZTE Research Group for Cortical Microcircuits, Department of Physiology, Anatomy, and Neuroscience, University of Szeged, Szeged, Hungary.ORCID http://orcid.org/0000-0002-6432-3656
Stephanie MokAllen Institute for Brain Science, Seattle, WA, USA.
Gabor MolnarMTA-SZTE Research Group for Cortical Microcircuits, Department of Physiology, Anatomy, and Neuroscience, University of Szeged, Szeged, Hungary.ORCID http://orcid.org/0000-0001-7959-139X
Alice MukoraAllen Institute for Brain Science, Seattle, WA, USA.
Lindsay NgAllen Institute for Brain Science, Seattle, WA, USA.
Kiet NgoAllen Institute for Brain Science, Seattle, WA, USA.
Philip R NicovichAllen Institute for Brain Science, Seattle, WA, USA.
Julie NyhusAllen Institute for Brain Science, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-2006-8235
Gaspar OlahMTA-SZTE Research Group for Cortical Microcircuits, Department of Physiology, Anatomy, and Neuroscience, University of Szeged, Szeged, Hungary.
Aaron OldreAllen Institute for Brain Science, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-4969-8759
Victoria OmsteadAllen Institute for Brain Science, Seattle, WA, USA.
Attila OzsvarMTA-SZTE Research Group for Cortical Microcircuits, Department of Physiology, Anatomy, and Neuroscience, University of Szeged, Szeged, Hungary.
Daniel ParkAllen Institute for Brain Science, Seattle, WA, USA.
Hanchuan PengAllen Institute for Brain Science, Seattle, WA, USA.
Trangthanh PhamAllen Institute for Brain Science, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-4738-5062
Christina A PomAllen Institute for Brain Science, Seattle, WA, USA.
Lydia PotekhinaAllen Institute for Brain Science, Seattle, WA, USA.
Ramkumar RajanbabuAllen Institute for Brain Science, Seattle, WA, USA.
Shea RansfordAllen Institute for Brain Science, Seattle, WA, USA.
David ReidAllen Institute for Brain Science, Seattle, WA, USA.
Christine RimorinAllen Institute for Brain Science, Seattle, WA, USA.
Augustin RuizAllen Institute for Brain Science, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-8361-5152
David SandmanAllen Institute for Brain Science, Seattle, WA, USA.
Josef SulcAllen Institute for Brain Science, Seattle, WA, USA.
Susan M SunkinAllen Institute for Brain Science, Seattle, WA, USA.
Aaron SzaferAllen Institute for Brain Science, Seattle, WA, USA.
Viktor SzemenyeiMTA-SZTE Research Group for Cortical Microcircuits, Department of Physiology, Anatomy, and Neuroscience, University of Szeged, Szeged, Hungary.
Elliot R ThomsenAllen Institute for Brain Science, Seattle, WA, USA.ORCID http://orcid.org/0000-0001-9092-8678
Michael TieuAllen Institute for Brain Science, Seattle, WA, USA.
Amy TorkelsonAllen Institute for Brain Science, Seattle, WA, USA.
Jessica TrinhAllen Institute for Brain Science, Seattle, WA, USA.
Herman TungAllen Institute for Brain Science, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-0812-3318
Wayne WakemanAllen Institute for Brain Science, Seattle, WA, USA.
Femke WaleboerDepartment of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research (CNCR), Vrije Universiteit, Amsterdam, The Netherlands.
Katelyn WardAllen Institute for Brain Science, Seattle, WA, USA.
René WilbersDepartment of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research (CNCR), Vrije Universiteit, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0002-6743-2188
Grace WilliamsAllen Institute for Brain Science, Seattle, WA, USA.
Zizhen YaoAllen Institute for Brain Science, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-9361-5607
Jae-Geun YoonSwedish Neuroscience Institute, Seattle, WA, USA.
Costas AnastassiouAllen Institute for Brain Science, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-6793-0611
Anton ArkhipovAllen Institute for Brain Science, Seattle, WA, USA.
Pal BarzoDepartment of Neurosurgery, University of Szeged, Szeged, Hungary.
Amy BernardAllen Institute for Brain Science, Seattle, WA, USA.ORCID http://orcid.org/0000-0003-2540-1153
Charles CobbsSwedish Neuroscience Institute, Seattle, WA, USA.
Philip C de Witt HamerCancer Center Amsterdam, Brain Tumor Center, Department of Neurosurgery, Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0003-2988-8544
Richard G EllenbogenDepartment of Neurological Surgery, University of Washington, Seattle, WA, USA.
Luke EspositoAllen Institute for Brain Science, Seattle, WA, USA.
Manuel FerreiraDepartment of Neurological Surgery, University of Washington, Seattle, WA, USA.
Ryder P GwinnSwedish Neuroscience Institute, Seattle, WA, USA.
