ArticleImmunity2021
Inhibition of the BTK-IDO-mTOR axis promotes differentiation of monocyte-lineage dendritic cells and enhances anti-tumor T cell immunity.
2 registry-linked trialsOpen access · bronzeAbstract read
In one paragraph
Article in Immunity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 55 papers.
0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed
4.0field-weighted citation impact, top 5% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Phase 2 Trial of Indoximod With Chemotherapy and Radiation for Children With Progressive Brain Tumors or Newly Diagnosed DIPG
Repurposing Ibrutinib for Chemo-Immunotherapy in a Phase 1b Study of Ibrutinib With Indoximod Plus Metronomic Cyclophosphamide and Etoposide for Pediatric Patients With Brain Cancer
Who cites it
55 citing papers in PubMed, 73 citations in OpenAlex.
- Trial
- Ecosystem-matched reprogramming of the tumor-immune microenvironment to overcome cancer immunotherapy resistance.Molecular cancer · 2026Review
- BTK inhibition enhances immunovirotherapy in glioblastoma via tertiary lymphoid structure modulation.bioRxiv : the preprint server for biology · 2026Article
- Prostaglandin D2 axis impairs immunity against melanoma via dendritic cells and γδ T cells in middle-aged mice.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- Tumor-activated dual metabolic nanomodulator turns over tolerogenic tumor control and unleashes systemic immune responses.Journal of nanobiotechnology · 2026Article
- PRMT3 Drives IDO1-Dependent Radioresistance and Immunosuppression by Promoting Kynurenine Metabolism in Non-Small Cell Lung Cancer.Cancer research · 2026Article
- The IDO1/AhR-HIF-1α metabolic axis: ARNT competition as a central antagonistic switch in autoimmune pathogenesis.Frontiers in immunology · 2026Review
- Research progress on resistance mechanisms to CAR-T cell therapy in diffuse large B-cell lymphoma.Frontiers in oncology · 2026Review
- Metabolites as agents and targets for cancer immunotherapy.Nature reviews. Drug discovery · 2025Review
- Therapeutic approaches for targeting the pediatric brain tumor microenvironment.Drug delivery and translational research · 2025Review
- Slc7a5 promotes T cell anti-tumor immunity through sustaining cytotoxic T lymphocyte effector function.Oncogene · 2025Article
- Dendritic cells: understanding ontogeny, subsets, functions, and their clinical applications.Molecular biomedicine · 2025Review
- Indoleamine 2, 3-dioxygenase Regulates the Differentiation of T Lymphocytes to Promote the Growth of Gastric Cancer Cells through the PI3K/Akt/mTOR Pathway.Cell biochemistry and biophysics · 2025Article
- Comprehensive single-cell analysis of triple-negative breast cancer based on cDC1 immune-related genes: prognostic model construction and immunotherapy potential.Discover oncology · 2025Article
- Pharmacological Phase I Clinical Trials in Pediatric Brain Tumors (1990-2024): A Historical Perspective.Oncology research · 2025Review
- Regulation of dendritic cell biology by amino acids and their transporters.Frontiers in immunology · 2025Review
- Review
- Review
- Bruton Tyrosine Kinase Inhibition Decreases Inflammation and Differentially Impacts Phagocytosis and Cellular Metabolism in Mouse- and Human-derived Myeloid Cells.ImmunoHorizons · 2024Article
- GNA15 facilitates the malignant development of thyroid carcinoma cells via the BTK-mediated MAPK signaling pathway.Histology and histopathology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 8 institutions in 2 countries.
Madhav D SharmaGeorgia Cancer Center, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA; Department of Pediatrics, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
Rafal PacholczykGeorgia Cancer Center, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
Huidong ShiGeorgia Cancer Center, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
Zuzana J BerrongGeorgia Cancer Center, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
Yousef ZakhariaDepartment of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA.
Austin GrecoDepartment of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA.
Chang-Sheng S ChangGeorgia Cancer Center, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA; Georgia Cancer Center, Bioinformatics Shared Resource, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
Sudharshan EathirajArQule, Burlington, MA 01803, USA.
Eugene KennedyLumos Pharma, Ames, IA 50010, USA.
Thomas CashDepartment of Pediatrics, Emory University, Atlanta, GA 30322, USA.
Roni J BollagGeorgia Cancer Center, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA; Department of Pathology, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
Ravindra KolheDepartment of Pathology, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
Ramses SadekGeorgia Cancer Center, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
Tracy L McGahaDepartment of Immunology, University of Toronto, Toronto, ON M5G 2M9, Canada.
