ArticleCirculation research2021
SMC-Derived Hyaluronan Modulates Vascular SMC Phenotype in Murine Atherosclerosis.
Open access · greenAbstract read
In one paragraph
Article in Circulation research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 14% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Candidate Biomarkers Linking Periodontitis with Atherosclerotic and Related Cardiovascular Phenotypes: A Systematic Review Focused on Sex-Specific Evidence.International journal of molecular sciences · 2026Pooled it
- Hyaluronan Regulates Vascular Smooth Muscle Cell Osteogenic Differentiation and Vascular Calcification.Biomolecules · 2026Article
- Semaglutide reduces murine blood pressure through the vascular smooth muscle GLP-1 receptor.JCI insight · 2026Article
- Atherosclerotic plaque-derived extracellular vesicles mediate smooth muscle cell phenotypic switching and promote vascular remodeling : EVs promote VSMC phenotypic switching.Cellular and molecular life sciences : CMLS · 2026Article
- Pathology-tailored nanotherapy via Galectin-3-targeted and triple-responsive nanoparticles enables multimodal therapy against aortic dissection.Journal of nanobiotechnology · 2026Article
- Reprogramming Atherosclerosis: Precision Drug Delivery, Nanomedicine, and Immune-Targeted Therapies for Cardiovascular Risk Reduction.Pharmaceutics · 2025Review
- Smooth Muscle Cell-Derived Fibronectin Promotes an Atheroprotective Smooth Muscle Cell Phenotype Associated With Altered NO-cGMP Signaling.Journal of the American Heart Association · 2025Article
- Targeted drug delivery systems for atherosclerosis.Journal of nanobiotechnology · 2025Review
- Olsenella scatoligenes-derived skatole promotes smooth muscle cell proliferation and migration to aggravate atherosclerosis.The ISME journal · 2025Article
- Hyaluronan synthase 3 deficiency lowers the incidence of ruptures of abdominal aortic aneurysms by reducing monocyte infiltration.Frontiers in immunology · 2025Article
- Inhibition of Abdominal Aortic Aneurysm Progression Through the CXCL12/CXCR4 Axis via MiR206-3p Sponge.Journal of cellular and molecular medicine · 2025Article
- Big data analytics and scRNA-seq in human aortic aneurysms and dissections: role of endothelial MerTK.Theranostics · 2025Article
- Review
- Hormonal influence: unraveling the impact of sex hormones on vascular smooth muscle cells.Biological research · 2024Review
- Understanding Galectin-3's Role in Diastolic Dysfunction: A Contemporary Perspective.Life (Basel, Switzerland) · 2024Review
- Phenotypic Switching of Vascular Smooth Muscle Cells in Atherosclerosis.Journal of the American Heart Association · 2023Review
- Proteomic Atlas of Atherosclerosis: The Contribution of Proteoglycans to Sex Differences, Plaque Phenotypes, and Outcomes.Circulation research · 2023Article
- Identification of a novel role for TL1A/DR3 deficiency in acute respiratory distress syndrome that exacerbates alveolar epithelial disruption.Respiratory research · 2023Article
- Clinical Potential of Hydrogen Sulfide in Peripheral Arterial Disease.International journal of molecular sciences · 2023Review
- A New AutosomalArteriosclerosis, thrombosis, and vascular biology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 4 institutions in 3 countries.
Felicia Hartmann *Institute of Pharmacology and Clinical Pharmacology, Medical Faculty, Heinrich-Heine-University Düsseldorf, Germany (F.H., D.J.G., S.H., A.P., J.W.F.).ORCID 0000-0001-7691-0201
Daniel J Gorski *Institute of Pharmacology and Clinical Pharmacology, Medical Faculty, Heinrich-Heine-University Düsseldorf, Germany (F.H., D.J.G., S.H., A.P., J.W.F.).ORCID 0000-0001-9734-7008
Alexandra A C NewmanRobert M. Berne Cardiovascular Research Center (A.A.C.N., K.M.O., V.S., R.A.D., G.K.O), University of Virginia-School of Medicine, Charlottesville.ORCID 0000-0001-8938-2428
Susanne HomannInstitute of Pharmacology and Clinical Pharmacology, Medical Faculty, Heinrich-Heine-University Düsseldorf, Germany (F.H., D.J.G., S.H., A.P., J.W.F.).
