ArticleNature2021
A single sulfatase is required to access colonic mucin by a gut bacterium.
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In one paragraph
Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 111 papers.
0numbers the graph read from it
0cells of the map it votes in
111citing papers in PubMed
17.9field-weighted citation impact, top 1% of its field
What it found
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Who cites it
111 citing papers in PubMed, 203 citations in OpenAlex.
- Evidence for a Modulatory Effect of a 12-Week Pomegranate Juice Intervention on the Transcriptional Response in Inflammatory Bowel Disease Patients Reducing Fecal Calprotectin Levels: Findings From a Proof-of-Principle Study.Molecular nutrition & food research · 2025Trial
- Article
- Bacterial constipation: Mucin-degrading intestinal commensal bacteria cause constipation.Gut microbes · 2026Article
- Determination of Gene-Level Fitness Contributions Across the Mucin-Utilization Network of Bacteroides thetaiotaomicron.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Ethanol, acetaldehyde, lipopolysaccharide, and neutrophil extracellular traps: four-pronged attack on gut epithelial barrier in alcohol use disorder.Anatomical record (Hoboken, N.J. : 2007) · 2026Review
- Unique adaptations in sulfatases underpin colonic mucin degradation by Akkermansia muciniphila.Nature microbiology · 2026Article
- Extracellular metabolite production byApplied and environmental microbiology · 2026Article
- Fluorogenic Coupled Assays Reveal Catalytic Properties, Inhibition Constants and Cellular Location of Mucin-Active Carbohydrate Sulfatases.Angewandte Chemie (International ed. in English) · 2026Article
- A Microbial Lipid-ATP Synthase Axis Fuels NK Cell Antitumor Activity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Chemoenzymatic Synthesis of AsymmetricJournal of the American Chemical Society · 2026Article
- The microbiome regulates host metabolic health and diseases through microbial enzymes.Nature reviews. Gastroenterology & hepatology · 2026Review
- Application of Post-Glycosylation Modifying Enzymes for Mass Spectrometry Imaging of ModifiedJournal of the American Society for Mass Spectrometry · 2026Article
- Defining substrate specificities ofOrganic chemistry frontiers : an international journal of organic chemistry · 2026Article
- Longitudinal analysis of human milk oligosaccharides and mucin-2-glycans in infants reveals enrichment of sulfated and glucuronic acid-bearing HMOs.The Journal of biological chemistry · 2026Article
- B3GNT7 preserves intestinal barrier integrity: a key defense mechanism against acute pancreatitis progression.Clinical and experimental medicine · 2026Article
- Jejunal and pancreatic transcriptomic adaptations underpin enhanced performance in broilers fed sugarcane bagasse-supplemented diets.BMC genomics · 2026Article
- The butyrate-producing Gram-positive human gut bacterium, Hoskinsella mucinilytica, selectively targets host mucin N-acetylhexosamines.The Journal of biological chemistry · 2026Article
- Article
- Degradation of mucinbioRxiv : the preprint server for biology · 2026Article
- Chondroitin sulfate degradation bolstersbioRxiv : the preprint server for biology · 2026Article
51 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors at 6 institutions in 5 countries.
Ana S LuisDepartment of Microbiology and Immunology, University of Michigan, Ann Arbor, MI, USA. ana.luis@medkem.gu.se.
Chunsheng JinDepartment of Medical Biochemistry, Institute for Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.ORCID http://orcid.org/0000-0002-0229-102X
Gabriel Vasconcelos PereiraDepartment of Microbiology and Immunology, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0001-7937-474X
Robert W P GlowackiDepartment of Microbiology and Immunology, University of Michigan, Ann Arbor, MI, USA.
Sadie R GugelDepartment of Microbiology and Immunology, University of Michigan, Ann Arbor, MI, USA.
Shaleni SinghDepartment of Microbiology and Immunology, University of Michigan, Ann Arbor, MI, USA.
Dominic P ByrneDepartment of Biochemistry and Systems Biology, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.
Nicholas A PudloDepartment of Microbiology and Immunology, University of Michigan, Ann Arbor, MI, USA.
