Evidence map›Paper›PMID 34613513›Full record

ArticleResearch on child and adolescent psychopathology2022

Methylphenidate Improves Autonomic Functioning among Youth with Attention-Deficit/Hyperactivity Disorder.

Stephanie S J Morris, Erica D Musser, Rachel B Tenenbaum, Anthony R Ward, Joseph S Raiker, Erika K Coles

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Research on child and adolescent psychopathology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Stephanie S J MorrisCenter for Children and Families, Department of Psychology, Florida International University, Miami, FL, USA. smorr064@fiu.ed.ORCID 0000-0002-3903-1715
Erica D MusserCenter for Children and Families, Department of Psychology, Florida International University, Miami, FL, USA. emusser@fiu.edu.
Rachel B TenenbaumDepartment of Pediatrics, Texas Children's Hospital, Baylor College of Medicine, Houston, TX , USA.
Anthony R WardCenter for Children and Families, Department of Psychology, Florida International University, Miami, FL, USA.
Joseph S RaikerCenter for Children and Families, Department of Psychology, Florida International University, Miami, FL, USA.
Erika K ColesCenter for Children and Families, Department of Psychology, Florida International University, Miami, FL, USA.
Florida Department of Children and Families · USBaylor College of Medicine · US

Funding

Examining Tolerance to CNS Stimulants in ADDR01MH099030 · NIMH · FLORIDA INTERNATIONAL UNIVERSITY · PI PELHAM, WILLIAM E, SWANSON, JAMES M · 2013 to 2017
$3.3M
Emotional Systems in Attention-Deficit/Hyperactivity DisorderK23MH117280 · NIMH · FLORIDA INTERNATIONAL UNIVERSITY · PI MUSSER, ERICA D · 2019 to 2022
$707k
Heterogeneity in ADHD: Autonomic, Behavior, Emotion, and Treatment ResponseR03MH110812 · NIMH · FLORIDA INTERNATIONAL UNIVERSITY · PI MUSSER, ERICA D · 2016 to 2017
$141k
NIMH NIH HHS K23 MH117280NIMH NIH HHS R01 MH099030NIMH NIH HHS R03 MH110812
6 · The paper itself

Abstract

Psychostimulants are commonly prescribed medications for youth with attention-deficit/hyperactivity disorder (ADHD). Limited studies have evaluated how psychostimulants (e.g., methylphenidate [MPH]) impact autonomic nervous system (ANS) indexes among youth with ADHD. Understanding the effects of MPH on autonomic functioning is essential, given that youth with ADHD have been shown to experience atypical autonomic functioning (i.e., reduced activity across both sympathetic and parasympathetic branches) compared to typically developing youth. The current study investigated how a specific psychostimulant, Osmotic Release Oral System [OROS] MPH, impacts parasympathetic (indexed by respiratory sinus arrhythmia [RSA]) and sympathetic (indexed by electrodermal activity [EDA]) functioning among youth with ADHD via a within-subjects, double-masked, cross-over design. Two hundred fifty-six participants (157 youth with ADHD), ages 5 to 13 years, completed a two-minute resting baseline task while electrocardiograph and electrodermal data were obtained. Youth with ADHD completed the resting baseline task twice, 3 weeks apart, once during active medication and once during placebo conditions (counterbalanced). Typically developing youth were assessed without medication or placebo. Youth with ADHD during the placebo condition exhibited reduced RSA and EDA compared to typically developing youth. In contrast, youth with ADHD during the medication condition did not differ significantly from typically developing youth with respect to either RSA nor EDA. As such, OROS MPH appears to normalize RSA and EDA levels among youth with ADHD to levels comparable to typically developing youth. Future studies including indexes of the ANS among youth with ADHD are urged to consider the impact of MPH.

Indexed as

Attention Deficit Disorder with HyperactivityCentral Nervous System StimulantsMethylphenidateRespiratory Sinus ArrhythmiaAdolescentChildChild, PreschoolCross-Over StudiesDouble-Blind MethodHumansCentral Nervous System StimulantsMethylphenidateAttention-deficit/hyperactivity disorderElectrodermal activityMethylphenidateRespiratory sinus arrhythmia

Identifiers

PMID34613513
PMCPMC8983789
OpenAlexW3202270869

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.