Evidence map›Paper›PMID 34613493›Full record

ArticleEuropean spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society2022

Morphometric measurements can improve prediction of progressive vertebral deformity following vertebral damage.

Jin Luo, Patricia Dolan, Michael A Adams, Deborah J Annesley-Williams

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Article in European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Jin LuoSchool of Biomedical Sciences, University of West London, St. Mary's Rd., Ealing, London, W5 5RF, UK. jin.luo@uwl.ac.uk.ORCID 0000-0001-5451-9535
Patricia DolanCentre for Applied Anatomy, University of Bristol, Bristol, BS2 8EJ, UK.
Michael A AdamsCentre for Applied Anatomy, University of Bristol, Bristol, BS2 8EJ, UK.
Deborah J Annesley-WilliamsRoyal Derby Hospital, Derby, DE22 3NE, UK.
University of Bristol · GBRoyal Derby Hospital · GBUniversity of West London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeA damaged vertebral body can exhibit accelerated 'creep' under constant load, leading to progressive vertebral deformity. However, the risk of this happening is not easy to predict in clinical practice. The present cadaveric study aimed to identify morphometric measurements in a damaged vertebral body that can predict a susceptibility to accelerated creep.

methodsA total of 27 vertebral trabeculae samples cored from five cadaveric spines (3 male, 2 female, aged 36 to 73 (mean 57) years) were mechanically tested to establish the relationship between bone damage and residual strain. Compression testing of 28 human spinal motion segments (three vertebrae and intervening soft tissues) dissected from 14 cadaveric spines (10 male, 4 female, aged 67 to 92 (mean 80) years) showed how the rate of creep of a damaged vertebral body increases with increasing "damage intensity" in its trabecular bone. Damage intensity was calculated from vertebral body residual strain following initial compressive overload using the relationship established in the compression test of trabecular bone samples.

resultsCalculations from trabecular bone samples showed a strong nonlinear relationship between residual strain and trabecular bone damage intensity (R

conclusionThese findings suggest that morphometric measurements obtained from fractured vertebrae can be used to quantify vertebral damage and hence to predict progressive vertebral deformity.

Indexed as

Spinal FracturesSpineAgedAged, 80 and overCancellous BoneFemaleHumansLumbar VertebraeMaleMiddle AgedPressureStress, MechanicalClinical imagingCreepDeformityResidual strainVertebral damageVertebral morphometry

Identifiers

PMID34613493
OpenAlexW3202739786

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.