Evidence map›Paper›PMID 34615818›Full record

ArticleInternal medicine (Tokyo, Japan)2022

Atypical Cogan's Syndrome Mimicking Giant Cell Arteritis Successfully Treated with Early Administration of Tocilizumab.

Kazusato Hara, Masataka Umeda, Keiko Segawa, Midori Akagi, Yushiro Endo, Tomohiro Koga, Shin-Ya Kawashiri, Kunihiro Ichinose, Hideki Nakamura, Takahiro Maeda and 1 more

Open access · diamondAbstract readCase Reports
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Kazusato HaraDepartment of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Japan.
Masataka UmedaDepartment of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Japan.
Keiko SegawaDepartment of Radiological Sciences, Nagasaki University Graduate School of Biomedical Sciences, Japan.
Midori AkagiDepartment of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Japan.
Yushiro EndoDepartment of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Japan.
Tomohiro KogaDepartment of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Japan.
Shin-Ya KawashiriDepartment of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Japan.
Kunihiro IchinoseDepartment of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Japan.
Hideki NakamuraDepartment of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Japan.
Takahiro MaedaDepartment of General Medicine, Nagasaki University Graduate School of Biomedical Sciences, Japan.
Atsushi KawakamiDepartment of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Japan.
Nagasaki University · JPNagasaki University Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 49-year-old Japanese man with a 2-month history of a fever, headache, and bilateral conjunctival hyperemia was admitted. His condition fulfilled the giant cell arteritis classification criteria (new headache, temporal artery tenderness, elevated ESR) and atypical Cogan's syndrome (CS) with scleritis and sensorineural hearing loss (SNHL). The interleukin (IL)-6 serum level was extremely high. Two weeks after his insufficient response of SNHL and scleritis to oral prednisolone, we administered tocilizumab (TCZ); rapid improvements in scleritis and SNHL occurred. Early IL-6 target therapy can help prevent irreversible CS-induced sensory organ damage.

Indexed as

Cogan SyndromeGiant Cell ArteritisHearing Loss, SensorineuralKeratitisScleritisAntibodies, Monoclonal, HumanizedApraxiasHeadacheHumansMaleMiddle AgedAntibodies, Monoclonal, HumanizedtocilizumabCogan's syndromegiant cell arteritisinterleukin-6tocilizumab

Identifiers

PMID34615818
PMCPMC9107983
OpenAlexW3202127078

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.