ArticleAnnals of surgical oncology2022
Oncoplastic Breast-Conserving Surgery for Synchronous Multicentric and Multifocal Tumors: Is It Oncologically Safe? A Retrospective Matched-Cohort Analysis.
Article in Annals of surgical oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07677956 (Safety Evaluation of Breast-Conserving Surgery for Multifocal or Multicentric Breast Cancer), which is not on this map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Safety Evaluation of Breast-Conserving Surgery for Multifocal or Multicentric Breast Cancer: A Prospective Cohort Study
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Extreme oncoplasty: past, present and future.Frontiers in oncology · 2023Pooled it
- Breast-Conserving Surgery in Multicentric Breast Cancer: Evolving Evidence and Patient Selection.Cancers · 2026Review
- Oncoplastic Breast Surgery: Bridging Oncological Safety and Aesthetic Excellence in the Era of Precision Surgery.Cureus · 2026Review
- Clinicopathological characteristics and factors associated with axillary lymph node metastasis in multifocal/multicentric versus unifocal breast cancer: a retrospective study.Frontiers in oncology · 2026Article
- Cohort study comparing volume replacement oncoplastic breast surgery with standard wide local excision for breast cancer.Gland surgery · 2025Article
- Clinical and patient-reported outcomes in women offered oncoplastic breast-conserving surgery as an alternative to mastectomy: ANTHEM multicentre prospective cohort study.The British journal of surgery · 2024Article
- Performance of an AI-powered visualization software platform for precision surgery in breast cancer patients.NPJ breast cancer · 2024Article
- Combining Wise-pattern Volume Displacement and Autologous Volume Replacement to Facilitate Oncoplastic Breast Conservation.Plastic and reconstructive surgery. Global open · 2024Article
- Oncoplastic breast-conserving surgery (OBCS)Gland surgery · 2024Article
- Expanded indications for breast-conserving surgery with oncoplastic approaches compared to conventional approaches: a single-center retrospective comparative cohort study.Gland surgery · 2023Article
- A Look at the Other Side: High-Risk Lesions and Occult Contralateral Malignancy in Symmetry Procedures for Patients Undergoing Oncoplastic Breast-Conserving Surgery.Annals of surgical oncology · 2023Article
- ASO Author Reflections: Considerations for the Contralateral Breast in Patients Undergoing Oncoplastic Breast-Conserving Surgery.Annals of surgical oncology · 2023Article
- Combining Multiple Oncoplastic Techniques to Facilitate Extreme Oncoplastic Breast Conservation.Plastic and reconstructive surgery. Global open · 2023Article
- Local Recurrence After Breast-Conserving Therapy in Patients With Multiple Ipsilateral Breast Cancer: Results From ACOSOG Z11102 (Alliance).Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2023Article
- Dual-Layer Rotation: A Versatile Therapeutic Mammoplasty Technique.Annals of surgical oncology · 2022Article
- Article
Corrections and comments
- Commented on by
Authors and funding
13 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOncoplastic surgery is a well-established approach that combines breast-conserving treatment for breast cancer and plastic surgery techniques. Although this approach already has been described for multicentric and multifocal tumors, no long-term oncologic follow-up evaluation and no comparison with patients undergoing mastectomy have been published. This study aimed to evaluate whether oncoplastic surgery is a safe and reliable treatment for managing invasive primary multicentric and multifocal breast cancer.
methodsThe study compared a consecutive series of 100 patients with multicentric or multifocal tumors who had undergone oncoplastic surgery (study group) with 100 patients who had multicentric or multifocal tumors and had undergone mastectomy (control group) during a prolonged period. The end points evaluated were disease-free survival (DFS), overall survival (OS), cumulative incidence of local recurrence (CI-L), regional recurrence (CI-R), and distant recurrence (CI-D), all measured from the date of surgery.
resultsThe OS and DFS were similar between the two groups. The incidence of local events was higher in the oncoplastic group, whereas the incidence of regional events was slightly higher in the mastectomy group. These differences were not statistically significant. The cumulative incidence of distant events was similar between the two groups.
conclusionsTo the authors' knowledge, the current study provides the best available evidence suggesting that the oncoplastic approach is a safe and reliable treatment for managing invasive multifocal and multicentric breast cancers.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.