Anne PetzInstitute of Pharmacology and Clinical Pharmacology, Medical Faculty, Heinrich-Heine-University Düsseldorf, Germany (F.H., D.J.G., S.H., A.P., J.W.F.).
Katherine M OwsianyRobert M. Berne Cardiovascular Research Center (A.A.C.N., K.M.O., V.S., R.A.D., G.K.O), University of Virginia-School of Medicine, Charlottesville.
Vlad SerbuleaRobert M. Berne Cardiovascular Research Center (A.A.C.N., K.M.O., V.S., R.A.D., G.K.O), University of Virginia-School of Medicine, Charlottesville.
Yu-Qing ZhouDepartment of Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada (Y.Q.-Z., M.B.).
Rebecca A DeatonRobert M. Berne Cardiovascular Research Center (A.A.C.N., K.M.O., V.S., R.A.D., G.K.O), University of Virginia-School of Medicine, Charlottesville.ORCID 0000-0001-7569-1924
Michelle BendeckDepartment of Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada (Y.Q.-Z., M.B.).ORCID 0000-0002-9140-8508
Gary K Owens *Robert M. Berne Cardiovascular Research Center (A.A.C.N., K.M.O., V.S., R.A.D., G.K.O), University of Virginia-School of Medicine, Charlottesville.ORCID 0000-0002-7119-9657
Jens W Fischer *Institute of Pharmacology and Clinical Pharmacology, Medical Faculty, Heinrich-Heine-University Düsseldorf, Germany (F.H., D.J.G., S.H., A.P., J.W.F.).ORCID 0000-0002-3625-1624
Heinrich Heine University Düsseldorf · DEUniversity of Virginia · USUniversity of Toronto · CAAnna Needs Neuroblastoma Answers · US
Funding
BASIC CARDIOVASCULAR RESEARCH TRAINING GRANTT32HL007284 · NHLBI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Brant E Isakson, Gary K Owens · 1985 to 2026
$19.6MCancer Research Training Program: From Molecular Mechanisms to Therapeutic StrategiesT32CA009109 · NCI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Andrew Carl Dudley, Melanie R Rutkowski · 1985 to 2026
$13.9MTraining Program in Cardiovascular SciencesT32HL098129 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Glenn I Fishman, Ira J Goldberg · 2009 to 2026
$5.9MIL1beta signaling in SMCpromotes beneficial changes in late stage atherosclerotic lesion pathogenesisR01HL141425 · NHLBI · UNIVERSITY OF VIRGINIA · PI OWENS, GARY K · 2019 to 2022
$3.1MDefining SMC phenotypes critical in late stage atherosclerosis pathogenesisR01HL136314 · NHLBI · UNIVERSITY OF VIRGINIA · PI OWENS, GARY K · 2018 to 2021
$3.0MRole of Metabolic Reprogramming in Formation and Maintenance of the Acta2+ Atherosclerotic Lesion Protective Fibrous CapR01HL155165 · NHLBI · UNIVERSITY OF VIRGINIA · PI OWENS, GARY K · 2021 to 2024
$2.9MPDGFbeta Receptor Activation Promotes Atheroprotective Changes in SMC PhenotypeR01HL132904 · NHLBI · UNIVERSITY OF VIRGINIA · PI OWENS, GARY K · 2017 to 2020
$2.6MNCI NIH HHS T32 CA009109NHLBI NIH HHS R01 HL132904NHLBI NIH HHS R01 HL136314NHLBI NIH HHS R01 HL141425NHLBI NIH HHS R01 HL155165NHLBI NIH HHS T32 HL007284NHLBI NIH HHS T32 HL098129
Abstract
[Figure: see text].
Indexed as
ActinsAnimalsCollagenGalectin 3Gene DeletionHyaluronan ReceptorsHyaluronan SynthasesHyaluronic AcidMiceMice, Inbred C57BLMuscle, Smooth, VascularMyocytes, Smooth MusclePhenotypePlaque, AtheroscleroticActa2 protein, mouseActinsCollagenGalectin 3Has3 protein, mouseHyaluronan ReceptorsHyaluronan SynthasesHyaluronic AcidLgals3 protein, mouseatherosclerosisextracellular matrixgalectin-3micephenotype
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.