Evidence map›Paper›PMID 34615876›Full record

ArticleNature communications2021

Multi-targeted

Ulrich Flögel, Sebastian Temme, Christoph Jacoby, Thomas Oerther, Petra Keul, Vera Flocke, Xiaowei Wang, Florian Bönner, Fabian Nienhaus, Karlheinz Peter and 4 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
7.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 76 citations in OpenAlex.

  1. Bypassing Heteronuclear MRI: Metal-Free Organosilicon Nanotracers for Background-Free HotspotAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  2. Kupffer Cell Capture-Evading Modifiable Sub-20 nm Lipid Nanodisc-BasedJournal of the American Chemical Society · 2026
    Article
  3. Article
  4. Article
  5. 7TMagnetic resonance in medicine · 2026
    Article
  6. MnChemistry (Weinheim an der Bergstrasse, Germany) · 2025
    Article
  7. Article
  8. Imaging of Thromboinflammation by MultispectralInternational journal of molecular sciences · 2025
    Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Quantitative in Vivo Molecular MRI.Advanced materials (Deerfield Beach, Fla.) · 2024
    Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. Quantitative assessment of angioplasty-induced vascular inflammation withJournal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2023
    Article
  19. Real-timeCommunications chemistry · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Ulrich FlögelExperimental Cardiovascular Imaging, Institute for Molecular Cardiology, Heinrich Heine University, Düsseldorf, Germany. floegel@uni-duesseldorf.de.ORCID 0000-0001-7181-4392
Sebastian TemmeExperimental Cardiovascular Imaging, Institute for Molecular Cardiology, Heinrich Heine University, Düsseldorf, Germany.ORCID 0000-0002-8807-2767
Christoph JacobyExperimental Cardiovascular Imaging, Institute for Molecular Cardiology, Heinrich Heine University, Düsseldorf, Germany.
Thomas OertherBruker BioSpin, Rheinstetten, Germany.
Petra KeulInstitute of Molecular Medicine III, Heinrich Heine University, Düsseldorf, Germany.
Vera FlockeExperimental Cardiovascular Imaging, Institute for Molecular Cardiology, Heinrich Heine University, Düsseldorf, Germany.
Xiaowei WangBaker Heart and Diabetes Institute, Melbourne, Australia.ORCID 0000-0001-8658-7399
Florian BönnerDepartment of Cardiology, Pneumology and Angiology, University Hospital Düsseldorf, Düsseldorf, Germany.
Fabian NienhausDepartment of Cardiology, Pneumology and Angiology, University Hospital Düsseldorf, Düsseldorf, Germany.
Karlheinz PeterBaker Heart and Diabetes Institute, Melbourne, Australia.
Jürgen SchraderCardiovascular Research Institute Düsseldorf (CARID), Heinrich Heine University, Düsseldorf, Germany.
Maria GrandochDepartment of Pharmacology and Clinical Pharmacology, Heinrich Heine University, Düsseldorf, Germany.
Malte KelmCardiovascular Research Institute Düsseldorf (CARID), Heinrich Heine University, Düsseldorf, Germany.
Bodo LevkauInstitute of Molecular Medicine III, Heinrich Heine University, Düsseldorf, Germany.
Düsseldorf University Hospital · DEHeinrich Heine University Düsseldorf · DEBaker Heart and Diabetes Institute · AUBruker (Germany) · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prediction of the transition from stable to acute coronary syndromes driven by vascular inflammation, thrombosis with subsequent microembolization, and vessel occlusion leading to irreversible myocardial damage is still an unsolved problem. Here, we introduce a multi-targeted and multi-color nanotracer platform technology that simultaneously visualizes evolving danger patterns in the development of progressive coronary inflammation and atherothrombosis prior to spontaneous myocardial infarction in mice. Individual ligand-equipped perfluorocarbon nanoemulsions are used as targeting agents and are differentiated by their specific spectral signatures via implementation of multi chemical shift selective

Indexed as

AnimalsCardiovascular DiseasesEarly DiagnosisFemaleHeartHeart FailureInflammationMagnetic Resonance ImagingMaleMiceMyocardial InfarctionMyocardiumNanoparticles

Identifiers

PMID34615876
PMCPMC8494909
OpenAlexW3203347449

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.