ArticleNano letters2021
Nanocomposite Scaffolds for Monitoring of Drug Diffusion in Three-Dimensional Cell Environments by Surface-Enhanced Raman Spectroscopy.
Article in Nano letters, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- High-YieldACS nano · 2025Article
- Surface-Enhanced Raman Spectroscopy (SERS) Based Biological and Environmental 2D and 3D Imaging.ACS environmental Au · 2025Review
- Plasmonic-Hydrogel Hybrid Biomaterials Via In Situ Seeded Growth.Angewandte Chemie (International ed. in English) · 2025Article
- Design Principles Of Inorganic-Protein Hybrid Materials for Biomedicine.Exploration (Beijing, China) · 2025Review
- A Bioinert Hydrogel Framework for Precision 3D Cell Cultures: Advancing Automated High-Content and High-Throughput Drug Screening.Small science · 2025Article
- Surface-Enhanced Raman Spectroscopy for Biomedical Applications: Recent Advances and Future Challenges.ACS applied materials & interfaces · 2025Review
- Advances in Surface-Enhanced Raman Spectroscopy for Therapeutic Drug Monitoring.Molecules (Basel, Switzerland) · 2024Review
- Surface-Enhanced Raman Spectroscopy at the Interface between Drug Discovery and Personalized Medicine.The journal of physical chemistry. C, Nanomaterials and interfaces · 2024Review
- Review
- Growing Gold Nanostars on 3D Hydrogel Surfaces.Chemistry of materials : a publication of the American Chemical Society · 2024Article
- SERS in 3D cell models: a powerful tool in cancer research.Chemical Society reviews · 2024Review
- A Scaffold-Assisted 3D Cancer Cell Model for Surface-Enhanced Raman Scattering-Based Real-Time Sensing and Imaging.ACS nano · 2024Article
- Diffusion-Limited Processes in Hydrogels with Chosen Applications from Drug Delivery to Electronic Components.Molecules (Basel, Switzerland) · 2023Review
- Nanocomposite Hydrogels as Functional Extracellular Matrices.Gels (Basel, Switzerland) · 2023Review
- 3D printed scaffolds: Challenges toward developing relevant cellularBiomaterials and biosystems · 2022Article
- Prospects of Surface-Enhanced Raman Spectroscopy for Biomarker Monitoring toward Precision Medicine.ACS photonics · 2022Review
- Human metabolite detection by surface-enhanced Raman spectroscopy.Materials today. Bio · 2022Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Monitoring dynamic processes in complex cellular environments requires the integration of uniformly distributed detectors within such three-dimensional (3D) networks, to an extent that the sensor could provide real-time information on nearby perturbations in a non-invasive manner. In this context, the development of 3D-printed structures that can function as both sensors and cell culture platforms emerges as a promising strategy, not only for mimicking a specific cell niche but also toward identifying its characteristic physicochemical conditions, such as concentration gradients. We present herein a 3D cancer model that incorporates a hydrogel-based scaffold containing gold nanorods. In addition to sustaining cell growth, the printed nanocomposite inks display the ability to uncover drug diffusion profiles by surface-enhanced Raman scattering, with high spatiotemporal resolution. We additionally demonstrate that the acquired information could pave the way to designing novel strategies for drug discovery in cancer therapy, through correlation of drug diffusion with cell death.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.