Evidence map›Paper›PMID 34616039›Full record

ArticleNature2021

Neurotoxic reactive astrocytes induce cell death via saturated lipids.

Kevin A Guttenplan, Maya K Weigel, Priya Prakash, Prageeth R Wijewardhane, Philip Hasel, Uriel Rufen-Blanchette, Alexandra E Münch, Jacob A Blum, Jonathan Fine, Mikaela C Neal and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 362 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
362citing papers in PubMed, 1 pooled it
39.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

362 citing papers in PubMed, 1 synthesis or guideline pooled it, 552 citations in OpenAlex.

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  18. A lifespan staging model of basal forebrain cholinergic vulnerability.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Review
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302 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Kevin A GuttenplanDepartment of Neurobiology, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-4242-4349
Maya K Weigel *Department of Neurobiology, Stanford University, Stanford, CA, USA.
Priya Prakash *Department of Chemistry, Purdue University, West Lafayette, IN, USA.ORCID http://orcid.org/0000-0003-2193-9669
Prageeth R WijewardhaneDepartment of Chemistry, Purdue University, West Lafayette, IN, USA.ORCID http://orcid.org/0000-0002-9781-3053
Philip HaselNeuroscience Institute, NYU School of Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0003-4378-3685
Uriel Rufen-BlanchetteNeuroscience Institute, NYU School of Medicine, New York, NY, USA.
Alexandra E MünchDepartment of Neurobiology, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-9609-3277
Jacob A BlumDepartment of Genetics, Stanford University, Stanford, CA, USA.
Jonathan FineDepartment of Chemistry, Purdue University, West Lafayette, IN, USA.
Mikaela C NealUniversity of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Kimberley D BruceUniversity of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Aaron D GitlerDepartment of Genetics, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0001-8603-1526
Gaurav ChopraDepartment of Chemistry, Purdue University, West Lafayette, IN, USA.ORCID http://orcid.org/0000-0003-0942-7898
Shane A LiddelowNeuroscience Institute, NYU School of Medicine, New York, NY, USA. shane.liddelow@nyulangone.org.ORCID http://orcid.org/0000-0002-0840-1437
Ben A BarresDepartment of Neurobiology, Stanford University, Stanford, CA, USA.
Stanford University · USPurdue University West Lafayette · USNeurosciences Institute · USUniversity of Colorado Anschutz Medical Campus · US

Funding

Translational Oncology Research Program (Project-005)P30CA124435 · NCI · STANFORD UNIVERSITY · PI Vittorio Sebastiano · 2007 to 2026
$71.4M
Transgenic Mouse Core Facility Shared Resource (TMCF-SR)P30CA023168 · NCI · PURDUE UNIVERSITY WEST LAFAYETTE · PI Andrea L Kasinski · 1985 to 2026
$43.4M
Quality Assurance and Quality Control Project Management: Improving Submissions and Study Conduct in the Human Subjects Research Prior Approval ProcessUL1TR002529 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI MOE, SHARON M, WIEHE, SARAH ELIZABETH · 2018 to 2022
$27.2M
VECTOR COREP30NS069375 · NINDS · STANFORD UNIVERSITY · PI SHAMLOO, MEHRDAD · 2011 to 2019
$6.3M
LTQ Orbitrap XL ETD Mass SpectrometerS10RR027425 · NCRR · STANFORD UNIVERSITY · PI WANDLESS, THOMAS JAMES · 2010 to 2010
$500k
Microglial Lipoprotein Lipase; a novel therapeutic Target for Alzheimer's diseaseR21AG061549 · NIA · UNIVERSITY OF COLORADO DENVER · PI BRUCE, KIMBERLEY D, ECKEL, ROBERT H · 2019 to 2020
$428k
NCATS NIH HHS UL1 TR002529NCI NIH HHS P30 CA023168NCI NIH HHS P30 CA124435NCRR NIH HHS S10 RR027425NIA NIH HHS R21 AG061549NINDS NIH HHS P30 NS069375
6 · The paper itself

Abstract

Astrocytes regulate the response of the central nervous system to disease and injury and have been hypothesized to actively kill neurons in neurodegenerative disease

Indexed as

AnimalsAstrocytesCell DeathCulture Media, ConditionedFatty Acid ElongasesFemaleGene Knockout TechniquesLipidsMaleMiceMice, KnockoutNeurodegenerative DiseasesNeurotoxinsCulture Media, ConditionedElovl1 protein, mouseFatty Acid ElongasesLipidsNeurotoxins

Identifiers

PMID34616039
PMCPMC12054010
OpenAlexW3201931145

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.