Paulo RodriguezImmunology Department, Moffitt Cancer Center, Tampa, FL 33612, USA.
Jessica MandulaImmunology Department, Moffitt Cancer Center, Tampa, FL 33612, USA.
Bruce R BlazarDepartment of Pediatrics and Division of Blood and Marrow Transplantation, University of Minnesota, Minneapolis, MN 55455, USA.
Theodore S JohnsonGeorgia Cancer Center, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA; Department of Pediatrics, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
David H MunnGeorgia Cancer Center, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA; Department of Pediatrics, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA. Electronic address: dmunn@augusta.edu.
Augusta University · USMoffitt Cancer Center · USUniversity of Iowa · USArqule (United States) · USEmory University · USLumos Pharma (United States) · USUniversity of Minnesota · USUniversity of Toronto · CA
Funding
Trial Design and Biostatistical Support CoreP01CA065493 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI J SUNIL RAO · 1995 to 2026
$48.2MProject 4P01CA250984 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI STEWART, PAUL ALLEN · 2021 to 2025
$10.1MEnhancing Treg Therapeutic Efficacy in GVHDR01HL118979 · NHLBI · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R, HIPPEN, KELI L · 2014 to 2025
$6.7MReprogramming the TME for immunogenic antigen-presentationR01CA103320 · NCI · MEDICAL COLLEGE OF GEORGIA (MCG) · PI MUNN, DAVID H. · 2003 to 2024
$6.0MT-CELL TARGETING FOR GVHDR01HL056067 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI BLAZAR, BRUCE R · 1995 to 2022
$5.4MTranslational Genomics CoreP30GM114732 · NIGMS · LSU HEALTH SCIENCES CENTER · PI OCHOA, AUGUSTO C. · 2015 to 2019
$5.2MExploiting the VISTA Pathway to Prevent Acute GVHD and Control Steroid Refractory DiseaseR01HL155114 · NHLBI · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R, NOELLE, RANDOLPH J. · 2021 to 2024
$2.7MPlant-derived extracts regulate immunosuppressive myelopoiesis in Breast cancer patientsR01CA262121 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI RODRIGUEZ, PAULO CESAR · 2021 to 2025
$2.1MFunctional reprogramming of tumor-MDSC through antibody-based therapies targeting Notch ligandsR01CA233512 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI RODRIGUEZ, PAULO CESAR · 2019 to 2023
$2.0MStress Pathways in Tumors Drive Global MDSC Activity and Survival through ChopR01CA184185 · NCI · LSU HEALTH SCIENCES CENTER · PI RODRIGUEZ, PAULO CESAR · 2015 to 2019
$1.8MPTEN, Tregs and MDSCs in the tumor microenvironmentR01CA211229 · NCI · AUGUSTA UNIVERSITY · PI MUNN, DAVID H. · 2017 to 2021
$1.7MP53-dependent immunogenic DCs in the tumor microenvironmentR50CA232983 · NCI · AUGUSTA UNIVERSITY · PI SHARMA, MADHAV DATT · 2018 to 2020
$614kNCI NIH HHS P01 CA065493NCI NIH HHS P01 CA250984NCI NIH HHS R01 CA103320NCI NIH HHS R01 CA184185NCI NIH HHS R01 CA211229NCI NIH HHS R01 CA233512NCI NIH HHS R01 CA262121NCI NIH HHS R50 CA232983NHLBI NIH HHS R01 HL056067NHLBI NIH HHS R01 HL118979NHLBI NIH HHS R01 HL155114NIGMS NIH HHS P30 GM114732
Abstract
Monocytic-lineage inflammatory Ly6c
Indexed as
Agammaglobulinaemia Tyrosine KinaseAnimalsCell DifferentiationDendritic CellsFemaleHumansIndoleamine-Pyrrole 2,3,-DioxygenaseMaleMiceMonocytesNeoplasmsSignal TransductionT-LymphocytesTOR Serine-Threonine KinasesAgammaglobulinaemia Tyrosine KinaseIndoleamine-Pyrrole 2,3,-DioxygenaseTOR Serine-Threonine Kinasesantigen-presenting cellsBruton's tyrosine kinaseBTKchemotherapydendritic cellsIDOimmunotherapyindoleamine 2,3-dioxygenasetumors
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
NCT04049669ClinicalTrials.gov
NCT05106296ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.