Michael J HawrylyczAllen Institute for Brain Science, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-5741-8024
Patrick R HofNash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Sander IdemaCancer Center Amsterdam, Brain Tumor Center, Department of Neurosurgery, Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands.
Allan R JonesAllen Institute for Brain Science, Seattle, WA, USA.
C Dirk KeeneDepartment of Pathology, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-5291-1469
Andrew L KoDepartment of Neurological Surgery, University of Washington, Seattle, WA, USA.
Gabe J MurphyAllen Institute for Brain Science, Seattle, WA, USA.
Lydia NgAllen Institute for Brain Science, Seattle, WA, USA.
Jeffrey G OjemannDepartment of Neurological Surgery, University of Washington, Seattle, WA, USA.
Anoop P PatelDepartment of Neurological Surgery, University of Washington, Seattle, WA, USA.
John W PhillipsAllen Institute for Brain Science, Seattle, WA, USA.
Daniel L SilbergeldDepartment of Neurological Surgery, University of Washington, Seattle, WA, USA.
Kimberly SmithAllen Institute for Brain Science, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-3142-1970
Bosiljka TasicAllen Institute for Brain Science, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-6861-4506
Rafael YusteNeuroTechnology Center, Columbia University, New York, NY, USA.
Idan SegevEdmond and Lily Safra Center for Brain Sciences and Department of Neurobiology, The Hebrew University Jerusalem, Jerusalem, Israel.
Christiaan P J de KockDepartment of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research (CNCR), Vrije Universiteit, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0002-6697-0179
Huibert D MansvelderDepartment of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research (CNCR), Vrije Universiteit, Amsterdam, The Netherlands.
Gabor TamasMTA-SZTE Research Group for Cortical Microcircuits, Department of Physiology, Anatomy, and Neuroscience, University of Szeged, Szeged, Hungary.ORCID http://orcid.org/0000-0002-7905-6001
Hongkui ZengAllen Institute for Brain Science, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-0326-5878
Christof KochAllen Institute for Brain Science, Seattle, WA, USA.ORCID http://orcid.org/0000-0001-6482-8067
Ed S LeinAllen Institute for Brain Science, Seattle, WA, USA. Edl@alleninstitute.org.ORCID http://orcid.org/0000-0001-9012-6552
Allen Institute for Brain Science · USUniversity of Washington · USUniversity of Szeged · HUVrije Universiteit Amsterdam · NLSwedish Medical Center · USAmsterdam University Medical Centers · NLColumbia University · USHebrew University of Jerusalem · IL
Funding
Generation of novel cell type specific mouse genetic toolsU19MH114830 · NIMH · ALLEN INSTITUTE · PI ZENG, HONGKUI · 2017 to 2021
$64.7MUniversity of Washington Alzheimer's Disease Research CenterP30AG066509 · NIA · UNIVERSITY OF WASHINGTON · PI Thomas J. Grabowski · 2020 to 2026
$29.0MA multimodal atlas of human brain cell typesU01MH114812 · NIMH · ALLEN INSTITUTE · PI LEIN, ED · 2017 to 2021
$19.2MEstablishing a Comprehensive and Standardized Cell Type Characterization PlatformU01MH105982 · NIMH · ALLEN INSTITUTE · PI ANDERSON, DAVID J, ZENG, HONGKUI · 2014 to 2016
$5.1MHigh-throughput robotic analysis of integrated neuronal phenotypesR01EY023173 · NEI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BOYDEN, EDWARD S., FOREST, CRAIG · 2012 to 2016
$4.3MMozak: Creating an Expert Community to accelerate neuronal reconstruction at scaleR01MH116247 · NIMH · UNIVERSITY OF WASHINGTON · PI POPOVIC, ZORAN · 2018 to 2022
$3.1MMulti-modal, large-scale characterization of cellular and cell-type-specific effects with electric stimulation in rodent and human brainR01NS120300 · NINDS · ALLEN INSTITUTE · PI LEE, SOO YEUN · 2020 to 2024
$2.8MNEI NIH HHS R01 EY023173NIA NIH HHS P30 AG066509NIMH NIH HHS R01 MH116247NIMH NIH HHS U01 MH105982NIMH NIH HHS U01 MH114812NIMH NIH HHS U19 MH114830NINDS NIH HHS R01 NS120300
Abstract
The neocortex is disproportionately expanded in human compared with mouse
Indexed as
Alzheimer DiseaseAnimalsCell ShapeCollagenElectrophysiologyExtracellular Matrix ProteinsFemaleGlutamic AcidHumansLysineMaleMiceNeocortexNeuronsPatch-Clamp TechniquesTranscriptomebiocytinCOL22A1 protein, humanCollagenExtracellular Matrix ProteinsFREM3 protein, humanGlutamic AcidLysine
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