Evidence map›Paper›PMID 34615975›Full record

ArticleScientific reports2021

Quantification of retinal blood leakage in fundus fluorescein angiography in a retinal angiogenesis model.

Cesar H Comin, Demetrios I Tsirukis, Ye Sun, Xiaoyin Xu

Abstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Article
  3. Automated Assessment of Retinal Vascular Integrity Across Species.Investigative ophthalmology & visual science · 2025
    Article
  4. Article
  5. In Vivo Imaging of Rodent Retina in Retinal Disease.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  6. Review
  7. Review
  8. Review
  9. Review
  10. Review
  11. Article
  12. Article
  13. Multimodal imaging of experimental choroidal neovascularization.International journal of ophthalmology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Cesar H CominDepartment of Computer Science, Federal University of São Carlos, São Carlos, SP, Brazil.
Demetrios I TsirukisDepartment of Ophthalmology, Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA, 02115, USA.
Ye SunDepartment of Ophthalmology, Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA, 02115, USA. ye.sun@childrens.harvard.edu.
Xiaoyin XuDepartment of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. xxu@bwh.harvard.edu.

Funding

Computer aided diagnosis of cancer metastases in the brainR01LM012434 · NLM · BRIGHAM AND WOMEN'S HOSPITAL · PI YOUNG, GEOFFREY · 2016 to 2020
$2.9M
Photoreceptor Determination of Retinal Blood Vessel Growth in RetinopathyR01EY029238 · NEI · BOSTON CHILDREN'S HOSPITAL · PI YE SUN · 2019 to 2026
$2.6M
The Mechanism of Immune-Vascular Crosstalk in RetinopathyR01EY030140 · NEI · BOSTON CHILDREN'S HOSPITAL · PI SUN, YE · 2019 to 2023
$2.0M
A novel informatics approach to understanding complex muscle fiber phenotypesR01LM011415 · NLM · BRIGHAM AND WOMEN'S HOSPITAL · PI XU, XIAOYIN · 2014 to 2017
$1.5M
NEI NIH HHS R01 EY029238NEI NIH HHS R01 EY030140NLM NIH HHS R01 LM011415NLM NIH HHS R01 LM012434
6 · The paper itself

Abstract

Blood leakage from the vessels in the eye is the hallmark of many vascular eye diseases. One of the preclinical mouse models of retinal blood leakage, the very-low-density-lipoprotein receptor deficient mouse (Vldlr

Indexed as

Fluorescein AngiographyTomography, Optical CoherenceAlgorithmsAnimalsDisease Models, AnimalHumansImage Processing, Computer-AssistedMiceMice, KnockoutRetinal NeovascularizationRetinal Vessels

Identifiers

PMID34615975
PMCPMC8494755

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.