Evidence map›Paper›PMID 34612164›Full record

ArticleTissue barriers2022

Role of mononuclear stem cells and decellularized amniotic membrane in the treatment of skin wounds in rats.

Aline L Takejima, Julio C Francisco, Rossana B Simeoni, Lúcia de Noronha, Luiz A F M Garbers, Kátia M Foltz, Paulo A B Machado Junior, Isio C Souza, Ricardo A Pinho, Katherine A T Carvalho and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Tissue barriers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Aline L TakejimaExperimental Laboratory, The Institute of Biological and Health Sciences of the Pontifical Catholic University of Paraná (PUCPR), Curitiba, PR, Brazil.ORCID 0000-0002-2608-0171
Julio C Francisco
Rossana B SimeoniExperimental Laboratory, The Institute of Biological and Health Sciences of the Pontifical Catholic University of Paraná (PUCPR), Curitiba, PR, Brazil.
Lúcia de NoronhaPathology Department, The Institute of Biological and Health Sciences of the Pontifical Catholic University of Paraná (PUCPR), Curitiba, PR, Brazil.
Luiz A F M Garbers
Kátia M FoltzExperimental Laboratory, The Institute of Biological and Health Sciences of the Pontifical Catholic University of Paraná (PUCPR), Curitiba, PR, Brazil.
Paulo A B Machado JuniorExperimental Laboratory, The Institute of Biological and Health Sciences of the Pontifical Catholic University of Paraná (PUCPR), Curitiba, PR, Brazil.
Isio C SouzaExperimental Laboratory, The Institute of Biological and Health Sciences of the Pontifical Catholic University of Paraná (PUCPR), Curitiba, PR, Brazil.
Ricardo A PinhoLaboratory of Exercise Biochemistry in Health (BioEx) of the Pontifical Catholic University of Paraná (PUCPR), Curitiba, PR, Brazil.
Katherine A T CarvalhoAdvanced Therapy and Cellular Biotechnology in Regenerative Medicine Department, Pelé Pequeno Príncipe Institute, Curitiba, PR, Brazil.ORCID 0000-0003-4860-2855
Luiz C Guarita-SouzaExperimental Laboratory, The Institute of Biological and Health Sciences of the Pontifical Catholic University of Paraná (PUCPR), Curitiba, PR, Brazil.ORCID 0000-0003-2781-9705
Pontifícia Universidade Católica do Paraná · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stem cells (SC) and amniotic membrane (AM) are recognized for their beneficial impacts on the healing of cutaneous wounds. Thus, this study evaluated the capacity of tissue repair in a skin lesion rat model. Forty Wistar rats were randomized into four groups: group I - control, with full-thickness lesions on the back, without SC or AM; group II-injected SC; group III - covered by AM; group IV-injected SC and covered by AM. Lesion closure was assessed using contraction rate (Cr). Histochemical and immunohistochemical analyses were performed, and collagen, elastic fibers, fibroblast differentiation factor (TGF-β), collagen remodeling (MMP-8), and the number of myofibroblasts and blood vessels (α-SMA) were evaluated. On the 7

Indexed as

AmnionMatrix Metalloproteinase 8AnimalsCollagenRatsRats, WistarStem CellsTransforming Growth Factor betaCollagenMatrix Metalloproteinase 8Transforming Growth Factor betaAmniotic membraneexperimental animal modelsinflammationstem cellswound healing

Identifiers

PMID34612164
PMCPMC9067462
OpenAlexW3204751730

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.