Observational studyJournal of the American Geriatrics Society2021
Intraoperative hypotension and delirium among older adults undergoing transcatheter aortic valve replacement.
Observational study in Journal of the American Geriatrics Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
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Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- The effect of intraoperative hypotension on postoperative delirium: a meta-analysis and systematic review.Frontiers in medicine · 2025Pooled it
- Association of general anesthesia exposure with risk of postoperative delirium in patients receiving transcatheter aortic valve replacement: a meta-analysis and systematic review.Scientific reports · 2023Pooled it
- Association between intraoperative hypotension and postoperative ICU delirium: a retrospective observational study.Journal of anesthesia · 2026Observational
- Predictors and Prognostic Impact of Perioperative Hypotension During Transcatheter Aortic Valve Implantation: The Role of Diabetes Mellitus and Left Ventricular Dysfunction.Journal of cardiovascular development and disease · 2025Article
- Association between periprocedural cerebral desaturation during transcatheter aortic valve implantation and postprocedural delirium: a prospective observational study.BMC anesthesiology · 2025Observational
- Perioperative blood pressure variability as a risk factor for postoperative delirium in the patients receiving cardiac surgery.BMC anesthesiology · 2024Article
- Aortic Stenosis Management in Patients With Acute Hip Fracture.JACC. Advances · 2024Review
- The genetic relationship between hypotension and delirium: a Mendelian randomization study.Frontiers in neurology · 2024Article
- Association between intraoperative mean arterial pressure variability and postoperative delirium after hip fracture surgery: a retrospective cohort study.BMC geriatrics · 2023Article
- Effects of inflammation and oxidative stress on postoperative delirium in cardiac surgery.Frontiers in cardiovascular medicine · 2022Review
- Intraoperative hypotension and delirium among older adults undergoing transcatheter aortic valve replacement.Journal of the American Geriatrics Society · 2021Observational
Corrections and comments
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Authors and funding
13 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPostoperative delirium (POD) is a frequently observed complication after transcatheter aortic valve replacement (TAVR). The effects of intraoperative hypotension (IOH) on POD occurrence are currently unclear.
methodsA retrospective observational cohort study of patients who underwent TAVR was conducted. We predefined IOH as area under the threshold (AUT) of five mean arterial blood pressures (MBP), varying from <100 to <60 mmHg. The AUT consisted of the combination of duration and depth under the MBP thresholds, expressed in mmHg*min. All MBP AUTs were computed based on the complete procedure, independent of procedural phase or duration.
resultsThis cohort included 675 patients who underwent TAVR under general anesthesia (n = 128, 19%) or procedural sedation (n = 547, 81%). Delirium occurred mostly during the first 2 days after TAVR, and was observed in n = 93 (14%) cases. Furthermore, 674, 672, 663, 630, and 518 patients had at least 1 min intraoperative MBP <100, <90, <80, <70, and <60 mmHg, respectively. Patients who developed POD had higher AUT based on all five MBP thresholds during TAVR. The penalized adjusted odds ratio varied between 1.08 (99% confidence interval [CI] 0.74-1.56) for the AUT based on MBP < 100 mmHg and OR 1.06 (99% CI 0.88-1.28) for the AUT based on MBP < 60 mmHg.
conclusionsIntraoperative hypotension is frequently observed during TAVR, but not independently associated with POD after TAVR. Other potential factors than intraoperative hypotension may explain the occurrence of delirium after TAVR.
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