Evidence map›Paper›PMID 34615540›Full record

ArticleMolecular autism2021

Affect and gaze responses during an Emotion-Evoking Task in infants at an increased likelihood for autism spectrum disorder.

Lori-Ann R Sacrey, Lonnie Zwaigenbaum, Jessica A Brian, Isabel M Smith, Vickie Armstrong, Sarah Raza, Tracy Vaillancourt, Louis A Schmidt

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular autism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Lori-Ann R SacreyDepartment of Pediatrics, Autism Research Centre - E209, Glenrose Rehabilitation Hospital, University of Alberta, 10230-111 Avenue, Edmonton, AB, T5G 0B7, Canada. sacrey@ualberta.ca.ORCID 0000-0002-4229-6933
Lonnie ZwaigenbaumDepartment of Pediatrics, Autism Research Centre - E209, Glenrose Rehabilitation Hospital, University of Alberta, 10230-111 Avenue, Edmonton, AB, T5G 0B7, Canada.
Jessica A BrianBloorview Research Institute, University of Toronto, Toronto, ON, Canada.
Isabel M SmithIWK Health Centre, Dalhousie University, Halifax, NS, Canada.
Vickie ArmstrongIWK Health Centre, Dalhousie University, Halifax, NS, Canada.
Sarah RazaDepartment of Pediatrics, Autism Research Centre - E209, Glenrose Rehabilitation Hospital, University of Alberta, 10230-111 Avenue, Edmonton, AB, T5G 0B7, Canada.
Tracy VaillancourtUniversity of Ottawa, Ottawa, ON, Canada.
Louis A SchmidtMcMaster University, Hamilton, ON, Canada.
University of Alberta · CADalhousie University · CAMcMaster University · CAUniversity of Ottawa · CAUniversity of Toronto · CA

Funding

CIHR
6 · The paper itself

Abstract

backgroundThe majority of research examining emotional difficulties in autism spectrum disorder (ASD) prior to age 2 relies on parent report.

methodsWe examined behavioral responses (affect and gaze) during emotionally salient tasks designed to elicit mildly positive and negative emotional states in infants. At 12 and 18 months, infants at an increased likelihood for an ASD diagnosis (IL; have an older sibling with ASD; n = 60) and low likelihood (LL; no family history of ASD; n = 21) completed the Emotion-Evoking (EE) Task and parents completed the Infant Behavior Questionnaire-Revised (IBQ-R). All children received an Autism Diagnostic Observation Scale-second Edition assessment for ASD symptomatology at 24 months.

resultsThe main findings were (1) the IL group displayed higher rates of negative affect and spent less time looking at the task objects compared to the LL group, and (2) affect and gaze scores at 12 and 18 months, but not scores on the IBQ-R, predicted ASD symptoms at 24 months. LIMITATIONS: The data were drawn from an IL sample and may not be generalizable to the general ASD population, and the children were not followed to determine a diagnosis of ASD.

conclusionThese results suggest that behavioral responses can provide important information that complements parent reports of emotional regulation in IL infants as early as 12 months of age.

Indexed as

Autism Spectrum DisorderChildChild, PreschoolEmotionsHumansInfantInfant BehaviorSiblingsSurveys and QuestionnairesAffectAutism*Emotion regulationGazeIncreased likelihood cohortTemperament

Identifiers

PMID34615540
PMCPMC8493694
OpenAlexW3203422045

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.