Evidence map›Paper›PMID 34615529›Full record

ArticleReproductive biology and endocrinology : RB&E2021

The effect of short term exposure to outdoor air pollution on fertility.

Mireia González-Comadran, Bénédicte Jacquemin, Marta Cirach, Rafael Lafuente, Thomas Cole-Hunter, Mark Nieuwenhuijsen, Mario Brassesco, Buenaventura Coroleu, Miguel Angel Checa

Open access · goldAbstract read
In one paragraph

Article in Reproductive biology and endocrinology : RB&E, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Observed Effects on Very Early Pregnancy Linked to Ambient PMEnvironment & health (Washington, D.C.) · 2024
    Article
  8. Article
  9. Review
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 3 countries.

Mireia González-ComadranDepartment of Obstetrics and Gynecology, Hospital del Mar, Barcelona, Spain.
Bénédicte JacqueminUniv Rennes 1, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S 1085, F-35000, Rennes, France.
Marta CirachInstitute for Global Health (ISGlobal), Barcelona, Spain.
Rafael LafuenteCentro de Infertilidad y Reproducción Humana (CIRH), Barcelona, Spain.
Thomas Cole-HunterInstitute for Global Health (ISGlobal), Barcelona, Spain.
Mark NieuwenhuijsenInstitute for Global Health (ISGlobal), Barcelona, Spain.
Mario BrassescoCentro de Infertilidad y Reproducción Humana (CIRH), Barcelona, Spain.
Buenaventura CoroleuHospital Universitari Quiron Dexeus, Salud de la Mujer Dexeus, Barcelona, Spain.
Miguel Angel ChecaDepartment of Obstetrics and Gynecology, Hospital del Mar, Barcelona, Spain. macheca@hospitaldelmar.cat.
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública · ESCentro de Infertilidad y Reproducción Humana · ESHospital Del Mar · ESHospital del Mar Research Institute · ESHospital Universitario Dexeus · ESPompeu Fabra University · ES

Funding

agència de gestió d'ajuts universitaris i de recerca SGB 2017-2019instituto de salud carlos iii PI13/00454
6 · The paper itself

Abstract

backgroundThere is evidence to suggest that long term exposure to air pollution could be associated with decreased levels of fertility, although there is controversy as to how short term exposure may compromise fertility in IVF patients and what windows of exposure during the IVF process patients could be most vulnerable.

methodsThis prospective cohort study aimed to evaluate the impact of acute exposure that air pollution have on reproductive outcomes in different moments of the IVF process. Women undergoing IVF living in Barcelona were recruited. Individual air pollution exposures were modelled at their home address 15 and 3 days before embryo transfer (15D and 3D, respectively), the same day of transfer (D0), and 7 days after (D7). The pollutants modelled were: PM

resultsOne hundred ninety-four women were recruited, contributing with data for 486 embryo transfers. Acute and subacute exposure to PMs showed a tendency in increasing miscarriage rate and reducing clinical pregnancy rate, although results were not statistically significant. The first sensitivity analysis, showed a significant risk of miscarriage for PM

conclusionsExposure to particulate matter has a negative impact on reproductive outcomes in IVF patients. Subacute exposure seems to increase the harmful effect of the acute exposure on miscarriage and pregnancy rates. Nitrogen dioxides do not modify significantly the reproductive success.

Indexed as

Air PollutionFertilityPregnancy OutcomeAbortion, SpontaneousAdultAir PollutantsCohort StudiesEnvironmental ExposureFemaleFertilization in VitroHumansInfertility, FemaleParticulate MatterPregnancyRisk FactorsSpainAir PollutantsParticulate MatterAcute exposureFertilityMiscarriageNitrogen dioxideNO2Particulate matterPM10PM2.5Pregnancy

Identifiers

PMID34615529
PMCPMC8493680
OpenAlexW3203616016

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.