ArticleProceedings of the National Academy of Sciences of the United States of America1986
Cellular localization of proenkephalin mRNA in rat brain: gene expression in the caudate-putamen and cerebellar cortex.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1986. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 70 citations in OpenAlex.
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- Delta Opioid Pharmacology in Relation to Alcohol Behaviors.Handbook of experimental pharmacology · 2018Review
- Pharmacological traits of delta opioid receptors: pitfalls or opportunities?Psychopharmacology · 2013Review
- Tag-mass: specific molecular imaging of transcriptome and proteome by mass spectrometry based on photocleavable tag.Journal of proteome research · 2007Article
- Presynaptic versus postsynaptic localization of mu and delta opioid receptors in dorsal and ventral striatopallidal pathways.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1997Article
- Cortically driven immediate-early gene expression reflects modular influence of sensorimotor cortex on identified striatal neurons in the squirrel monkey.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1997Article
- Cells expressing preproenkephalin mRNA in the rat pineal gland are not serotonin-producing pinealocytes: evidence using in situ hybridization combined with immunocytochemistry for serotonin.Cellular and molecular neurobiology · 1996Article
- Cellular localization of proenkephalin mRNA and enkephalin peptide products in cultured astrocytes.Brain research · 1990Article
- A neuropeptide precursor in cerebellum: proenkephalin exists in subpopulations of both neurons and astrocytes.The EMBO journal · 1990Article
- Localization of striatal opioid gene expression, and its modulation by the mesostriatal dopamine pathway: an in situ hybridization study.Journal of molecular neuroscience : MN · 1989Article
- Regulation of neuropeptide gene expression by steroid hormones.Molecular neurobiology · 1988Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cellular locations of proenkephalin mRNA have been determined for the caudate-putamen and cerebellar cortex of the rat brain by in situ hybridization. In the caudate-putamen, more than half of the neurons express the proenkephalin gene. Morphologically, they are medium-sized cells that may represent projection neurons. In the cerebellar cortex, proenkephalin mRNA is present in a subpopulation of neurons in the granule layer that appear to be Golgi cells--i.e., inhibitory interneurons. The presence of [Met]enkephalin, a pentapeptide derived from proenkephalin, in these two brain areas is consistent with a synthetic role for this mRNA and implicates proenkephalin gene expression in the control of motor function.
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