ArticleCerebral cortex (New York, N.Y. : 1991)2022
From Molecular to Behavior: Higher Order Occipital Cortex in Major Depressive Disorder.
Article in Cerebral cortex (New York, N.Y. : 1991), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Brain-wide changes in excitation-inhibition balance of major depressive disorder: a systematic review of topographic patterns of GABA- and glutamatergic alterations.Molecular psychiatry · 2023Pooled it
- Distinct Biotypes of Visual Perception in Major Depressive Disorder.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Free water, occipital volume and changes in depressive symptoms in the LifeAfter90 study.Scientific reports · 2026Article
- Task-state P300 and functional brain network abnormalities in adolescent major depressive disorder: a Stroop paradigm study.Frontiers in psychiatry · 2026Article
- Impaired connectivity between the thalamus and the visual pathway in schizophrenia: a multimodal magnetic resonance imaging study.Psychoradiology · 2026Article
- Visuomotor dysconnectivity as a candidate mechanism of psychomotor agitation in major depression.Psychological medicine · 2025Article
- Reduced neural suppression at occipital cortex in subthreshold depression.Translational psychiatry · 2025Article
- Increased individual variability in functional connectivity of the default mode network and its genetic correlates in major depressive disorder.Scientific reports · 2025Article
- BPEN: Brain Posterior Evidential Network for trustworthy brain imaging analysis.Neural networks : the official journal of the International Neural Network Society · 2025Article
- Altered Brain Functional Connectivity and Peripheral Transcriptomic Profiles in Major Depressive Disorder With Childhood Maltreatment.Depression and anxiety · 2025Article
- The Deteriorated Center-Surround Suppression in Patients With First-Episode and Drug-Naïve Major Depressive Disorder.Depression and anxiety · 2025Article
- Altered static and dynamic functional connectivity in major depressive disorder accompanied by high anxiety: evidence from the REST-meta-MDD consortium.Frontiers in psychiatry · 2025Article
- Sex differences in the human brain related to visual motion perception.Biology of sex differences · 2024Article
- GABAergic inhibition in human hMT+ predicts visuo-spatial intelligence mediated through the frontal cortex.eLife · 2024Article
- Motor versus Psychomotor? Deciphering the Neural Source of Psychomotor Retardation in Depression.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Irregularity of visual motion perception and negative symptoms in schizophrenia.Schizophrenia (Heidelberg, Germany) · 2024Article
- Is depression a global brain disorder with topographic dynamic reorganization?Translational psychiatry · 2024Review
- Differential role of fusiform gyrus coupling in depressive and anxiety symptoms during emotion perception.Social cognitive and affective neuroscience · 2024Article
- Impaired visual-motor functional connectivity in first-episode medication-naïve patients with major depressive disorder.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Abnormal activation patterns in MT+ during visual motion perception in major depressive disorder.Frontiers in psychiatry · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
Medial prefrontal cortex (MPFC) and other regions like the occipital cortex (OC) exhibit abnormal neural activity in major depressive disorder (MDD). Their relationship to specific biochemical, psychophysical, and psychopathological changes remains unclear, though. For that purpose, we focus on a particular subregion in OC, namely middle temporal (MT) visual area that is known to mediate the perception of visual motion. Using high-field 7 T magnetic resonance imaging (MRI), including resting state functional MRI and proton magnetic resonance spectroscopy, the amplitude of low-frequency fluctuations (ALFF) of the blood oxygen level-dependent signal in MT, MT-seeded functional connectivity (FC), and gamma-aminobutyric acid (GABA) in MT were investigated. Applying the vision motion psychophysical task, the motion suppression index of subjects was also examined. We demonstrate significantly elevated neural variability (as measured by ALFF) in MT together with decreases in both MT GABA and motion suppression in our MDD sample. Unlike in healthy subjects, MT neural variability no longer modulates the relationship of MT GABA and motion suppression in MDD. MT also exhibits reduction in global inter-regional FC to MPFC in MDD. Finally, elevated MT ALFF relates to specifically retardation in behavior as measured by the Hamilton subscore. Together, MT provides a strong candidate for biomarker in MDD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.