ArticleJournal of theoretical biology1986
The classification of amino acid conservation.
Article in Journal of theoretical biology, 1986. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 157 papers.
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157 citing papers in PubMed.
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- Protein language models meet reduced amino acid alphabets.Bioinformatics (Oxford, England) · 2024Article
- Intrinsically Disordered Compositional Bias in Proteins: Sequence Traits, Region Clustering, and Generation of Hypothetical Functional Associations.Bioinformatics and biology insights · 2024Article
- The T2T-CHM13 reference assembly uncovers essential WASH1 and GPRIN2 paralogues.Bioinformatics advances · 2024Article
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- Split-Ring Resonator Based Sensor for the Detection of Amino Acids in Liquids.Sensors (Basel, Switzerland) · 2023Article
- Bioinformatics characterization of BcsA-like orphan proteins suggest they form a novel family of pseudomonad cyclic-β-glucan synthases.PloS one · 2023Article
- Structure of Human Enterovirus 70 and Its Inhibition by Capsid-Binding Compounds.Journal of virology · 2022Article
97 more citing papers are in PubMed but not listed here.
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No grant is acknowledged in the PubMed record.
Abstract
A classification of amino acid type is described which is based on a synthesis of physico-chemical and mutation data. This is organised in the form of a Venn diagram from which sub-sets are derived that include groups of amino acids likely to be conserved for similar structural reasons. These sets are used to describe conservation in aligned sequences by allocating to each position the smallest set that contains all the residue types brought together by alignment. This minimal set assignment provides a simple way of reducing the information contained in a sequence alignment to a form which can be analysed by computer yet remains readable.
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