Evidence map›Paper›PMID 34614552›Full record

ArticleChronic obstructive pulmonary diseases (Miami, Fla.)2021

Increased Health Care Resource Utilization and Costs Associated with Herpes Zoster Among Patients Aged ≥50 Years with Chronic Obstructive Pulmonary Disease in the United States.

Parinaz Ghaswalla, Philippe Thompson-Leduc, Wendy Y Cheng, Colin Kunzweiler, Min-Jung Wang, Michael Bogart, Brandon J Patterson, Mei Sheng Duh, John Wojciehowski, Suna Park and 1 more

Open access · diamondAbstract read
In one paragraph

Article in Chronic obstructive pulmonary diseases (Miami, Fla.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 15 citations in OpenAlex.

  1. Global herpes zoster burden in adults with COPD: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Parinaz GhaswallaU.S. Health Outcomes and Epidemiology - Vaccines, GSK, Philadelphia, Pennsylvania, United States.
Philippe Thompson-LeducHealth Economics and Outcomes Research, Analysis Group, Inc., Montreal, Quebec, Canada.
Wendy Y ChengHealth Economics and Outcomes Research, Analysis Group, Inc., Boston, Massachusetts, United States.
Colin KunzweilerHealth Economics and Outcomes Research, Analysis Group, Inc., Boston, Massachusetts, United States.
Min-Jung WangHealth Economics and Outcomes Research, Analysis Group, Inc., Boston, Massachusetts, United States.
Michael BogartU.S. Medical Affairs, GSK, Research Triangle Park, North Carolina, United States.
Brandon J PattersonU.S. Health Outcomes and Epidemiology - Vaccines, GSK, Philadelphia, Pennsylvania, United States.
Mei Sheng DuhHealth Economics and Outcomes Research, Analysis Group, Inc., Boston, Massachusetts, United States.
John WojciehowskiHealth Economics and Outcomes Research, Analysis Group, Inc., Boston, Massachusetts, United States.
Suna ParkHealth Economics and Outcomes Research, Analysis Group, Inc., Boston, Massachusetts, United States.
Barbara P YawnDepartment of Family Medicine and Community Health, University of Minnesota, Minneapolis, Minnesota, United States.
Group for Research in Decision Analysis · CA

Funding

GlaxoSmithKline HO-19-19749/VxHO-000050
6 · The paper itself

Abstract

backgroundPatients with chronic obstructive pulmonary disease (COPD) are potentially at increased risk of herpes zoster (HZ). Little is known about the impact of an HZ episode on health care resource utilization (HRU) and costs among patients with COPD.

methodsThis retrospective cohort study of individuals aged ≥50 years in the United States (US) used administrative claims data from Optum's de-identified Clinformatics Data Mart Database for commercially insured and Medicare Advantage members (2013-2018). Two cohorts of patients with COPD, with HZ (COPD+/HZ+) and without HZ (COPD+/HZ-), were identified. All-cause and COPD-related HRU rates and costs (2018 US dollars) were compared between cohorts for up to 12 months of follow-up. Comparisons were controlled for baseline differences through propensity score adjustment.

resultsA total of 3415 COPD+/HZ+ and 35,360 COPD+/HZ- patients (mean ages 73.2 ± 9.0 and 72.4 ± 9.4 years, respectively) were identified. Patients in the COPD+/HZ+ versus COPD+/HZ- cohort had increased use of all-cause (adjusted incidence rate ratio [aIRR] 1.17; 95% confidence interval [CI] 1.14, 1.21) and COPD-related (aIRR 1.27; 95% CI 1.21, 1.34) medical services (both

conclusionsHRU and cost burden is higher in patients with COPD with vs without HZ. These results could help to estimate the potential cost benefits of HZ vaccination among patients with COPD.

Indexed as

chronic obstructive pulmonary diseaseCOPDhealthcare resource utilizationherpes zostershinglesvaccination

Identifiers

PMID34614552
PMCPMC8686847
OpenAlexW3203937897

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.