James A LondonDepartment of Biochemistry and Systems Biology, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.
Arnaud BasléInstitute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, UK.
Mark ReihillCentre for Synthesis and Chemical Biology, University College Dublin, Belfield, Dublin, Ireland.ORCID http://orcid.org/0000-0003-3896-9346
Stefan OscarsonCentre for Synthesis and Chemical Biology, University College Dublin, Belfield, Dublin, Ireland.ORCID http://orcid.org/0000-0002-8273-4918
Patrick A EyersDepartment of Biochemistry and Systems Biology, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.ORCID http://orcid.org/0000-0002-9220-2966
Mirjam CzjzekSorbonne Université, Univ Paris 06, CNRS, UMR 8227, Integrative Biology of Marine Models, Roscoff, Bretagne, France.ORCID http://orcid.org/0000-0002-7483-2841
Gurvan MichelSorbonne Université, Univ Paris 06, CNRS, UMR 8227, Integrative Biology of Marine Models, Roscoff, Bretagne, France.
Tristan BarbeyronSorbonne Université, Univ Paris 06, CNRS, UMR 8227, Integrative Biology of Marine Models, Roscoff, Bretagne, France.
Edwin A YatesDepartment of Biochemistry and Systems Biology, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.
Gunnar C HanssonDepartment of Medical Biochemistry, Institute for Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.ORCID http://orcid.org/0000-0002-1900-1869
Niclas G KarlssonDepartment of Medical Biochemistry, Institute for Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.ORCID http://orcid.org/0000-0002-3045-2628
Alan CartmellDepartment of Biochemistry and Systems Biology, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK. alan.cartmell@liverpool.ac.uk.ORCID http://orcid.org/0000-0002-5512-249X
Eric C MartensDepartment of Microbiology and Immunology, University of Michigan, Ann Arbor, MI, USA. emartens@umich.edu.ORCID http://orcid.org/0000-0001-6681-2990
University of Michigan · USUniversity of Liverpool · GBCentre National de la Recherche Scientifique · FRUniversity of Gothenburg · SEUniversity College Dublin · IENewcastle University · GB
Funding
University of Michigan Center for Gastrointestinal ResearchP30DK034933 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI OMARY, BISHR · 1986 to 2021
$22.5MLow dietary fiber and gut microbiota-induced mucus layer erosion as IBD triggersR01DK118024 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GRACE Y. CHEN, Eric C Martens · 2018 to 2026
$4.9MThe MUC2 Mucus Gel as an Innate Immune Mechanism that Inhibits InflammationU01AI095473 · NIAID · GOTEBORG UNIVERSITY · PI HANSSON, GUNNAR C., JOHANSSON, MALIN E.V. · 2011 to 2020
$2.6MCellular Biotechnology Training Program (CBTP) - Years 31-35T32GM145304 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Guizhi Zhu · 2022 to 2026
$2.6MUnraveling the enzymatic pathway of gut bacterial mucus degradation to treat inflammationR01DK125445 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KOROPATKIN, NICOLE M, MARTENS, ERIC C · 2020 to 2023
$2.2MAcademy of Medical SciencesEuropean Research CouncilNIAID NIH HHS U01 AI095473NIDDK NIH HHS P30 DK034933NIDDK NIH HHS R01 DK118024NIDDK NIH HHS R01 DK125445NIGMS NIH HHS T32 GM145304NIH HHS 5P30 DK034933NIH HHS DK118024NIH HHS DK125445Wellcome Trust
Abstract
Humans have co-evolved with a dense community of microbial symbionts that inhabit the lower intestine. In the colon, secreted mucus creates a barrier that separates these microorganisms from the intestinal epithelium
Indexed as
Gastrointestinal MicrobiomeAcetylgalactosamineAnimalsBacteroidesColonCrystallography, X-RayFemaleGalactoseHumansMaleMiceModels, MolecularMucinsSubstrate SpecificitySulfatasesAcetylgalactosamineGalactoseMucinsSulfatases
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.