Evidence map›Paper›PMID 34615820›Full record

ArticleInternal medicine (Tokyo, Japan)2022

Complete Response Induced by Concurrent Chemoradiotherapy in a Patient with NUT Carcinoma.

Joji Muramatsu, Kohichi Takada, Shintaro Sugita, Takaaki Tsuchiya, Keisuke Yamamoto, Masaru Takagi, Kazuyuki Murase, Saki Ameda, Yohei Arihara, Koji Miyanishi and 2 more

Open access · diamondAbstract readCase Reports
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Therapeutic approaches to sinonasal NUT carcinoma: a systematic review.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Joji MuramatsuDepartment of Medical Oncology, Sapporo Medical University School of Medicine, Japan.
Kohichi TakadaDepartment of Medical Oncology, Sapporo Medical University School of Medicine, Japan.
Shintaro SugitaDepartment of Surgical Pathology, Sapporo Medical University School of Medicine, Japan.
Takaaki TsuchiyaDepartment of Radiology, Sapporo Medical University School of Medicine, Japan.
Keisuke YamamotoDepartment of Otolaryngology, Sapporo Medical University School of Medicine, Japan.
Masaru TakagiProton Therapy Center, Sapporo Teishinkai Hospital, Japan.
Kazuyuki MuraseDepartment of Medical Oncology, Sapporo Medical University School of Medicine, Japan.
Saki AmedaDepartment of Medical Oncology, Sapporo Medical University School of Medicine, Japan.
Yohei AriharaDepartment of Medical Oncology, Sapporo Medical University School of Medicine, Japan.
Koji MiyanishiDepartment of Medical Oncology, Sapporo Medical University School of Medicine, Japan.
Koh-Ichi SakataDepartment of Radiology, Sapporo Medical University School of Medicine, Japan.
Junji KatoDepartment of Medical Oncology, Sapporo Medical University School of Medicine, Japan.
Sapporo Medical University · JPToujinkai Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An 18-year-old man presented with sudden vision loss in his left eye. Magnetic resonance imaging revealed a tumor that had invaded the left optic nerve, originating from the left posterior ethmoid sinus. Immunohistochemical analyses identified positive staining for NUT protein in the nuclei of tumor cells. We diagnosed locally advanced NUT carcinoma (NC) and initiated concurrent chemoradiotherapy (CCRT), consisting of chemotherapy with vincristine, doxorubicin, and cyclophosphamide, alternating with ifosphamide and etoposide, plus radiation therapy. The patient achieved a complete response. CCRT can be a useful treatment option for adolescent and young-adult patients with locally advanced unresectable NC.

Indexed as

CarcinomaNasopharyngeal NeoplasmsAdolescentAdultAntineoplastic Combined Chemotherapy ProtocolsChemoradiotherapyHumansIfosfamideMaleVincristineIfosfamideVincristineconcurrent chemoradiotherapyNUT carcinomaVDC-IE regimen

Identifiers

PMID34615820
PMCPMC9107965
OpenAlexW3167653820

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.