Evidence map›Paper›PMID 34613581›Full record

SynthesisJournal of neuro-oncology2021

Predictors of mortality and tumor recurrence in desmoplastic infantile ganglioglioma and astrocytoma-and individual participant data meta-analysis (IPDMA).

Shelly Wang, Matthew Z Sun, I Joshua Abecassis, Alexander G Weil, George M Ibrahim, Aria Fallah, Chibawanye Ene, Sarah E S Leary, Bonnie L Cole, Christina M Lockwood and 5 more

Open access · greenAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of neuro-oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Desmoplastic infantile ganglioglioma and astrocytoma: A narrative review of the literature.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 2 countries.

Shelly WangDivision of Neurosurgery, Brain Institute, Nicklaus Children's Hospital, Miami, FL, USA.
Matthew Z SunDepartment of Neurosurgery, University of California Los Angeles, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0003-1332-3696
I Joshua AbecassisDepartment of Neurosurgery, University of Louisville, Louisville, KY, USA.
Alexander G WeilDepartment of Surgery, Université de Montréal, Montreal, QC, Canada.
George M IbrahimDivision of Pediatric Neurosurgery, Sick Kids Toronto, University of Toronto, Toronto, ON, Canada.
Aria FallahDepartment of Neurosurgery, University of California Los Angeles, Los Angeles, CA, USA.
Chibawanye EneDepartment of Neurological Surgery, University of Washington and Seattle Children's Hospital, Seattle, WA, USA.
Sarah E S LearyDivision of Hematology Oncology, Department of Pediatrics, University of Washington and Seattle Children's Hospital, Seattle, WA, USA.
Bonnie L ColeDepartment of Anatomic Pathology, Seattle Children's Hospital, University of Washington and Laboratories, Seattle, WA, USA.
Christina M LockwoodDepartment of Laboratory Medicine, University of Washington and Seattle Children's Hospital, Seattle, WA, USA.
James M OlsonDivision of Hematology Oncology, Department of Pediatrics, University of Washington and Seattle Children's Hospital, Seattle, WA, USA.
J Russell GeyerDivision of Hematology Oncology, Department of Pediatrics, University of Washington and Seattle Children's Hospital, Seattle, WA, USA.
Richard G EllenbogenDepartment of Neurological Surgery, University of Washington and Seattle Children's Hospital, Seattle, WA, USA.
Jeffrey G OjemannDepartment of Neurological Surgery, University of Washington and Seattle Children's Hospital, Seattle, WA, USA.
Anthony C WangDepartment of Neurosurgery, University of California Los Angeles, Los Angeles, CA, USA. ACWang@mednet.ucla.edu.
Seattle Children's Hospital · USUniversity of California, Los Angeles · USUniversité de Montréal · CAUniversity of Louisville · USUniversity of Miami · USUniversity of Toronto · CA

Funding

UCLA SPORE in Brain CancerP50CA211015 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI David A. Nathanson · 2017 to 2026
$25.2M
UCLA Neurosurgery Research Training and Education ProgramR25NS079198 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LIAU, LINDA M · 2012 to 2021
$1.2M
NCI NIH HHS P50 CA211015NINDS NIH HHS R25 NS079198
6 · The paper itself

Abstract

purposeDesmoplastic infantile astrocytoma (DIA) and desmoplastic infantile ganglioglioma (DIG) are classified together as grade I neuronal and mixed neuronal-glial tumor of the central nervous system by the World Health Organization (WHO). These tumors are rare and have not been well characterized in terms of clinical outcomes. We aimed to identify clinical predictors of mortality and tumor recurrence/progression by performing an individual patient data meta-analysis (IPDMA) of the literature.

methodsA systematic literature review from 1970 to 2020 was performed, and individualized clinical data for patients diagnosed with DIA/DIG were extracted. Aggregated data were excluded from collection. Outcome measures of interest were mortality and tumor recurrence/progression, as well as time-to-event (TTE) for each of these. Participants without information on these outcome measures were excluded. Cox regression survival analyses were performed to determine predictors of mortality and tumor recurrence / progression.

resultsWe identified 98 articles and extracted individual patient data from 188 patients. The cohort consisted of 58.9% males with a median age of 7 months. The majority (68.1%) were DIGs, while 24.5% were DIAs and 7.5% were non-specific desmoplastic infantile tumors; DIAs presented more commonly in deep locations (p = 0.001), with leptomeningeal metastasis (p = 0.001), and was associated with decreased probability of gross total resection (GTR; p = 0.001). Gender, age, and tumor pathology were not statistically significant predictors of either mortality or tumor recurrence/progression. On multivariate survival analysis, GTR was a predictor of survival (HR = 0.058; p = 0.007) while leptomeningeal metastasis at presentation was a predictor of mortality (HR = 3.27; p = 0.025). Deep tumor location (HR = 2.93; p = 0.001) and chemotherapy administration (HR = 2.02; p = 0.017) were associated with tumor recurrence/progression.

conclusionOur IPDMA of DIA/DIG cases reported in the literature revealed that GTR was a predictor of survival while leptomeningeal metastasis at presentation was associated with mortality. Deep tumor location and chemotherapy were associated with tumor recurrence / progression.

Indexed as

AstrocytomaBrain NeoplasmsGangliogliomaNeoplasm Recurrence, LocalFemaleHumansInfantMaleMeningeal CarcinomatosisAstrocytomaBRAFDesmoplasticGangliogliomaInfantile

Identifiers

PMID34613581
PMCPMC9448015
OpenAlexW3201958949

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.