Evidence map›Paper›PMID 34614212›Full record

ArticleCancer2022

Trajectories of fear of cancer recurrence in young breast cancer survivors.

Lidia Schapira, Yue Zheng, Shari I Gelber, Philip Poorvu, Kathryn J Ruddy, Rulla M Tamimi, Jeffrey Peppercorn, Steven E Come, Virginia F Borges, Ann H Partridge and 1 more

Erratum issued Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT01468246 (Helping Ourselves, Helping Others), which is not on this map. Cited by 77 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed, 6 pooled it
5.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01468246 active not recruitingnot on this map

Helping Ourselves, Helping Others: The Young Women's Breast Cancer Study

TypeobservationalSponsorDana-Farber Cancer InstituteRan2006 to 2035Enrolled1,302ConditionsBreast Cancer
3 · Its place in the literature

Who cites it

77 citing papers in PubMed, 6 syntheses or guidelines pooled it, 110 citations in OpenAlex.

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17 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 1 country.

Lidia SchapiraStanford Cancer Institute, Palo Alto, California.ORCID 0000-0003-1431-6543
Yue ZhengDana-Farber Cancer Institute, Boston, Massachusetts.
Shari I GelberDana-Farber Cancer Institute, Boston, Massachusetts.
Philip PoorvuDana-Farber Cancer Institute, Boston, Massachusetts.
Kathryn J RuddyMayo Clinic, Rochester, Minnesota.ORCID 0000-0001-6298-332X
Rulla M TamimiWeill Cornell Medicine, New York, New York.
Jeffrey PeppercornMassachusetts General Hospital, Boston, Massachusetts.
Steven E ComeBeth Israel Deaconess Medical Center, Boston, Massachusetts.
Virginia F BorgesUniversity of Colorado Cancer Center, Aurora, Colorado.
Ann H PartridgeDana-Farber Cancer Institute, Boston, Massachusetts.ORCID 0000-0002-4722-4824
Shoshana M RosenbergDana-Farber Cancer Institute, Boston, Massachusetts.ORCID 0000-0002-0074-6385
Dana-Farber Cancer Institute · USCornell University · USBeth Israel Deaconess Medical Center · USMassachusetts General Hospital · USMayo Clinic · USPalo Alto Institute · USUniversity of Colorado Cancer Center · US

Funding

Improving surgical decision-making in young women with breast cancerK01HS023680 · AHRQ · DANA-FARBER CANCER INST · PI ROSENBERG, SHOSHANA M · 2015 to 2019
$594k
Agency for Healthcare Research and Quality K01HS023680AHRQ HHS K01 HS023680Breast Cancer Research Foundation BCRF17-121Conquer Cancer FoundationSusan G. Komen for the Cure SAC1000008
6 · The paper itself

Abstract

backgroundFear of cancer recurrence (FCR) is more intense in younger women. Because FCR is a powerful determinant of quality of life, identifying those at risk for persistently elevated FCR can inform timing of interventions.

methodsA total of 965 women with stage 0 to stage III breast cancer enrolled in the Young Women's Breast Cancer Study, a prospective cohort of women diagnosed with breast cancer at age ≤40 years, completed the 3-item Lasry Fear of Recurrence Index. Group-based trajectory modeling was used to classify distinct FCR patterns from baseline through 5 years post-diagnosis. Multinomial logistic regression was used to identify patient, disease, and treatment characteristics associated with each trajectory.

resultsFive FCR trajectories were identified with the majority of participants having moderate (33.1%) or high FCR (27.6%) that improved over time. A total of 6.9% participants had moderate FCR that worsened, whereas 21.7% had high FCR at baseline that remained high throughout. In the fully adjusted multinomial model, stages II and III (vs stage I) were associated with lower odds (of being in the high/stable trajectory). White (vs non-White) were associated with higher odds of being in a trajectory that improved over time.

conclusionsAlthough FCR improves over time for many young women with breast cancer, approximately one-third had FCR that was severe and did not improve or worsened over 5 years after diagnosis. Ongoing monitoring is warranted, with early referral to mental health professionals indicated for those at highest risk for unresolved FCR. LAY SUMMARY: Fear of recurrence is common among young women with breast cancer. The authors followed a large cohort of young women diagnosed with breast cancer when they were 40 years of age and younger, and found 5 distinct trajectories that show moderate and severe fears do not always improve over time and may require targeted mental health intervention.

Indexed as

Breast NeoplasmsCancer SurvivorsAdultFearFemaleHumansNeoplasm Recurrence, LocalProspective StudiesQuality of Lifeanxietybreast cancercancer survivorsfear of cancer recurrencequality of life

Identifiers

PMID34614212
PMCPMC9397577
OpenAlexW3204207402

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.