Evidence map›Paper›PMID 34615868›Full record

ArticleNature communications2021

A bioinspired scaffold for rapid oxygenation of cell encapsulation systems.

Long-Hai Wang, Alexander Ulrich Ernst, Duo An, Ashim Kumar Datta, Boris Epel, Mrignayani Kotecha, Minglin Ma

Abstract read
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed.

  1. Article
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  9. Article
  10. Accelerated EPR imaging using deep learning denoising.Magnetic resonance in medicine · 2025
    Article
  11. Article
  12. Oxygen dynamics and delivery strategies to enhance beta cell replacement therapy.American journal of physiology. Cell physiology · 2025
    Review
  13. Article
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  15. Article
  16. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Long-Hai WangBiological and Environmental Engineering, Cornell University, Ithaca, NY, USA.
Alexander Ulrich ErnstBiological and Environmental Engineering, Cornell University, Ithaca, NY, USA.ORCID 0000-0001-6209-8486
Duo AnBiological and Environmental Engineering, Cornell University, Ithaca, NY, USA.ORCID 0000-0002-7490-7022
Ashim Kumar DattaBiological and Environmental Engineering, Cornell University, Ithaca, NY, USA.
Boris EpelDepartment of Radiation and Cellular Oncology, The University of Chicago, Chicago, IL, USA.
Mrignayani KotechaO2M Technologies, LLC, Chicago, IL, USA.
Minglin MaBiological and Environmental Engineering, Cornell University, Ithaca, NY, USA. mm826@cornell.edu.ORCID 0000-0002-9553-7526

Funding

Preclinical Oxygen Imager to Model Efficient Cancer TreatmentR44CA224840 · NCI · O2M TECHNOLOGIES, LLC · PI KOTECHA, MRIGNAYANI · 2019 to 2020
$2.3M
Engineering an Islet Thread from zwitterionically modified alginates for type 1 diabetesR01DK105967 · NIDDK · CORNELL UNIVERSITY · PI MA, MINGLIN · 2018 to 2022
$1.9M
Acquisition of a Nano Computed Tomography Instrument for shared Cornell Imaging fS10OD012287 · OD · CORNELL UNIVERSITY · PI HERNANDEZ, CHRISTOPHER JOHN · 2013 to 2013
$755k
Robust Small Animal Oxygen Imager to Model Enhanced Cancer TreatmentR43CA224840 · NCI · O2M TECHNOLOGIES, LLC · PI EPEL, BORIS, KOTECHA, MRIGNAYANI · 2018 to 2018
$358k
NCI NIH HHS R43 CA224840NCI NIH HHS R44 CA224840NIDDK NIH HHS R01 DK105967NIH HHS S10 OD012287
6 · The paper itself

Abstract

Inadequate oxygenation is a major challenge in cell encapsulation, a therapy which holds potential to treat many diseases including type I diabetes. In such systems, cellular oxygen (O

Indexed as

AnimalsBiomimeticsCell EncapsulationCells, CulturedCell SurvivalElectron Spin Resonance SpectroscopyHumansHydrogelsMaleMiceMice, Inbred C57BLOxygenRatsRats, Sprague-DawleyHydrogelsOxygen

Identifiers

PMID34615868
PMCPMC8494927

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.