Evidence map›Paper›PMID 34613500›Full record

ReviewCurrent psychiatry reports2021

Gonadal Hormone Influences on Sex Differences in Binge Eating Across Development.

Megan E Mikhail, Carolina Anaya, Kristen M Culbert, Cheryl L Sisk, Alexander Johnson, Kelly L Klump

Open access · greenAbstract readReview
In one paragraph

Review in Current psychiatry reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. Article
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  5. Discovering a new paradigm: Gut microbiota as a central modulator of sexual health.World journal of gastrointestinal pathophysiology · 2025
    Review
  6. Article
  7. Review
  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Megan E MikhailDepartment of Psychology, Michigan State University, East Lansing, MI, USA.
Carolina AnayaDepartment of Psychology, Michigan State University, East Lansing, MI, USA.
Kristen M CulbertDepartment of Family Medicine and Public Health Sciences, Wayne State University School of Medicine, Detroit, MI, USA.
Cheryl L SiskNeuroscience Program, Michigan State University, East Lansing, MI, USA.
Alexander JohnsonNeuroscience Program, Michigan State University, East Lansing, MI, USA.
Kelly L KlumpDepartment of Psychology, Michigan State University, East Lansing, MI, USA. klump@msu.edu.
Michigan State University · USWayne State University · US

Funding

A Twin Study of exogenous hormone exposure and risk for binge eatingR01MH111715 · NIMH · MICHIGAN STATE UNIVERSITY · PI KLUMP, KELLY L · 2017 to 2021
$4.0M
A Twin Study of Androgen Effects on Binge Eating Risk during Puberty in MalesR01MH118848 · NIMH · MICHIGAN STATE UNIVERSITY · PI CULBERT, KRISTEN, KLUMP, KELLY L · 2019 to 2024
$3.8M
NIMH NIH HHS R01 MH111715NIMH NIH HHS R01 MH118848
6 · The paper itself

Abstract

purpose of reviewBinge eating is a transdiagnostic symptom that disproportionately affects females. Sexually dimorphic gonadal hormones (e.g., estradiol, testosterone) substantially impact eating behavior and may contribute to sex differences in binge eating. We examine recent evidence for the role of gonadal hormones in binge eating risk across development. RECENT

findingsBoth organizational (long-lasting impact on the central nervous system (CNS)) and activational (transient influences on the CNS) hormone effects may contribute to sex differences in binge eating. Gonadal hormones also impact within-sex variability in binge eating, with higher estradiol levels in females and higher testosterone levels in males protective across development. Emerging evidence suggests that the impact of gonadal hormones may be greatest for people with other risk factors, including genetic, temperamental (e.g., high negative affect), and psychosocial (e.g., exposure to weight-based teasing) risk. Gonadal hormones contribute to sex differences and within-sex variability in binge eating across development.

Indexed as

Binge-Eating DisorderBulimiaFeeding BehaviorFemaleGonadal HormonesHumansMaleSex CharacteristicsGonadal HormonesBinge eatingEstradiolProgesteronePubertySex differencesTestosterone

Identifiers

PMID34613500
PMCPMC8576863
OpenAlexW3202347137

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.