Evidence map›Paper›PMID 34612814›Full record

ArticleeLife2021

AKAP79 enables calcineurin to directly suppress protein kinase A activity.

Timothy W Church, Parul Tewatia, Saad Hannan, João Antunes, Olivia Eriksson, Trevor G Smart, Jeanette Hellgren Kotaleski, Matthew G Gold

Open access · goldAbstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Amyloid-β Causes NMDA Receptor Dysfunction and Dendritic Spine Loss through mGluR1 and AKAP150-Anchored Calcineurin Signaling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Timothy W ChurchDepartment of Neuroscience, Physiology & Pharmacology, University College London, London, United Kingdom.ORCID 0000-0002-5958-6304
Parul TewatiaScience for Life Laboratory, School of Electrical Engineering and Computer Science, KTH Royal Institute of Technology, Stockholm, Sweden.ORCID 0000-0002-3096-1318
Saad HannanDepartment of Neuroscience, Physiology & Pharmacology, University College London, London, United Kingdom.ORCID 0000-0003-4594-0808
João AntunesScience for Life Laboratory, School of Electrical Engineering and Computer Science, KTH Royal Institute of Technology, Stockholm, Sweden.ORCID 0000-0001-9635-5145
Olivia ErikssonScience for Life Laboratory, School of Electrical Engineering and Computer Science, KTH Royal Institute of Technology, Stockholm, Sweden.ORCID 0000-0003-0740-4318
Trevor G SmartDepartment of Neuroscience, Physiology & Pharmacology, University College London, London, United Kingdom.ORCID 0000-0002-9089-5375
Jeanette Hellgren KotaleskiScience for Life Laboratory, School of Electrical Engineering and Computer Science, KTH Royal Institute of Technology, Stockholm, Sweden.ORCID 0000-0002-0550-0739
Matthew G GoldDepartment of Neuroscience, Physiology & Pharmacology, University College London, London, United Kingdom.ORCID 0000-0002-1281-0815
Science for Life Laboratory · SEUniversity College London · GB

Funding

Biotechnology and Biological Sciences Research Council BB/N015274/1Medical Research Council MR/T002581/1Wellcome TrustWellcome Trust 104194/Z/14/AWellcome Trust 217199/Z/19/Z
6 · The paper itself

Abstract

Interplay between the second messengers cAMP and Ca

Indexed as

A Kinase Anchor ProteinsAnimalsCalcineurinCyclic AMP-Dependent Protein KinasesEscherichia coliHEK293 CellsHippocampusHumansLong-Term Synaptic DepressionRatsRats, Sprague-DawleySignal TransductionAKAP5 protein, humanA Kinase Anchor ProteinsCalcineurinCyclic AMP-Dependent Protein Kinasesanchoring proteinbiochemistrycalcineurincalciumchemical biologycyclic AMPneuroscienceprotein kinase Aratsynaptic plasticity

Identifiers

PMID34612814
PMCPMC8560092
OpenAlexW3201847124

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.