ArticleCurrent biology : CB2021
Distinct "driving" versus "modulatory" influences of different visual corticothalamic pathways.
Article in Current biology : CB, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- The role of transthalamic pathways in perception.Communications biology · 2026Review
- Individual Pulvinar Neurons Integrate Cortical and Subcortical Signals.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Functional organization and natural scene responses across mouse visual cortical areas revealed with encoding manifolds.PloS one · 2026Article
- Layer 6 Corticothalamic Neurons Induce High Gamma Oscillations Through Cortico-cortical and Cortico-thalamo-cortical Pathways.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Effects of corticothalamic feedback depend on visual responsiveness and stimulus type.iScience · 2025Article
- Dual parallel stream-specific and generalized effects of corticogeniculate feedback on LGN neurons in primate and carnivore.Nature communications · 2025Article
- Complementary Organization of Mouse Driver and Modulator Cortico-thalamo-cortical Circuits.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Transthalamic Pathways for Cortical Function.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
- Convergent direct and indirect cortical streams shape avoidance decisions in mice via the midline thalamus.Nature communications · 2024Article
- AAV8 vector induced gliosis following neuronal transgene expression.Frontiers in neuroscience · 2024Article
- Highly branched and complementary distributions of layer 5 and layer 6 auditory corticofugal axons in mouse.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Recurrent Circuits Amplify Corticofugal Signals and Drive Feedforward Inhibition in the Inferior Colliculus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Primary somatosensory cortex bidirectionally modulates sensory gain and nociceptive behavior in a layer-specific manner.Nature communications · 2023Article
- Monosynaptic trans-collicular pathways link mouse whisker circuits to integrate somatosensory and motor cortical signals.PLoS biology · 2023Article
- Selective corticofugal modulation on sound processing in auditory thalamus of awake marmosets.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Diversity in spatial frequency, temporal frequency, and speed tuning across mouse visual cortical areas and layers.The Journal of comparative neurology · 2022Article
- Identification of visual cortex cell types and species differences using single-cell RNA sequencing.Nature communications · 2022Article
- Brain-wide mapping of inputs to the mouse lateral posterior (LP/Pulvinar) thalamus-anterior cingulate cortex network.The Journal of comparative neurology · 2022Article
- Conserved patterns of functional organization between cortex and thalamus in mice.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Corticothalamic Pathways From Layer 5: Emerging Roles in Computation and Pathology.Frontiers in neural circuits · 2021Review
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3 authors.
Funding
Abstract
Higher-order (HO) thalamic nuclei interact extensively and reciprocally with the cerebral cortex. These corticothalamic (CT) interactions are thought to be important for sensation and perception, attention, and many other important brain functions. CT projections to HO thalamic nuclei, such as the visual pulvinar, originate from two different excitatory populations in cortical layers 5 and 6, whereas first-order nuclei (such as the dorsolateral geniculate nucleus; dLGN) only receive layer 6 CT input. It has been proposed that these layer 5 and layer 6 CT pathways have different functional influences on the HO thalamus, but this has never been directly tested. By optogenetically inactivating different CT populations in the primary visual cortex (V1) and recording single-unit activity from V1, dLGN, and pulvinar of awake mice, we demonstrate that layer 5, but not layer 6, CT projections drive visual responses in the pulvinar, even while both pathways provide retinotopic, baseline excitation to their thalamic targets. Inactivating the superior colliculus also suppressed visual responses in the same subregion of the pulvinar, demonstrating that cortical layer 5 and subcortical inputs both contribute to HO visual thalamic activity-even at the level of putative single neurons. Altogether, these results indicate a functional division of "driver" and "modulator" CT pathways from V1 to the visual thalamus in vivo.
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