ArticleNature2021
Single-cell epigenomics reveals mechanisms of human cortical development.
Open access · hybridAbstract read
In one paragraph
Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 189 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
189citing papers in PubMed, 1 pooled it
16.9field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
189 citing papers in PubMed, 1 synthesis or guideline pooled it, 287 citations in OpenAlex.
- Genetic insights into human cortical organization and development through genome-wide analyses of 2,347 neuroimaging phenotypes.Nature genetics · 2023Pooled it
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- Cortical organoids reveal human-specific role of METTL5 in neurodevelopment via regulation of CHCHD2.Stem cell reports · 2026Article
- Morphogen-guided neocortical organoids with anteroposterior areal identity.Cell stem cell · 2026Article
- Functional development of midbrain and pons during human gestation and electrophysiological markers for DS intervention.Journal of advanced research · 2026Article
- Tissue-resident immune cells drive genetic risk in autoimmune and lung diseases.Nature immunology · 2026Article
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- Distinct differentiation trajectories leave lasting impacts on gene regulation and function of V2a neurons.Nature communications · 2026Article
- Anti-asthma drug montelukast induces autistic behaviors via disrupting neuronal retinoic acid signaling.Signal transduction and targeted therapy · 2026Article
- Convergent re-evolution of CNS structures: focus on the fovea.Current opinion in genetics & development · 2026Review
- Neural stem cell epigenomes and fate bias are temporally coordinated during mouse cortical development.Genes & development · 2026Article
- A scalable Tn5-based method for genome-wide DNA methylation profiling in development and disease.Nature communications · 2026Article
- Intrinsic coordination of dynamic molecular signatures shape the human prefrontal cortex.bioRxiv : the preprint server for biology · 2026Article
- Excitatory neurons and astrocytes-specific dysregulation and aberrant interactions are vulnerable to FCDI as suggested by single-cell spatial transcriptomics.Clinical and translational medicine · 2026Article
- STEER: decoupling kinetics with Spatial-Temporal Explainable Expert model for RNA velocity inference.National science review · 2026Article
- A single-cell multiomic analysis identifies molecular and gene-regulatory mechanisms dysregulated in developing Down syndrome neocortex.Science (New York, N.Y.) · 2026Article
129 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 8 institutions in 1 country.
Ryan S ZiffraDepartment of Anatomy, University of California, San Francisco, San Francisco, CA, USA.
Chang N KimDepartment of Anatomy, University of California, San Francisco, San Francisco, CA, USA.
Jayden M RossDepartment of Anatomy, University of California, San Francisco, San Francisco, CA, USA.
Amy WilfertDepartment of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA.ORCID http://orcid.org/0000-0001-8590-222X
Tychele N TurnerDepartment of Genetics, Washington University School of Medicine, St. Louis, MO, USA.ORCID http://orcid.org/0000-0001-8246-6477
Maximilian HaeusslerGenomics Institute, University of California, Santa Cruz, Santa Cruz, CA, USA.ORCID http://orcid.org/0000-0001-8721-8253
Alex M CasellaInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.
Pawel F PrzytyckiGladstone Institutes, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-3360-6936
Kathleen C KeoughInstitute for Computational Health Sciences, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-7481-0511
David ShinDepartment of Anatomy, University of California, San Francisco, San Francisco, CA, USA.
Derek BogdanoffDepartment of Anatomy, University of California, San Francisco, San Francisco, CA, USA.
Anat KreimerDepartment of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, USA.
Katherine S PollardGladstone Institutes, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-9870-6196
Seth A AmentInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0001-6443-7509
Evan E EichlerDepartment of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-8246-4014
Nadav AhituvDepartment of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-7434-8144
Tomasz J NowakowskiDepartment of Anatomy, University of California, San Francisco, San Francisco, CA, USA. tomasz.nowakowski@ucsf.edu.ORCID http://orcid.org/0000-0003-2345-4964
University of California, San Francisco · USUniversity of Maryland, Baltimore · USGladstone Institutes · USHoward Hughes Medical Institute · USQB3 · USUniversity of California, Santa Cruz · USUniversity of Washington · USWashington University in St. Louis · US
Funding
The UCSC Genome BrowserU41HG002371 · NHGRI · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI KENT, WILLIAM JAMES · 2012 to 2021
$36.6MThe Psychiatric Cell Map Initiative: Connecting Genomics, Subcellular Networks, and Higher Order PhenotypesU01MH115747 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KAMPMANN, MARTIN, KROGAN, NEVAN J · 2018 to 2022
$19.6MThe UCSC Genome BrowserU24HG002371 · NHGRI · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI Maximilian Haeussler · 2022 to 2026
$17.6MSporadic Mutations and Autism Spectrum DisordersR01MH101221 · NIMH · UNIVERSITY OF WASHINGTON · PI EICHLER, EVAN · 2013 to 2025
$9.2MPHARMACEUTICAL SCIENCES AND PHARMACOGENOMICST32GM007175 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AHITUV, NADAV, KROETZ, DEANNA L · 1985 to 2021
$7.1MA Cellular Resolution Census of the Developing Human BrainU01MH114825 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HUANG, ERIC J, KRIEGSTEIN, ARNOLD · 2017 to 2021
$6.7MAssessing Genomic, Regulatory and Transcriptional Variation at Single Nuclei Resolution in the Brains of Individuals with Autism Spectrum DisorderR01MH125516 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ARNOLD KRIEGSTEIN, Tomasz Nowakowski · 2021 to 2026
$3.8MMassively parallel dissection of psychiatric regulatory networksR01MH109907 · NIMH · J. DAVID GLADSTONE INSTITUTES · PI AHITUV, NADAV, POLLARD, KATHERINE S. · 2016 to 2020
$3.4MMassively parallel characterization of psychiatric disease associated regulatory elements in defined cell typesU01MH116438 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AHITUV, NADAV, POLLARD, KATHERINE S. · 2018 to 2021
$2.7MResolving single-cell brain regulatory elements with bulk data supervised modelsR01MH123178 · NIMH · J. DAVID GLADSTONE INSTITUTES · PI POLLARD, KATHERINE S. · 2020 to 2023
$2.4MMapping Developmental Lineage Relationships in the Cerebral CortexRF1MH121268 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI NOWAKOWSKI, TOMASZ · 2019 to 2019
$2.1MA visualization interface for BRAIN single cell data, integrating transcriptomics, epigenomics and spatial assaysRF1MH132662 · NIMH · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI HAEUSSLER, MAXIMILIAN · 2023 to 2023
$866kNHGRI NIH HHS U24 HG002371NHGRI NIH HHS U41 HG002371NIGMS NIH HHS T32 GM007175NIH HHS 1K99 MH117165NIH HHS 5U41 HG002371-19NIMH NIH HHS K99 MH117165NIMH NIH HHS R01 MH101221NIMH NIH HHS R01 MH109907NIMH NIH HHS R01 MH123178NIMH NIH HHS R01 MH125516NIMH NIH HHS RF1 MH121268NIMH NIH HHS RF1 MH132662NIMH NIH HHS U01 MH114825NIMH NIH HHS U01 MH115747NIMH NIH HHS U01 MH116438
Abstract
During mammalian development, differences in chromatin state coincide with cellular differentiation and reflect changes in the gene regulatory landscape
Indexed as
EpigenomicsNeurogenesisSingle-Cell AnalysisAtlases as TopicBrainChromatinDisease SusceptibilityEnhancer Elements, GeneticHumansNeuronsOrganoidsTretinoinChromatinTretinoin
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.