ArticleJournal of cellular and molecular medicine2021
A comparative analysis of deferoxamine treatment modalities for dermal radiation-induced fibrosis.
Article in Journal of cellular and molecular medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- Optimization of fat grafting to attenuate radiation damage: a narrative review.Gland surgery · 2026Review
- Deferoxamine Improves Radiation-Induced Peripheral Neuropathy.Journal of cellular and molecular medicine · 2026Article
- Combination of Hypoxia-Preconditioned ADSCs and Deferoxamine Can Speed Up the Healing of Diabetic Wounds by Promoting Angiogenesis and Regulating Macrophage Polarization.Stem cell reviews and reports · 2026Article
- Radiotherapy-Induced Skin Fibrosis: Pathophysiology, Emerging Therapeutics, and the Role of Dermatology.American journal of clinical dermatology · 2026Review
- Cell death and iron deposition in the liver in two murine models of acute radiation syndrome.PloS one · 2025Article
- Hypoxic microenvironment promotes diabetic wound healing by polarizing macrophages to the M2 phenotype in vivo.Journal of molecular histology · 2024Article
- Single-cell transcriptional analysis of irradiated skin reveals changes in fibroblast subpopulations and variability in caveolin expression.Radiation oncology (London, England) · 2024Article
- Adipose-Derived Stromal Cell-Based Therapies for Radiation-Induced Fibrosis.Advances in wound care · 2024Review
- Deferoxamine topical cream superior to patch in rescuing radiation-induced fibrosis of unwounded and wounded skin.Journal of cellular and molecular medicine · 2024Article
- A tension offloading patch mitigates dermal fibrosis induced by pro-fibrotic skin injections.Research square · 2024Article
- Radiation-induced skin reactions: oxidative damage mechanism and antioxidant protection.Frontiers in cell and developmental biology · 2024Review
- Review
- [Deferoxamine promotes recovery of bone marrow hematopoietic function in mice exposed to a sublethal dose of X-ray irradiation].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2023Article
- Chelating the valley of death: Deferoxamine's path from bench to wound clinic.Frontiers in medicine · 2023Article
- Noninvasive Systemic Modalities for Prevention of Head and Neck Radiation-Associated Soft Tissue Injury: A Narrative Review.Journal of reconstructive microsurgery · 2022Review
- Fat Grafts Augmented With Vitamin E Improve Volume Retention and Radiation-Induced Fibrosis.Aesthetic surgery journal · 2022Article
- Transdermal deferoxamine administration improves excisional wound healing in chronically irradiated murine skin.Journal of translational medicine · 2022Article
- A Composite Deferoxamine/Black Phosphorus Nanosheet/Gelatin Hydrogel Scaffold for Ischemic Tibial Bone Repair.International journal of nanomedicine · 2022Article
- A comparative analysis of deferoxamine treatment modalities for dermal radiation-induced fibrosis.Journal of cellular and molecular medicine · 2021Article
Corrections and comments
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Authors and funding
12 authors at 1 institution in 2 countries.
Funding
Abstract
The iron chelator, deferoxamine (DFO), has been shown to potentially improve dermal radiation-induced fibrosis (RIF) in mice through increased angiogenesis and reduced oxidative damage. This preclinical study evaluated the efficacy of two DFO administration modalities, transdermal delivery and direct injection, as well as temporal treatment strategies in relation to radiation therapy to address collateral soft tissue fibrosis. The dorsum of CD-1 nude mice received 30 Gy radiation, and DFO (3 mg) was administered daily via patch or injection. Treatment regimens were prophylactic, during acute recovery, post-recovery, or continuously throughout the experiment (n = 5 per condition). Measures included ROS-detection, histology, biomechanics and vascularity changes. Compared with irradiated control skin, DFO treatment decreased oxidative damage, dermal thickness and collagen content, and increased skin elasticity and vascularity. Metrics of improvement in irradiated skin were most pronounced with continuous transdermal delivery of DFO. In summary, DFO administration reduces dermal fibrosis induced by radiation. Although both treatment modalities were efficacious, the transdermal delivery showed greater effect than injection for each temporal treatment strategy. Interestingly, the continuous patch group was more similar to normal skin than to irradiated control skin by most measures, highlighting a promising approach to address detrimental collateral soft tissue injury following radiation therapy.
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Registered trials
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