ArticleBMC developmental biology2021
Msx1 haploinsufficiency modifies the Pax9-deficient cardiovascular phenotype.
Article in BMC developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 10 citations in OpenAlex.
- The Role of Four New Biochemical Markers in the Diagnosis and Prognosis of Ovarian Carcinoma.Reproductive sciences (Thousand Oaks, Calif.) · 2026Article
- Atrial Septal Defect (ASD) associated long non-coding RNAGenes & diseases · 2023Article
- Quantitative Image Processing for Three-Dimensional Episcopic Images of Biological Structures: Current State and Future Directions.Biomedicines · 2023Review
- Novel PAX9 compound heterozygous variants in a Chinese family with non-syndromic oligodontia and genotype-phenotype analysis of PAX9 variants.Journal of applied oral science : revista FOB · 2023Article
- Morphogenetic processes in the development and evolution of the arteries of the pharyngeal arches: their relations to congenital cardiovascular malformations.Frontiers in cell and developmental biology · 2023Review
- PAX Genes in Cardiovascular Development.International journal of molecular sciences · 2022Review
- PAX9 in Cancer Development.International journal of molecular sciences · 2022Review
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Authors and funding
11 authors at 6 institutions in 3 countries.
Funding
Abstract
backgroundSuccessful embryogenesis relies on the coordinated interaction between genes and tissues. The transcription factors Pax9 and Msx1 genetically interact during mouse craniofacial morphogenesis, and mice deficient for either gene display abnormal tooth and palate development. Pax9 is expressed specifically in the pharyngeal endoderm at mid-embryogenesis, and mice deficient for Pax9 on a C57Bl/6 genetic background also have cardiovascular defects affecting the outflow tract and aortic arch arteries giving double-outlet right ventricle, absent common carotid arteries and interruption of the aortic arch.
resultsIn this study we have investigated both the effect of a different genetic background and Msx1 haploinsufficiency on the presentation of the Pax9-deficient cardiovascular phenotype. Compared to mice on a C57Bl/6 background, congenic CD1-Pax9
conclusionsMsx1 haploinsufficiency mitigates the arch artery defects in Pax9
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