Evidence map›Paper›PMID 34616009›Full record

ArticleSpinal cord2022

Ischemic postconditioning reduces spinal cord ischemia-reperfusion injury through ATP-sensitive potassium channel.

Jia Fu, Guo Mu, Xiangbo Liu, Cehua Ou, Jiaomei Zhao

Abstract read
PubMed Publisher
In one paragraph

Article in Spinal cord, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Jia Fu *Department of Pain Management, Affiliated Hospital of Southwest Medical University, Luzhou, China.
Guo Mu *Department of Anesthesiology, Zigong Fourth People's Hospital, Zigong, China. muguo92@outlook.com.ORCID 0000-0002-1099-6644
Xiangbo LiuDepartment of Pain Management, Affiliated Hospital of Southwest Medical University, Luzhou, China.
Cehua OuDepartment of Pain Management, Affiliated Hospital of Southwest Medical University, Luzhou, China.
Jiaomei ZhaoDepartment of Pain Management, Affiliated Hospital of Southwest Medical University, Luzhou, China. 871656272@qq.com.
Affiliated Hospital of Southwest Medical University · CNZigong First People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

STUDY

designAnimal study.

objectivesExplore the neuroprotective effect of remote limb ischemic postconditioning (Post C) in spinal cord ischemic reperfusion injury (SCII) and related mechanisms.

settingAnesthesiology Laboratory of Southwest Medical University.

methodsWe established a rabbit SCII model and processed it with Post C. To evaluate the neural function, spinal cord tissue was taken 48 h later, normal neurons were evaluated by HE staining, and the expression of ATP-sensitive potassium channel (K

resultsWe observed that Post C significantly improved exercise ability and the number of spinal motor neurons in the SCII model. Microglia are activated and expression of M

conclusionPost C has a neuroprotective effect on SCII, and maybe a protective effect produced by activating K

Indexed as

Ischemic PostconditioningNeuroprotective AgentsReperfusion InjurySpinal Cord InjuriesSpinal Cord IschemiaAdenosine TriphosphateAnimalsKATP ChannelsRabbitsSpinal CordAdenosine TriphosphateKATP ChannelsNeuroprotective Agents

Identifiers

PMID34616009
OpenAlexW3203335362

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.