Evidence map›Paper›PMID 34613449›Full record

ArticleWorld journal of urology2022

The value of procalcitonin for predicting urosepsis after mini-percutaneous nephrolithotomy or flexible ureteroscopy based on different organisms.

Minghui Liu, Zewu Zhu, Yu Cui, Huimin Zeng, Yongchao Li, Fang Huang, Zhongxiao Cui, Feng Zeng, Zhiyong Chen, Yang Li and 3 more

Erratum issuedAbstract read
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In one paragraph

Article in World journal of urology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Minghui LiuDepartment of Urology, Xiangya Hospital, Central South University, Changsha, 410008, China.
Zewu ZhuDepartment of Urology, Xiangya Hospital, Central South University, Changsha, 410008, China.
Yu CuiDepartment of Urology, Xiangya Hospital, Central South University, Changsha, 410008, China.
Huimin ZengDepartment of Urology, Xiangya Hospital, Central South University, Changsha, 410008, China.
Yongchao LiDepartment of Urology, Xiangya Hospital, Central South University, Changsha, 410008, China.
Fang HuangDepartment of Urology, Xiangya Hospital, Central South University, Changsha, 410008, China.
Zhongxiao CuiDepartment of Urology, Xiangya Hospital, Central South University, Changsha, 410008, China.
Feng ZengDepartment of Urology, Xiangya Hospital, Central South University, Changsha, 410008, China.
Zhiyong ChenDepartment of Urology, Xiangya Hospital, Central South University, Changsha, 410008, China.
Yang LiDepartment of Urology, Xiangya Hospital, Central South University, Changsha, 410008, China.
Xiaoqiong ZhangTransplantation Center, Xiangya Hospital, Central South University, Changsha, 410008, China. zhangxiaoqiong2021@126.com.
Jinbo ChenDepartment of Urology, Xiangya Hospital, Central South University, Changsha, 410008, China. chenjinbo1989@yahoo.com.
Hequn ChenDepartment of Urology, Xiangya Hospital, Central South University, Changsha, 410008, China. chenhequnxy@126.com.ORCID http://orcid.org/0000-0002-4286-9308
Central South University · CN

Funding

National Natural Science Foundation of China 81770705Natural Science Foundation of Hunan Province 2017JJ3482
6 · The paper itself

Abstract

purposeTo assess the value of procalcitonin (PCT) as an early biomarker for predicting urosepsis caused by Gram-negative (GN) bacteria, Gram-positive (GP) bacteria and fungi following mini-percutaneous nephrolithotomy (mPCNL) and flexible ureteroscopy (FURS).

methodsA total number of 356 patients with positive preoperative UC (urine cultures) who underwent mPCNL and FURS between June 2017 and January 2021 were retrospectively analyzed. Univariable analysis and multivariable logistic regression analysis were conducted to compare the predictors for urosepsis caused by different organisms. Furthermore, the nomogram was established as a predicted model for urosepsis.

resultsAmong 356 positive UC, 265 (74.4%) were positive for GN bacteria, 77 (21.4%) for GP bacteria and 14 (3.9%) for fungal pathogens. Escherichia coli (48.9%) were the predominant pathogens and Enterococcus (54/77) were the most common GP bacteria. Multivariate logistic regression analysis showed that positive nitrite (OR 3.31, 95% CI 1.20-9.14; P = 0.021), operative time > 90 min (OR 3.10, 95% CI 1.10-8.75, P = 0.033) and postoperative PCT > 0.1 ng/mL (OR 56.18, 95% CI 15.20-207.64, P < 0.001) were associated with postoperative urosepsis originated in GN infections, while urosepsis caused by GP bacteria and fungi was not associated with PCT > 0.1 ng/mL (P = 0.198), only stone burden > 800 mm

conclusionsFor patients with positive preoperative UC, postoperative PCT > 0.1 ng/mL was an independent risk factor of post-PCNL and post-FURS urosepsis caused by GN bacteria rather than GP bacteria and fungi.

Indexed as

Kidney CalculiNephrolithotomy, PercutaneousHumansProcalcitoninRetrospective StudiesUreteroscopesUreteroscopyProcalcitoninFlexible ureteroscopyGram-negative bacteriaGram-positive bacteriaMini-percutaneous nephrolithotomyProcalcitonin

Identifiers

PMID34613449
OpenAlexW3202102057

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.