ArticleProceedings of the National Academy of Sciences of the United States of America1986
Characterization of a female-specific cDNA derived from a developmentally regulated mRNA in the human blood fluke Schistosoma mansoni.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1986. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 86 citations in OpenAlex.
- Rhodopsin orphan GPCR20 interacts with neuropeptides and directs growth, sexual differentiation, and egg production in femaleMicrobiology spectrum · 2024Article
- Epigenetic changes modulate schistosome egg formation and are a novel target for reducing transmission of schistosomiasis.PLoS pathogens · 2014Article
- Transcriptional analysis of a unique set of genes involved in Schistosoma mansoni female reproductive biology.PLoS neglected tropical diseases · 2012Article
- The embryonic development of Schistosoma mansoni eggs: proposal for a new staging system.Development genes and evolution · 2009Article
- Use of genomic DNA as an indirect reference for identifying gender-associated transcripts in morphologically identical, but chromosomally distinct, Schistosoma mansoni cercariae.PLoS neglected tropical diseases · 2008Article
- Schistosoma mansoni TGF-beta receptor II: role in host ligand-induced regulation of a schistosome target gene.PLoS pathogens · 2006Article
- Isolation of cDNAs encoding secreted and transmembrane proteins from Schistosoma mansoni by a signal sequence trap method.Infection and immunity · 2003Article
- Identification of Schistosoma mansoni gender-associated gene transcripts by cDNA microarray profiling.Genome biology · 2002Article
- Article
- Structure of synthetic peptide analogues of an eggshell protein of Schistosoma mansoni.Protein science : a publication of the Protein Society · 1993Article
- F10, the gene for the glycine-rich major eggshell protein of Schistosoma mansoni recognizes a family of hypervariable minisatellites in the human genome.Nucleic acids research · 1990Article
- Molecular characterization of SerH3, a Tetrahymena thermophila gene encoding a temperature-regulated surface antigen.Molecular and cellular biology · 1990Article
- Tandemly repeated exons encode 81-base repeats in multiple, developmentally regulated Schistosoma mansoni transcripts.Molecular and cellular biology · 1988Article
- Small gene family encoding an eggshell (chorion) protein of the human parasite Schistosoma mansoni.Molecular and cellular biology · 1988Article
- Isolation and characterization of expression cDNA clones encoding antigens of Onchocerca volvulus infective larvae.The Journal of clinical investigation · 1988Article
- Cloning and characterization of a female genital complex cDNA from the liver fluke Fasciola hepatica.Proceedings of the National Academy of Sciences of the United States of America · 1987Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
We have isolated and characterized a cDNA clone that is derived from a developmentally regulated mRNA found only in mature female schistosomes. The mRNA is approximately 950 nucleotides in length and is not detectable in immature female schistosomes isolated from single-sex infections, in male worms, or in eggs. During normal bisexual infections, the mRNA species is first detected 28 days after infection (the time of worm pairing) and increases to a high level 35 days after infection, coinciding with the start of egg production. The nucleotide sequence of the cDNA shows two large open reading frames in the coding strand. Several features of the clone, including the deduced sequence of the polypeptide encoded by one of the reading frames, suggest a relationship to the silk moth chorion (egg shell) gene family. The isolation of this clone provides us with a probe for further studies of female schistosome development and is a first step toward a detailed understanding of this process at the molecular level.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.