ArticleScientific reports2021
Pulse sharpness as a quantitative index of vascular aging.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 5 citations in OpenAlex.
- First-harmonic attenuation of radial pulse waves as a sensitive marker for vascular aging.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Protocol for a Radial Pulse-Based Vascular Age Index Integrated with Traditional Korean Medicine Pulse Diagnosis.Journal of pharmacopuncture · 2026Article
- Multimodal deep learning for cardiovascular disease detection using pulse wave and vocal signals: a prediction model development and validation study.BMC medical informatics and decision making · 2026Article
- Functional MRI signatures of autonomic physiology in aging.Communications biology · 2025Article
- Functional MRI Signatures of Autonomic Physiology in Aging.bioRxiv : the preprint server for biology · 2025Article
- Review
- Diagnosis of kidney insufficiency by using the pressure waveforms of wrist-type sphygmomanometers: toward a convenient point-of-care device.American journal of translational research · 2023Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to develop a robust algorithm to quantify pulse sharpness that can complement the limitations of radial augmentation index (rAIx) and explore the role of this quantitative sharpness index in reflecting vascular aging or arterial stiffness. The pulse sharpness index (PSI) was developed by combining the end point angle and virtual height, and 528 radial pulses were analyzed. The PSI could be uniformly applied to various waveform morphologies, even those with no or vague tidal waves, unlike the rAIx. Significant sex differences were identified in the rAIx and PSI (P < 0.01 for both), and significant age-dependent decreases in the PSI were observed (P < 0.01). In addition, the PSI and age were correlated (r = - 0.550) at least as strong as the rAIx and age (r = 0.532), and the PSI had a significant negative correlation with arterial stiffness (r = - 0.700). Furthermore, the multiple linear regression model for arterial stiffness using the PSI, age, sex and heart rate showed the excellent performance (cross-validated R
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