Evidence map›Paper›PMID 34614172›Full record

SynthesisJournal of Crohn's & colitis2022

Defining Transabdominal Intestinal Ultrasound Treatment Response and Remission in Inflammatory Bowel Disease: Systematic Review and Expert Consensus Statement.

Johan F K F Ilvemark, Tawnya Hansen, Thomas M Goodsall, Jakob B Seidelin, Heba Al-Farhan, Mariangela Allocca, Jakob Begun, Robert V Bryant, Dan Carter, Britt Christensen and 11 more

Registry-linked trialOpen access · bronzeAbstract readSystematic ReviewConsensus Statement
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of Crohn's & colitis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07726888 (Efficacy and Safety of Guselkumab in Patients With Moderate-to-Severe Ulcerative Colitis), which is not on this map. Cited by 72 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed, 5 pooled it
14.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07726888 recruitingnot on this mapstarted 2026, after this paper: background citation

Efficacy and Safety of Guselkumab in Patients With Moderate-to-Severe Ulcerative Colitis:A Real-World Prospective Cohort Study.

Typeobservational_patient_registrySponsorSecond Affiliated Hospital of Wenzhou Medical UniversityRan2026 to 2028Enrolled97ConditionsUlcerative Colitis (Disorder), GuselkumabArmsGuselkumab
3 · Its place in the literature

Who cites it

72 citing papers in PubMed, 5 syntheses or guidelines pooled it, 152 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Trial
  7. Trial
  8. Trial
  9. Trial
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review

12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

21 authors at 16 institutions in 11 countries.

Johan F K F IlvemarkDepartment of Gastroenterology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-7792-9008
Tawnya HansenDepartment of Medicine, Section Gastroenterology, University of Manitoba, Manitoba, MN, Canada.
Thomas M GoodsallDepartment of Gastroenterology, John Hunter Hospital, Newcastle, NSW, Australia.
Jakob B SeidelinDepartment of Gastroenterology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark.
Heba Al-FarhanDepartment of Gastroenterology, Department of Internal Medicine, Al Amiri Hospital, Kuwait City, Kuwait.
Mariangela AlloccaIRCCS Humanitas Research Hospital, Rozzano, Milan, Italy.
Jakob BegunMater Research Institute, University of Queensland, Brisbane, QLD, Australia.ORCID 0000-0001-5256-7672
Robert V BryantDepartment of Gastroenterology, Queen Elizabeth Hospital, Adelaide, SA, Australia.
Dan CarterDepartment of Gastroenterology, Chaim Sheba Medical Center, Tel Aviv University, Tel Aviv, Israel.
Britt ChristensenDepartment of Gastroenterology, TRoyal Melbourne Hospital, Melbourne, VIC, Australia.ORCID 0000-0002-8746-4275
Marla C DubinskyDepartment of Pediatrics, Susan and Leonard Feinstein IBD Clinical Center, Icahn School of Medicine, New York, NY, USA.
Krisztina B GecseDepartment of Gastroenterology and Hepatology, Amsterdam University Medical Center, Amsterdam, The Netherlands.
Torsten KucharzikDepartment of Gastroenterology, University Teaching Hospital Lüneburg, Lüneburg, Germany.
Cathy LuDivision of Gastroenterology and Hepatology, Department of Medicine. University of Calgary, Calgary, AB, Canada.
Christian MaaserOutpatients Department of Gastroenterology, University Teaching Hospital Lüneburg, Lüneburg, Germany.
Giovanni MaconiGastroenterology Unit, Department of Biomedical and Clinical Sciences L. Sacco, University of Milan, Milan, Italy.
Kim NylundNational Centre for Ultrasound in Gastroenterology, Haukeland University Hospital, Bergen, Norway.
Carolina PalmelaDivision of Gastroenterology, Surgical Department, Hospital Beatriz Angelo, Loures, Portugal.
Stephanie R WilsonDepartment of Radiology and Medicine, University of Calgary, Calgary, AB, Canada.
Kerri NovakDivision of Gastroenterology and Hepatology, Department of Medicine. University of Calgary, Calgary, AB, Canada.
Rune WilkensGastrounit, Division of Medicine, Hvidovre University Hospital, Copenhagen, Denmark.ORCID 0000-0002-4928-4708
University of Calgary · CAUniversity of Copenhagen · DKKlinikum Lüneburg · DEAmiri Hospital · KWAmsterdam University Medical Centers · NLFeinstein Institute for Medical Research · USHaukeland University Hospital · NOHospital Beatriz Ângelo · PTHumanitas University · ITJohn Hunter Hospital · AUQueen Elizabeth Hospital · AUTel Aviv University · ILThe Royal Melbourne Hospital · AUThe University of Queensland · AUUniversity of Manitoba · CAUniversity of Milan · IT

Funding

Leona M. and Harry B. Helmsley Charitable Trust
6 · The paper itself

Abstract

BACKGROUND AND

aimsNo consensus exists on defining intestinal ultrasound response, transmural healing, or transmural remission in inflammatory bowel disease, nor clear guidance for optimal timing of assessment during treatment. This systematic review and expert consensus study aimed to define such recommendations, along with key parameters included in response reporting.

methodsElectronic databases were searched from inception to July 26, 2021, using pre-defined terms. Studies were eligible if at least two intestinal ultrasound [IUS] assessments at different time points during treatment were reported, along with an appropriate reference standard. The QUADAS-2 tool was used to examine study-level risk of bias. An international panel of experts [n = 18] rated an initial 196 statements [RAND/UCLA process, scale 1-9]. Two videoconferences were conducted, resulting in additional ratings of 149 and 13 statements, respectively.

resultsOut of 5826 records, 31 full-text articles, 16 abstracts, and one research letter were included; 83% [40/48] of included studies showed a low concern of applicability, and 96% [46/48] had a high risk of bias. A consensus was reached on 41 statements, with clear definitions of IUS treatment response, transmural healing, transmural remission, timing of assessment, and general considerations when using intestinal ultrasound in inflammatory bowel disease.

conclusionsResponse criteria and time points of response assessment varied between studies, complicating direct comparison of parameter changes and their relation to treatment outcomes. To ensure a unified approach in routine care and clinical trials, we provide recommendations and definitions for key parameters for intestinal ultrasound response, to incorporate into future prospective studies.

Indexed as

Inflammatory Bowel DiseasesChronic DiseaseConsensusHumansIntestinesProspective StudiesUltrasonographyinflammatory bowel diseaseIntestinal ultrasoundtransmural healingtransmural remissiontreatment response

Identifiers

PMID34614172
PMCPMC9089416
OpenAlexW3201771858

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.