Evidence map›Paper›PMID 34616037›Full record

ArticleNature2021

5-HT modulation of a medial septal circuit tunes social memory stability.

Xiaoting Wu, Wade Morishita, Kevin T Beier, Boris D Heifets, Robert C Malenka

Abstract read
In one paragraph

Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed.

  1. Psilocybin modulates social behaviour in male and female mice in a time-dependent manner.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
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  12. 5-HTMolecular psychiatry · 2025
    Article
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  18. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Xiaoting WuNancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
Wade MorishitaNancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
Kevin T BeierDepartment of Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA.ORCID http://orcid.org/0000-0002-4934-1338
Boris D HeifetsDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-1474-0379
Robert C MalenkaNancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA. malenka@stanford.edu.ORCID http://orcid.org/0000-0002-5428-5211

Funding

Sculpting the brain: High-resolution spatiotemporally-controlled modulation of memoriesDP2AG067666 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI BEIER, KEVIN T, CORDER, GREGORY · 2019 to 2022
$3.1M
Neural circuitry and synaptic physiology underlying MDMA's prosocial effectK08MH110610 · NIMH · STANFORD UNIVERSITY · PI HEIFETS, BORIS DOV · 2017 to 2020
$780k
INVESTIGATING FUNCTION OF NOVEL DRUG-INDUCED SYNAPTIC CHANGES IN THE VTAR00DA041445 · NIDA · UNIVERSITY OF CALIFORNIA-IRVINE · PI BEIER, KEVIN T · 2018 to 2020
$747k
The role of the septum in social memoryR00MH122697 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI WU, XIAOTING · 2022 to 2024
$747k
The role of the septum in social memoryK99MH122697 · NIMH · STANFORD UNIVERSITY · PI WU, XIAOTING · 2020 to 2021
$218k
NIA NIH HHS DP2 AG067666NIDA NIH HHS R00 DA041445NIMH NIH HHS K08 MH110610NIMH NIH HHS K99 MH122697NIMH NIH HHS R00 MH122697
6 · The paper itself

Abstract

Social memory-the ability to recognize and remember familiar conspecifics-is critical for the survival of an animal in its social group

Indexed as

Neural PathwaysSocial BehaviorAnimalsCA2 Region, HippocampalFemaleGlutamic AcidMaleMemoryMiceNeuronal PlasticityOptogeneticsPyramidal CellsReceptor, Serotonin, 5-HT1BSeptal NucleiSerotoninSynapsesGlutamic AcidReceptor, Serotonin, 5-HT1BSerotonin

Identifiers

PMID34616037
PMCPMC9348902

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.