Evidence map›Paper›PMID 34614388›Full record

ArticleCurrent biology : CB2021

Spatial organization of transcribing loci during early genome activation in Drosophila.

Shao-Kuei Huang, Peter H Whitney, Sayantan Dutta, Stanislav Y Shvartsman, Christine A Rushlow

Open access · greenAbstract read
In one paragraph

Article in Current biology : CB, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
2.5field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 47 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Cell-cycle-regulated transcriptional pausing ofMolecular biology of the cell · 2025
    Article
  11. Article
  12. Article
  13. Transcription regulation by biomolecular condensates.Nature reviews. Molecular cell biology · 2025
    Review
  14. Review
  15. Zelda is dispensable forMolecular biology of the cell · 2025
    Article
  16. Article
  17. Article
  18. Cell cycle-regulated transcriptional pausing ofbioRxiv : the preprint server for biology · 2024
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Shao-Kuei HuangDepartment of Biology, New York University, New York, NY 10003, USA.
Peter H WhitneyDepartment of Biology, New York University, New York, NY 10003, USA.
Sayantan DuttaThe Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA; Department of Chemical and Biological Engineering, Princeton University, Princeton, NJ 08544, USA.
Stanislav Y ShvartsmanThe Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA; Department of Chemical and Biological Engineering, Princeton University, Princeton, NJ 08544, USA; Center for Computational Biology, Flatiron Research Institute, New York, NY 10010, USA.
Christine A RushlowDepartment of Biology, New York University, New York, NY 10003, USA. Electronic address: chris.rushlow@nyu.edu.
New York University · USPrinceton University · US

Funding

Regulation of zygotic genome activation by ZeldaR01GM063024 · NIGMS · NEW YORK UNIVERSITY · PI RUSHLOW, CHRISTINE A · 2002 to 2020
$5.2M
TRAINING PROGRAM IN DEVELOPMENTAL GENETICS.T32HD007520 · NICHD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI TREISMAN, JESSICA E · 1999 to 2023
$3.9M
Collective dynamics in cell clustersR01GM134204 · NIGMS · PRINCETON UNIVERSITY · PI Stanislav Y. Shvartsman · 2019 to 2026
$2.6M
NICHD NIH HHS T32 HD007520NIGMS NIH HHS R01 GM063024NIGMS NIH HHS R01 GM134204
6 · The paper itself

Abstract

The early Drosophila embryo provides unique experimental advantages for addressing fundamental questions of gene regulation at multiple levels of organization, from individual gene loci to the entire genome. Using 1.5-h-old Drosophila embryos undergoing the first wave of genome activation,

Indexed as

DrosophilaDrosophila ProteinsAnimalsDrosophila melanogasterGene Expression Regulation, DevelopmentalNuclear ProteinsRNA Polymerase IITranscriptional ActivationTranscription FactorsDrosophila ProteinsNuclear ProteinsRNA Polymerase IITranscription Factorsgenome activationhistone locus bodyRNA polymerase IIspecklesZelda

Identifiers

PMID34614388
PMCPMC8612988
OpenAlexW3202731102

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.