ArticleNature2021
A pan-serotype dengue virus inhibitor targeting the NS3-NS4B interaction.
Erratum issuedOpen access · greenAbstract read
In one paragraph
Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 68 papers.
0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed
25.9field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
68 citing papers in PubMed, 182 citations in OpenAlex.
- Towards broader-spectrum direct-acting antivirals against RNA viruses.Nature reviews. Microbiology · 2026Review
- Oral lipid prodrug V2043 (1-Antimicrobial agents and chemotherapy · 2026Article
- Marine-Derived Natural Products Against Flaviviruses: Mechanisms, Evidence, and Future Directions.Marine drugs · 2026Review
- Antibody-Dependent Enhancement in Flavivirus Infections: From Fc Receptor Signaling to Vaccine and Therapeutic Design.Viruses · 2026Review
- Cross-Family Mechanistic Analysis of Plant Alkaloids Against Neglected Arboviruses and Related RNA Viruses.Molecules (Basel, Switzerland) · 2026Review
- Quantum Pharmacophore-Based Virtual Screening Enables Prospective Discovery of Chemotype-Diverse Dengue NS5 Inhibitors.Journal of chemical information and modeling · 2026Article
- An orthoflavivirus inhibitor targeting multifunctional NS2A protein, a previously unidentified target.PLoS pathogens · 2026Article
- Discovery of a potent anti-Zika virus benzamide series targeting the viral protein NS4B.PLoS pathogens · 2026Article
- Antiviral Strategies Against Dengue Virus: Recent Insights into Compounds Targeting Viral and Host Factors.Current topics in microbiology and immunology · 2026Review
- CpG oligodeoxynucleotides and pan-serotype inhibitors control neurotropic dengue infection in novel immune competent neonatal mouse model.Emerging microbes & infections · 2025Article
- Hepatitis E Virus ORF1 Polyprotein Harbors a Pocket-Like Cavity That Is Vital for Virus Replication and Represents a Novel Antiviral Target.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- A nitrogen-containing diphyllin derivative C156-P1 exhibited broad-spectrum antiviral activity againstAntimicrobial agents and chemotherapy · 2025Article
- Discovery of a potent anti-Zika virus benzamide series targeting the viral protein NS4B.bioRxiv : the preprint server for biology · 2025Article
- Mechanisms and Research Methods of Protein Modification in Virus Entry.Applied biochemistry and biotechnology · 2025Review
- High-throughput crystallographic fragment screening of Zika virus NS3 Helicase.bioRxiv : the preprint server for biology · 2025Article
- Aptamer as a therapeutic agent for dengue infections.Virology journal · 2025Review
- Novel and repurposed antiviral molecules for arbovirus infections with epidemic Potential: A systematic review.New microbes and new infections · 2025Review
- Dengue and Flavivirus Co-Infections: Challenges in Diagnosis, Treatment, and Disease Management.International journal of molecular sciences · 2025Review
- Development of a Noninfectious Japanese Encephalitis Virus Replicon for Antiviral Drug Screening and Gene Function Studies.Viruses · 2025Article
- In Silico Evaluation of Potential Hit Molecules Against Multiple Serotypes of Dengue Virus Envelope Glycoprotein.Molecules (Basel, Switzerland) · 2025Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Commented on by
- Erratum issued
Authors and funding
24 authors at 6 institutions in 5 countries.
Suzanne J F KapteinLaboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.ORCID http://orcid.org/0000-0002-7935-0219
Olivia GoethalsJanssen Global Public Health, Janssen Pharmaceutica, Beerse, Belgium.
Dominik KiemelDepartment of Infectious Diseases, Molecular Virology, Heidelberg University, Heidelberg, Germany.
Arnaud MarchandCistim Leuven, Leuven, Belgium.
Bart KesteleynJanssen Research & Development, Janssen Pharmaceutica, Beerse, Belgium.
Jean-François BonfantiJanssen Infectious Diseases Discovery, Janssen-Cilag, Val de Reuil, France.ORCID http://orcid.org/0000-0002-2107-8857
Dorothée BardiotCistim Leuven, Leuven, Belgium.
Bart StoopsJanssen Research & Development, Janssen Pharmaceutica, Beerse, Belgium.
Tim H M JonckersJanssen Research & Development, Janssen Pharmaceutica, Beerse, Belgium.
Kai DallmeierLaboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.ORCID http://orcid.org/0000-0002-8117-9166
Peggy GeluykensJanssen Research & Development, Janssen Pharmaceutica, Beerse, Belgium.
Kim ThysJanssen Research & Development, Janssen Pharmaceutica, Beerse, Belgium.
Marjolein CrabbeJanssen Research & Development, Janssen Pharmaceutica, Beerse, Belgium.
Laurent Chatel-ChaixDepartment of Infectious Diseases, Molecular Virology, Heidelberg University, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-7390-8250
Max MünsterDepartment of Infectious Diseases, Molecular Virology, Heidelberg University, Heidelberg, Germany.
Gilles QueratUnité des Virus Émergents (UVE), Aix-Marseille Univ, IRD 190 Inserm 1207, IHU Méditerranée Infection, Marseille, France.
Franck TouretUnité des Virus Émergents (UVE), Aix-Marseille Univ, IRD 190 Inserm 1207, IHU Méditerranée Infection, Marseille, France.ORCID http://orcid.org/0000-0002-4734-2249
Xavier de LamballerieUnité des Virus Émergents (UVE), Aix-Marseille Univ, IRD 190 Inserm 1207, IHU Méditerranée Infection, Marseille, France.
Pierre RaboissonJanssen Research & Development, Janssen Pharmaceutica, Beerse, Belgium.
Kenny SimmenJanssen Research & Development, Janssen Pharmaceutica, Beerse, Belgium.
Patrick ChaltinCistim Leuven, Leuven, Belgium.
Ralf BartenschlagerDepartment of Infectious Diseases, Molecular Virology, Heidelberg University, Heidelberg, Germany.ORCID http://orcid.org/0000-0001-5601-9307
Marnix Van LoockJanssen Global Public Health, Janssen Pharmaceutica, Beerse, Belgium. mvloock@its.jnj.com.ORCID http://orcid.org/0000-0003-4151-4588
Johan NeytsLaboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium. johan.neyts@kuleuven.be.ORCID http://orcid.org/0000-0002-0033-7514
Janssen (Belgium) · BEHeidelberg University · DEInserm · FRKU Leuven · BERega Institute for Medical Research · BEJanssen (France) · FR
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dengue virus causes approximately 96 million symptomatic infections annually, manifesting as dengue fever or occasionally as severe dengue
Indexed as
AnimalsAntiviral AgentsDEAD-box RNA HelicasesDengueDengue VirusDisease Models, AnimalFemaleMaleMembrane ProteinsMiceNucleoside-TriphosphataseRNA HelicasesSerine EndopeptidasesViral LoadViral Nonstructural ProteinsViral ProteasesAntiviral AgentsDEAD-box RNA HelicasesMembrane ProteinsNS3 protein, flavivirusNS4B protein, Dengue virusNucleoside-TriphosphataseRNA HelicasesSerine EndopeptidasesViral Nonstructural ProteinsViral Proteases
Identifiers
What OpenQuestion holds
Textmetadata
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.