Evidence map›Paper›PMID 34612205›Full record

ArticleeLife2021

Divergent acyl carrier protein decouples mitochondrial Fe-S cluster biogenesis from fatty acid synthesis in malaria parasites.

Seyi Falekun, Jaime Sepulveda, Yasaman Jami-Alahmadi, Hahnbeom Park, James A Wohlschlegel, Paul A Sigala

Open access · goldAbstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Chemical propulsion of hemozoin crystal motion in malaria parasites.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. Article
  6. Biogenesis of CytochromesACS infectious diseases · 2025
    Article
  7. Article
  8. Identification of a divalent metal transporter required for cellular iron metabolism in malaria parasites.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  9. Biogenesis of cytochromesbioRxiv : the preprint server for biology · 2024
    Article
  10. Article
  11. Article
  12. International journal of molecular sciences · 2024
    Article
  13. Article
  14. Article
  15. Direct tests of cytochromeProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Seyi FalekunDepartment of Biochemistry, University of Utah School of Medicine, Salt Lake City, United States.ORCID 0000-0003-2280-4424
Jaime SepulvedaDepartment of Biochemistry, University of Utah School of Medicine, Salt Lake City, United States.ORCID 0000-0002-3557-4093
Yasaman Jami-AlahmadiDepartment of Biological Chemistry, University of California, Los Angeles, Los Angeles, United States.
Hahnbeom ParkDepartment of Biochemistry, University of Washington, Seattle, United States.
James A WohlschlegelDepartment of Biological Chemistry, University of California, Los Angeles, Los Angeles, United States.
Paul A SigalaDepartment of Biochemistry, University of Utah School of Medicine, Salt Lake City, United States.ORCID 0000-0002-3464-3042
University of Utah · USUniversity of California, Los Angeles · USUniversity of Washington · US

Funding

Proteomics CoreU54DK110858 · NIDDK · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Anna E Beaudin, JAMES Eric COX · 2016 to 2026
$8.6M
Proteolytic Control of Iron Metabolism by the Ubiquitin Ligase FBXL5R01GM089778 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WOHLSCHLEGEL, JAMES AKIRA · 2010 to 2023
$4.0M
Comparative Heme Metabolism in Divergent EukaryotesR35GM133764 · NIGMS · UNIVERSITY OF UTAH · PI SIGALA, PAUL A · 2019 to 2023
$2.1M
Program for Interdisciplinary Training in CHemical BiologyT32GM122740 · NIGMS · UNIVERSITY OF UTAH · PI KAY, MICHAEL S · 2018 to 2022
$932k
Q-ToF Mass Spectrometer for the University of Utah MS and Proteomics CoreS10OD018210 · OD · UNIVERSITY OF UTAH · PI COX, JAMES ERIC · 2015 to 2015
$530k
NIDDK NIH HHS U54 DK110858NIGMS NIH HHS R01 GM089778NIGMS NIH HHS R35 GM133764NIGMS NIH HHS T32 GM122740NIH HHS S10 OD018210
6 · The paper itself

Abstract

Most eukaryotic cells retain a mitochondrial fatty acid synthesis (FASII) pathway whose acyl carrier protein (mACP) and 4-phosphopantetheine (Ppant) prosthetic group provide a soluble scaffold for acyl chain synthesis and biochemically couple FASII activity to mitochondrial electron transport chain (ETC) assembly and Fe-S cluster biogenesis. In contrast, the mitochondrion of

Indexed as

Acyl Carrier ProteinFatty AcidsIronOrganelle BiogenesisPlasmodium falciparumProtozoan ProteinsSulfurAcyl Carrier ProteinFatty AcidsIronProtozoan ProteinsSulfuracyl carrier proteinbiochemistrychemical biologyFe-S cluster synthesisinfectious diseasemalariamicrobiologymitochondriaorganelle adaptationP. falciparum

Identifiers

PMID34612205
PMCPMC8547962
OpenAlexW3202048361

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.