ArticleScience advances2021
A GTP-synthesizing ribozyme selected by metabolic coupling to an RNA polymerase ribozyme.
Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Nitrogen-modified atmosphere with re-aeration storage triggers deterioration in paddy rice by disrupting central carbon metabolism.Food chemistry: X · 2026Article
- A ribozyme ligase that requires a 3' terminal phosphate on its RNA substrate.Nature communications · 2026Article
- A GTP synthase ribozyme with increased GTP turnover.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- The Exceptional Solubility of Cyclic Trimetaphosphate in the Presence of MgLife (Basel, Switzerland) · 2026Article
- Assembly of catalytic complexes from randomized oligonucleotides.Science advances · 2025Article
- Principles ofJournal of the Royal Society, Interface · 2025Article
- Evolution of the substrate specificity of an RNA ligase ribozyme from phosphorimidazole to triphosphate activation.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Constraint on an RNA world on montmorillonite clay.Biophysical journal · 2024Article
- A ribozyme that uses lanthanides as cofactor.Nucleic acids research · 2023Article
- Minimizing amplification bias during reverse transcription for in vitro selections.RNA (New York, N.Y.) · 2023Article
- In vitro evolution of ribonucleases from expanded genetic alphabets.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Prebiotic Chemistry: The Role of Trimetaphosphate in Prebiotic Chemical Evolution.Frontiers in chemistry · 2022Review
- Water/Oil Emulsions with Controlled Droplet Sizes forACS omega · 2021Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Synthesis of RNA in early life forms required chemically activated nucleotides, perhaps in the same form of nucleoside 5′-triphosphates (NTPs) as in the contemporary biosphere. We show the development of a catalytic RNA (ribozyme) that generates the nucleoside triphosphate guanosine 5′-triphosphate (GTP) from the nucleoside guanosine and the prebiotically plausible cyclic trimetaphosphate. Ribozymes were selected from 1.6 × 10
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Registered trials
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