Evidence map›Paper›PMID 34613617›Full record

Trial reportCancer2022

Dispositional hope as a potential outcome parameter among patients with advanced malignancy: An analysis of the ENABLE database.

Benjamin W Corn, David B Feldman, Jay G Hull, Mark A O'Rourke, Marie A Bakitas

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  8. Living with brain metastasis - a qualitative study of patients' and family members' coping strategies.International journal of qualitative studies on health and well-being · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Benjamin W CornDepartment of Oncology, Shaare Zedek Cancer Center, Jerusalem, Israel.ORCID 0000-0002-2881-0326
David B FeldmanDepartment of Counseling Psychology, Santa Clara University, Santa Clara, California.
Jay G HullDepartment of Psychological and Brain Sciences, Dartmouth College, Hanover, New Hampshire.
Mark A O'RourkePrisma Health Upstate Cancer Institute, Greenville, South Carolina.
Marie A BakitasSchool of Nursing, University of Alabama at Birmingham, Birmingham, Alabama.

Funding

Improving Palliative Care for Patients with CancerR01CA101704 · NCI · DARTMOUTH COLLEGE · PI HEGEL, MARK T · 2003 to 2007
$2.8M
Early vs. Later Palliative Cancer Care: Clinical and Biobehavioral EffectsR01NR011871 · NINR · DARTMOUTH COLLEGE · PI BAKITAS, MARIE ANNE · 2009 to 2011
$1.4M
NCI NIH HHS R01 CA101704NINR NIH HHS R01 NR011871Pamm Gross Kahane Research Institute of Life's Door
6 · The paper itself

Abstract

backgroundHopefulness, whether inherently present (dispositional hope) or augmented (by enhancement techniques), may affect outcomes. This study was performed to determine the association of dispositional hope with survival among patients diagnosed with advanced cancer.

methodsData from ENABLE (Educate, Nurture, Advise, Before Life Ends), a palliative care intervention, were reanalyzed to determine the association of higher dispositional hope and patient survival. This was a secondary analysis of data combined from the ENABLE II and ENABLE III randomized controlled trials (RCTs) with respect to dispositional hope and survival. A dispositional hope index was created from 3 hope items from 2 validated baseline questionnaires. Dispositional hope and survival data were collected during the 2 RCTs. In ENABLE II, participants were randomly assigned to the ENABLE intervention or to usual care. In ENABLE III, participants were randomly assigned to receive the intervention immediately or 12 weeks after enrollment.

resultsIn all, 529 persons were included in Cox proportional hazards regression analyses to model the effects of dispositional hope on survival. An initial analysis without covariates yielded a significant effect of hope (Wald statistic, 8.649; hazard ratio, 0.941; confidence interval, 0.904-0.980; P = .003), such that higher dispositional hope was associated with longer survival. In a subsequent analysis that included all covariates, the effect of dispositional hope approached statistical significance (Wald statistic, 2.96; hazard ratio, 0.933; confidence interval, 0.863-1.010; P = .085).

conclusionsHigher levels of dispositional hope were associated with longer survival in patients with advanced cancer. Prospective trials are needed to determine the effects of dispositional and augmented hope on the outcomes of patients with advanced cancer.

Indexed as

NeoplasmsPalliative CareHopeHumansQuality of LifeSurveys and Questionnairesadvanced cancerEducate, Nurture, Advise, Before Life Ends (ENABLE)hopepalliationsurvival

Identifiers

PMID34613617
PMCPMC10008020

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.