Evidence map›Paper›PMID 34615371›Full record

ReviewArteriosclerosis, thrombosis, and vascular biology2021

Platelet Heterogeneity in Myeloproliferative Neoplasms.

Sally Thomas, Anandi Krishnan

Abstract readReview
In one paragraph

Review in Arteriosclerosis, thrombosis, and vascular biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Heterogeneity of platelets and their responses.Research and practice in thrombosis and haemostasis · 2024
    Article
  8. Review
  9. The Combination ofCancer control : journal of the Moffitt Cancer Center
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Sally ThomasDepartment of Oncology and Metabolism, University of Sheffield and Department of Haematology, Royal Hallamshire Hospital, United Kingdom (S.T.).ORCID 0000-0002-0027-0815
Anandi KrishnanDepartment of Pathology, Stanford University School of Medicine, CA (A.K.).ORCID 0000-0002-0962-2215

Funding

Stanford Center for Clinical & Translational Education and Research (Spectrum)UL1TR003142 · NCATS · STANFORD UNIVERSITY · PI O'HARA, RUTH M · 2019 to 2023
$45.0M
Spectrum Stanford Center for clinical and Translational Research and EducationUL1TR001085 · NCATS · STANFORD UNIVERSITY · PI CULLEN, MARK RICHARD, GREENBERG, HARRY BERNARD · 2013 to 2017
$37.1M
Integrated Clinical and Transcriptomic Profiling to Characterize Disease PhenotypeK08HG010061 · NHGRI · STANFORD UNIVERSITY · PI KRISHNAN, ANANDI · 2018 to 2022
$955k
Object Storage for Secure Data SharingS10OD025082 · OD · STANFORD UNIVERSITY · PI DATTA, SOMALEE · 2018 to 2018
$593k
NCATS NIH HHS UL1 TR001085NCATS NIH HHS UL1 TR003142NHGRI NIH HHS K08 HG010061NIH HHS S10 OD025082
6 · The paper itself

Abstract

Myeloproliferative neoplasms (MPNs) are a group of malignant disorders of the bone marrow where a dysregulated balance between proliferation and differentiation gives rise to abnormal numbers of mature blood cells. MPNs encompass a spectrum of disease entities with progressively more severe clinical features, including complications with thrombosis and hemostasis and an increased propensity for transformation to acute myeloid leukemia. There is an unmet clinical need for markers of disease progression. Our understanding of the precise mechanisms that influence pathogenesis and disease progression has been limited by access to disease-specific cells as biosources. Here, we review the landscape of MPN pathology and present blood platelets as potential candidates for disease-specific understanding. We conclude with our recent work discovering progressive platelet heterogeneity by subtype in a large clinical cohort of patients with MPN.

Indexed as

Platelet ActivationThrombopoiesisAnimalsAntineoplastic AgentsBlood CoagulationBlood PlateletsHumansMolecular Targeted TherapyMyeloproliferative DisordersPhenotypePlatelet Aggregation InhibitorsAntineoplastic AgentsPlatelet Aggregation Inhibitorsblood plateletsbone marrowhemostasismyelofibrosispolycythemia verathrombosistranscriptome

Identifiers

PMID34615371
PMCPMC8551046

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.