ArticleeLife2021
Closed-loop auditory stimulation method to modulate sleep slow waves and motor learning performance in rats.
Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 38 citations in OpenAlex.
- Exposure to broadband noise during non-REM sleep impairs hippocampal sharp-wave ripples and memory consolidation.Current biology : CB · 2026Article
- Auditory Stimulation of Slow-Wave Sleep Promotes Recovery after Brain Injury in an Animal Model.Annals of neurology · 2026Article
- Auditory-evoked changes in slow oscillations and spindles correlate with memory consolidation in children with epilepsy and controls.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2026Article
- Rocking-induced sleep enhancement promotes motor learning through transcriptional and synaptic remodelling.Communications biology · 2026Article
- Differences in sleep spindles and polysomnography in humans: a meta-analysis on the influence of age, sex, and cognitive ability.Frontiers in sleep · 2026Review
- VTA dopaminergic neuronal activity during NREM sleep is modulated by learning and facilitates motor memory consolidation.Science advances · 2025Article
- Novel murine closed-loop auditory stimulation paradigm elicits macrostructural sleep benefits in neurodegeneration.Journal of sleep research · 2025Article
- Rocking during sleep reduces motor deficits and beta-amyloid levels in an Alzheimer's mouse model.iScience · 2025Article
- A Miniature Wireless Device for Closed-Loop Auditory Sleep Modulation.International IEEE/EMBS Conference on Neural Engineering : [proceedings]. International IEEE EMBS Conference on Neural Engineering · 2025Article
- Multi-region processing during sleep for memory and cognition.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2025Review
- Acoustically evoked K-complexes together with sleep spindles boost verbal declarative memory consolidation in healthy adults.Scientific reports · 2024Article
- Selective REM sleep restriction in mice using a device designed for tunable somatosensory stimulation.Journal of neuroscience methods · 2024Article
- Single closed-loop acoustic stimulation targeting memory consolidation suppressed hippocampal ripple and thalamo-cortical spindle activity in mice.The European journal of neuroscience · 2024Article
- Pharmacological enhancement of slow-wave activity at an early disease stage improves cognition and reduces amyloid pathology in a mouse model of Alzheimer's disease.Frontiers in aging neuroscience · 2024Article
- Possible mechanisms to improve sleep spindles via closed loop stimulation during slow wave sleep: A computational study.PloS one · 2024Article
- Somatostatin neuron contributions to cortical slow wave dysfunction in adult mice exposed to developmental ethanol.Frontiers in neuroscience · 2023Article
- Neuronal-spiking-based closed-loop stimulation during cortical ON- and OFF-states in freely moving mice.Journal of sleep research · 2022Article
- Down-phase auditory stimulation is not able to counteract pharmacologically or physiologically increased sleep depth in traumatic brain injury rats.Journal of sleep research · 2022Article
- Closed-loop auditory stimulation method to modulate sleep slow waves and motor learning performance in rats.eLife · 2021Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Slow waves and cognitive output have been modulated in humans by phase-targeted auditory stimulation. However, to advance its technical development and further our understanding, implementation of the method in animal models is indispensable. Here, we report the successful employment of slow waves' phase-targeted closed-loop auditory stimulation (CLAS) in rats. To validate this new tool both conceptually and functionally, we tested the effects of up- and down-phase CLAS on proportions and spectral characteristics of sleep, and on learning performance in the single-pellet reaching task, respectively. Without affecting 24 hr sleep-wake behavior, CLAS specifically altered delta (slow waves) and sigma (sleep spindles) power persistently over chronic periods of stimulation. While up-phase CLAS does not elicit a significant change in behavioral performance, down-phase CLAS exerted a detrimental effect on overall engagement and success rate in the behavioral test. Overall CLAS-dependent spectral changes were positively correlated with learning performance. Altogether, our results provide proof-of-principle evidence that phase-targeted CLAS of slow waves in rodents is efficient, safe, and stable over chronic experimental periods, enabling the use of this high-specificity tool for basic and preclinical translational sleep research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.