Evidence map›Paper›PMID 34615350›Full record

ArticleEnvironmental science & technology2021

Biological Mitigation of Antibiotic Resistance Gene Dissemination by Antioxidant-Producing Microorganisms in Activated Sludge Systems.

Chong-Yang Ren, En-Ling Wu, Erica M Hartmann, He-Ping Zhao

Open access · greenAbstract read
In one paragraph

Article in Environmental science & technology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 61 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Chong-Yang RenMOE Key Lab of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Science, Zhejiang University, Hangzhou 310058, China.
En-Ling WuDivision of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, United States.
Erica M HartmannDepartment of Civil and Environmental Engineering, Northwestern University, Evanston, Illinois 60208, United States.ORCID 0000-0002-0966-2014
He-Ping ZhaoMOE Key Lab of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Science, Zhejiang University, Hangzhou 310058, China.ORCID 0000-0002-5177-8010
Northwestern University · USZhejiang University · CN

Funding

Technology CoreU19AI135964 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI JUSTIN B. STARREN · 2018 to 2026
$24.7M
Translational Research Training in Infectious DiseasesT32AI095207 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Claudia A Hawkins, Jennie H Kwon · 2012 to 2026
$2.2M
NIAID NIH HHS T32 AI095207NIAID NIH HHS U19 AI135964
6 · The paper itself

Abstract

Antibiotic resistance is the principal mechanism of an evergrowing bacterial threat. Antibiotic residues in the environment are a major contributor to the spread of antibiotic resistance genes (ARGs). Subinhibitory concentrations of antibiotics cause bacteria to produce reactive oxygen species (ROS), which can lead to mutagenesis and horizontal gene transfer (HGT) of ARGs; however, little is known about the mitigation of ARG dissemination through ROS removal by antioxidants. In this study, we examine how antioxidant-producing microorganisms inoculated in replicate activated sludge systems can biologically mitigate the dissemination of ARGs. Through quantitative polymerase chain reaction (qPCR), we showed that antioxidant-producing microorganisms could decrease the persistence of the RP4 plasmid and alleviate enrichment of ARGs (

Indexed as

Anti-Bacterial AgentsSewageAntioxidantsDrug Resistance, MicrobialGenes, BacterialAnti-Bacterial AgentsAntioxidantsSewageactivated sludgeantibiotic resistance genesantioxidant-producing microorganismdisseminationreactive oxygen species

Identifiers

PMID34615350
PMCPMC9529052
OpenAlexW3203249899

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.