ArticleEnvironmental health perspectives2021
Beyond Cholinesterase Inhibition: Developmental Neurotoxicity of Organophosphate Ester Flame Retardants and Plasticizers.
Article in Environmental health perspectives, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it, 121 citations in OpenAlex.
- Systematic Review of Metallic, Industrial, and Pharmaceutical Emerging Contaminants in Snow and Ice: A Global Perspective from Polar and High-Mountain Regions.Molecules (Basel, Switzerland) · 2026Pooled it
- Firemaster 550 differentially alters gene expression underlying synaptic function in amygdala of prairie voles after gestational or lactational exposure.Neurotoxicology · 2026Article
- Prevalent detection of multiclass environmental chemicals in paired CSF and plasma samples and their potential associations with postpartum depressive symptoms in pregnant women.Environmental research · 2026Article
- Identifying associations and key early life exposure windows for organophosphate esters and adolescent brain morphometry in the HOME study.Environmental research · 2026Article
- Association between gestational and childhood exposures to organophosphate esters and social skill, problem behavior among adolescents.Environmental research · 2026Article
- An environmentally relevant mixture of organophosphate esters induces cholesterol biosynthesis in THP-1 macrophages.Toxicological sciences : an official journal of the Society of Toxicology · 2026Article
- Sex-specific disruption of estrogen receptor alpha (ERα) density in the social brain neural network by Firemaster 550.Journal of the Endocrine Society · 2026Article
- Organophosphate ester flame retardants and plasticizers in house dust and Child Behavior Checklist outcomes: A nested study in the Canadian CHILD Birth Cohort.Journal of exposure science & environmental epidemiology · 2026Article
- Evaluation of Migration, Bioaccessibility, and Dietary Risk of Organophosphate Flame Retardants in Polypropylene Packaging Using a Packaging-Food-Digestion Simulation System.Foods (Basel, Switzerland) · 2026Article
- Prenatal exposure to organophosphate ester flame retardants and child cognition: Findings from the environmental influences on child Health Outcomes cohort.Environmental pollution (Barking, Essex : 1987) · 2026Article
- Unveiling Chemical-Microbial Cascade Risk Factors from Plastic Pipe Leaching in Drinking Water.Environmental science & technology · 2025Article
- Organophosphate Flame Retardants, Obesity, and Depressive Symptoms among 1019 Young Healthy Men.Environment & health (Washington, D.C.) · 2025Article
- Prenatal Persistent Exposure to Organophosphate Esters and Early Childhood Brain Development: A Longitudinal Analysis.Environment & health (Washington, D.C.) · 2025Article
- Metabolome informs about the chemical exposome and links to brain health.Environment international · 2025Review
- Prenatal exposure to organophosphate ester flame retardants and behavioral outcomes in early childhood in the Environmental influences on Child Health Outcomes (ECHO) cohort.Environment international · 2025Article
- Oxidative Stress and Neurotoxicity Biomarkers in Fish Toxicology.Antioxidants (Basel, Switzerland) · 2025Review
- A Comprehensive, Simple, Robust, and Solvent-Free Method Covering Ultrashort- to Long-Chain PFAS in Atmospheric Samples.Analytical chemistry · 2025Article
- Epigenetic regulation in spinal muscular atrophy: emerging areas and future directions.Orphanet journal of rare diseases · 2025Review
- Associations between organophosphate flame retardants metabolites in follicular fluid and reproductive outcomes among women undergoing IVF/ICSI treatment in Southwest China.Reproductive biology and endocrinology : RB&E · 2025Article
- Association between exposure to organophosphate esters and cognitive function in older adults in the United States: NHANES 2011-2014.BMC geriatrics · 2025Article
Corrections and comments
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Authors and funding
11 authors at 6 institutions in 2 countries.
Funding
Abstract
backgroundTo date, the toxicity of organophosphate esters has primarily been studied regarding their use as pesticides and their effects on the neurotransmitter acetylcholinesterase (AChE). Currently, flame retardants and plasticizers are the two largest market segments for organophosphate esters and they are found in a wide variety of products, including electronics, building materials, vehicles, furniture, car seats, plastics, and textiles. As a result, organophosphate esters and their metabolites are routinely found in human urine, blood, placental tissue, and breast milk across the globe. It has been asserted that their neurological effects are minimal given that they do not act on AChE in precisely the same way as organophosphate ester pesticides.
objectivesThis commentary describes research on the non-AChE neurodevelopmental toxicity of organophosphate esters used as flame retardants and plasticizers (OPEs). Studies in humans, mammalian, nonmammalian, and DISCUSSION: Collectively, the findings presented demonstrate that OPEs can alter neurodevelopmental processes by interfering with noncholinergic pathways at environmentally relevant doses. Application of a pathways framework indicates several specific mechanisms of action, including perturbation of glutamate and gamma-aminobutyric acid and disruption of the endocrine system. The effects may have implications for the development of cognitive and social skills in children. Our conclusion is that concern is warranted for the developmental neurotoxicity of OPE exposure. We thus describe important considerations for reducing harm and to provide recommendations for government and industry decision makers. https://doi.org/10.1289/EHP9285.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.