Evidence map›Paper›PMID 34612661›Full record

ArticleMicrobiology spectrum2021

Akkermansia muciniphila Alleviates Dextran Sulfate Sodium (DSS)-Induced Acute Colitis by NLRP3 Activation.

Siwen Qu, Lina Fan, Yadong Qi, Chaochao Xu, Yingying Hu, Shujie Chen, Wei Liu, Weili Liu, Jianmin Si

Open access · goldAbstract read
In one paragraph

Article in Microbiology spectrum, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 133 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
133citing papers in PubMed, 3 pooled it
13.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

133 citing papers in PubMed, 3 syntheses or guidelines pooled it, 233 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Review
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  17. Review
  18. Review
  19. Article
  20. Extracellular vesicles from pasteurizedFrontiers in microbiology · 2026
    Article

73 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Siwen Qu *Department of Gastroenterology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang Universitygrid.13402.34, Hangzhou, China.
Lina Fan *Department of Gastroenterology, Second Affiliated Hospital, School of Medicine, Zhejiang Universitygrid.13402.34, Hangzhou, China.
Yadong Qi *Department of Gastroenterology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang Universitygrid.13402.34, Hangzhou, China.
Chaochao XuDepartment of Gastroenterology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang Universitygrid.13402.34, Hangzhou, China.
Yingying HuDepartment of Gastroenterology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang Universitygrid.13402.34, Hangzhou, China.
Shujie ChenDepartment of Gastroenterology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang Universitygrid.13402.34, Hangzhou, China.
Wei LiuInstitute of Plant Protection and Microbiology, Zhejiang Academy of Agricultural Sciences, Hangzhou, China.
Weili LiuDepartment of Gastroenterology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang Universitygrid.13402.34, Hangzhou, China.
Jianmin SiDepartment of Gastroenterology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang Universitygrid.13402.34, Hangzhou, China.ORCID 0000-0001-6257-2512
Sir Run Run Shaw Hospital · CNSecond Affiliated Hospital of Zhejiang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Akkermansia muciniphila has been proved to play a crucial role in the progression of colitis, but its underlying mechanism remains inconclusive. In this study, we aim to investigate the effect of

Indexed as

AkkermansiaAnimalsBacteriaCaspase 1ColitisColitis, UlcerativeColonDextran SulfateGastrointestinal MicrobiomeGoblet CellsInflammasomesInflammatory Bowel DiseasesInterleukin-1betaMacrophagesMiceMice, Inbred C57BLCaspase 1Dextran SulfateIL1B protein, humanInflammasomesInterleukin-1betaNLR Family, Pyrin Domain-Containing 3 ProteinNLRP3 protein, humanNlrp3 protein, mouseTumor Necrosis Factor-alphacolitisgut inflammationinflammasomeinflammatory bowel diseaseprobiotics

Identifiers

PMID34612661
PMCPMC8510245
OpenAlexW3203405081

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.